Li-Ling Chang

National Tsing Hua University, Hsin-chu-hsien, Taiwan, Taiwan

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Publications (4)27.01 Total impact

  • Wei-Chia Huang · Nien-Chu Lai · Li-Ling Chang · Chia-Min Yang
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    ABSTRACT: Mercaptopropyl-functionalized mesoporous silica nanoparticles with c2mm symmetry and short-pitch helical channels were prepared by the cocondensation synthesis in the dilute solution of cetyltrimethylammonium bromide and tetraethylene glycol dodecyl ether (C12EO4) under alkaline conditions. The amount and distribution of the covalently coupled organic groups within the nanoparticles were investigated. Interestingly, the mesostructure transformed toward p6mm phase when the amount of mercaptopropyltrimethoxysilane was increased, and a reverse p6mm-to-c2mm transformation took place as the mole percentage of C12EO4 was further increased. The presence of C12EO4 was also found crucial for helical arrangement of the channels. In situ small-angle X-ray scattering measurements showed that the addition of the functional silane slightly accelerated both the growth and structural deformation of the materials. The results were discussed based on the kinetics of the cooperative assembly of silicate species and the micelles of mixed surfactants and the interplay between the hydrolyzed silanes and surfactant molecules.
    Microporous and Mesoporous Materials 03/2012; 151:411–417. DOI:10.1016/j.micromeso.2011.09.033 · 3.45 Impact Factor
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    ABSTRACT: We report here the synthesis of mesoporous silicananostructures simultaneously having helical morphology and c2mm symmetry correlated to a ribbon intermediate phase. A mixture of four types of helical nanostructures, including short-pitch (just a few lattice constants) sphere-like nanoparticles, short-pitch straight nanorods, long-pitch (hundreds of nanometres) twisted nanorods and long-pitch spiral nanorods could be produced. A formation mechanism was proposed based on the in situ small-angle X-ray scattering (SAXS) measurements and other analyses, with the emphasis on the influences of the assembly kinetics on the structural and morphological properties of the helical nanostructures. Based on the mechanism, we further showed simple kinetic control to prepare solely short-pitch or long-pitch helical nanostructures. The present study demonstrates the possibility to tailor the helical mesostructures through kinetic control and offers prospects for the design and preparation of these types of materials.
    RSC Advances 08/2011; 1(2):229-237. DOI:10.1039/C1RA00013F · 3.84 Impact Factor
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    ABSTRACT: A main challenge in nanobiomedicine is the engineering of nanostructures or nanomaterials that can efficiently encapsulate drugs at high load, cross cell membranes, and controllably release their cargo at target sites. Although mesoporous silica nanoparticles (MSNs) are safe, versatile, and promising carrier materials for targeted drug delivery, their aggregation phenomena under physiological conditions (or salt-containing environments) and their nonspecific binding in protein-containing solutions (or serum) limit their applications in biological science and biomedicine. To address this challenge, we have developed a novel delivery system, termed a nanoshuttle, comprising a nanoscale PEGylated-phospholipid coating and 13-(chlorodimethylsilylmethyl)heptacosane-derivatized MSNs, in which therapeutic or imaging agents may be trapped and ligand-assisted targeted delivery may be achieved through surface functionalization of the phospholipids. As a proof of concept in this study, we selected fluorescein isothiocyanate and folate as the imaging tracer and targeted ligand, respectively. Relative to the bare MSNs, the lipid-capped MSNs exhibited superior suspensibility in phosphate-buffered saline and much lower nonspecific binding in vitro. Furthermore, enhanced specific cellular uptake by Hela cells occurred after administering the folate-sensitized phospholipid-capped MSNs. Our results suggest that these highly versatile multifunctional MSNs are promising vectors for nanomedicine applications.
    ACS Nano 08/2010; 4(8):4371-9. DOI:10.1021/nn901376h · 12.88 Impact Factor
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    ABSTRACT: Mesoporous silica nanoparticles with a two-dimensional center-rectangular (plane group c2mm) lattice and coiled elliptical channels have been synthesized; the new synthetic route also allows simple control over the lattice dimensions and the elliptical shape of the channels.
    Chemical Communications 01/2009; DOI:10.1039/b812967c · 6.83 Impact Factor