Nazim Uddin Ahmed

Bangladesh Council of Scientific & Industrial Research, Chittagong Ghat, Chittagong, Bangladesh

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Publications (18)3.03 Total impact

  • Biological research 08/2014; 47:36. · 1.13 Impact Factor
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    ABSTRACT: The present study was undertaken to evaluate the antidiabetic properties with phytochemical screening of the ethanol leaves extracts of two common indigenous medicinal plants of Bangladesh -Azadirachta indica (Neem) and Andrographis peniculata (Kalomegh) on experimental animal model. Hypoglycemic activity of the concentrated ethanolic (90%) extract of Azadirachta indica and Andrographis peniculata were studied compared with that of a reference antidiabetic drug glimeperide in both glucose loaded and alloxan induced diabetic rats. The acute toxicity of these two plants extract was also studied. Experimental results showed that ethanol leaves extract (1 gm/kg) of Azadirachta indica and Andrographis peniculata significantly (P<0.01) reduced the elevated blood glucose level by 36.91 % and 40.65 % respectively in glucose loaded rats and 30.20 % and 32.18 % respectively in alloxan induced diabetic rats compared to the respective diabetic control group. This study strongly suggested that ethanol leaves extracts of Azadirachta indica and Andrographis peniculata possess significant antidiabetic activity and could be a potential source for treatment of diabetes mellitus.
    01/2013; 5(2):2278-3008.
  • Rahman MA, Azad AK, Ahmed NU, Islam MS
    AFRICAN JOURNAL OF BIOTECHNOLOGY 01/2013; 12(2):212-218. · 0.57 Impact Factor
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    ABSTRACT: The present study was carried out to investigate the antidiabetic and antioxidant effect with phytochemical screening of ethanol extract of Saurauia roxburghii. The ethanol extract of Saurauia roxburghii was evaluated for its antidiabetic activities in alloxan induced diabetic rats. The significant reduction in blood glucose levels of the ethanol extract at 2g/kg dose exhibited a peak effect of 53.51% using glucometer. It gives the lowering blood glucose effects. The DPPH free radical scavenging effect of the ethanol extract was compared with standard antioxidant ascorbic acid. IC 50 values were found 37.844 µg/ml for the extract and 0.661 µg/ml for ascorbic acid. The ethanol extract was screened phytochemically for its chemical components. This revealed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, terpenes and steroids in moderate concentration. This study shows a possible beneficial effect of Saurauia roxburghii in the management of non-insulin dependent diabetes (NIDDM) and antioxidant activity. INTRODUCTION World Health Organisation (WHO) has defined medicinal plants as plants that contain properties or compounds that can be used for therapeutic purposes or those that synthesize metabolites to produce useful drugs [1] . The alkaloidal fractions of the leaf have been reported to possess weak activity against Kelebsiella pneumonia, Pseudomonas aeruginosa, Bacillis megaterium, Bacillus subtitis, Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Aspergillus niger, Microsporum species and Penicillium species [2] . The alkaloidal fraction of the stem has also been reported to be active against all micro-organisms mention above [2] . The history of diabetes is millennium old. It writings from the earliest civilizations (Asia Minor, China, Egypt, and India) refer to boils and infections, excessive thirst, loss of weight and the passing of large quantities of honey sweet urine which often drew ants
    10/2012;
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    ABSTRACT: To investigate the antilithiatic effect of the whole Leea macrophylla (L. macrophylla) Roxb (Leeaceae) ethanol extract in ethylene glycol-induced urolithiasis model of rats. Forty two seven weeks old male wistar albino rats were randomly divided into two major groups namely: preventive (n=18) and therapeutic (n=24). Preventive group was further subdivided into 3 groups of 6 rats namely: preventive control (PC), preventive lithiatic control (PLC) and preventive lithiatic L. macrophylla (PLLM). Similarly, therapeutic group was also subdivided into 4 groups of 6 rats namely: therapeutic control (TC), therapeutic lithiatic control (TLC), therapeutic lithitatic L. macrophylla (TLLM) and therapeutic lithiatic cystone (TLCYS). The lithiasis was induced by 0.75% (v/v) ethylene glycol in the drinking water of all groups except the PC and TC groups. The urinary ionic parameters such as calcium, inorganic phosphate, oxalate, magnesium & creatinine and renal morphology were altered by ethylene glycol, which were partially recovered by 14 d preventive and almost fully recovered by 28 d therapeutic intervention trials with L. macrophylla extract (500 mg/kg BW daily). Significant difference on recovery was observed between preventive and therapeutic interventional trials. Anti-urolithiatic effect of cystone was significantly (P<0.001) higher than extracts. L. macrophylla extract was found nontoxic in the acute toxicity test. The results of this study demonstrated very promising anti-urolithiatic effect of L. macrophylla extract with preventive and therapeutic treatments in this experimental condition.
    Asian Pacific Journal of Tropical Medicine 07/2012; 5(7):533-8. · 0.50 Impact Factor
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    Bangladesh Journal of Scientific and Industrial Research 01/2012; 47(1):133-136.
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    Research Journal of Medicinal Plant 01/2012; .:236-244.
  • Md. Atiar Rahman, Md. Mizanur Rahman, Nazim uddin Ahmed
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    ABSTRACT: Essential oil of Alpinia calcarata Rosc. rhizome was studied for anti-inflammatory and anti-nociceptive effects in animal models. Anti-inflammatory effect was investigated in carrageenan-induced paw edema model in Albino rat with the doses of 100, 200 and 400 mg/kg BW. Anti-nociceptive effect was measured in acetic acid-induced pain, formalin-induced pain and thermal pain (hot plate test) models in Albino mice with the doses of 200, 400 and 600 mg/kg BW. Significant (pth min of treatment in hot plate model. Results evidenced that essential oil from Alpinia calcarata could be processed to use as an alternative source of inflammatory and nociceptive treatment.
    Journal of Biologically Active Products from Nature. 01/2012; 2(6).
  • African journal of pharmacy and pharmacology 01/2012; 6(20):1469-1476. · 0.84 Impact Factor
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    ABSTRACT: The present study was carried out to investigate the antidiabetic and antioxidant effect with phytochemical screening of ethanol extract of Saurauia roxburghii. The ethanol extract of Saurauia roxburghii was evaluated for its antidiabetic activities in alloxan induced diabetic rats. The significant reduction in blood glucose levels of the ethanol extract at 2g/kg dose exhibited a peak effect of 53.51% using glucometer. It gives the lowering blood glucose effects. The DPPH free radical scavenging effect of the ethanol extract was compared with standard antioxidant ascorbic acid. IC 50 values were found 37.844 µg/ml for the extract and 0.661 µg/ml for ascorbic acid. The ethanol extract was screened phytochemically for its chemical components. This revealed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, terpenes and steroids in moderate concentration. This study shows a possible beneficial effect of Saurauia roxburghii in the management of non-insulin dependent diabetes (NIDDM) and antioxidant activity. INTRODUCTION World Health Organisation (WHO) has defined medicinal plants as plants that contain properties or compounds that can be used for therapeutic purposes or those that synthesize metabolites to produce useful drugs [1] . The alkaloidal fractions of the leaf have been reported to possess weak activity against Kelebsiella pneumonia, Pseudomonas aeruginosa, Bacillis megaterium, Bacillus subtitis, Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Aspergillus niger, Microsporum species and Penicillium species [2] . The alkaloidal fraction of the stem has also been reported to be active against all micro-organisms mention above [2] . The history of diabetes is millennium old. It writings from the earliest civilizations (Asia Minor, China, Egypt, and India) refer to boils and infections, excessive thirst, loss of weight and the passing of large quantities of honey sweet urine which often drew ants
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    ABSTRACT: Clausena suffruticosa (Family: Rutaceae) root ethanolic extract was subjected to analyze for its antioxidant effect by DPPH free radical scavenging method, antibacterial & antifungal effect by disc diffusion technique and cytotoxic effect by brine shrimp lethality test. The extract showed very significant antioxidant activity with the LC 50 value of 3.28µg/ml. In antibacterial screening, moderate zone of inhibition (7.5-9.0mm in diameter) was observed against gram positive Bacillus subtilis, Bacillus cereus, Streptococcus aureus, Bacillus polymyxa & Bacillus megaterium and promising zone of inhibition (10.0-13.0mm in diameter) against gram negative Salmonella typhi, Shigella flexneri,, Proteus sp. & Escherichia coli. Klebsiella sp. and Shigella sonnei did not show sensitivity. The MIC values against these bacteria were ranged from 3,000 to 4,500µg/ml. Root extract showed significant zone of inhibition against Aspergillus ustus, Aspergillus niger and Aspergillus ochraceus in antifungal assay. In the cytotoxicity assay, LD 50 and Chi-square value of the ethanolic extract against brine shrimp nauplii were 546.94µg/ml and 1.9932 demonstrating potent cytotoxic effect of the extract.
    Journal of Applied Pharmaceutical Science. 01/2011; 01(2011):90-95.
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    ABSTRACT: The hypocholesterolemic effects of the ethanol extract of Ananas comosas (L.) Merr. (Pineapple) was investigated in 5 groups of albino rats, 7 in each group. Group I rat received only distilled water and served as normal control. Groups II, III, IV and V were made hypercholesterolemic by feeding cholesterol orally suspended in 2% cholic acid mixed soybean oil (1 ml/kg bw) at a dose of 100 mg/kg bw daily up to 60 days. Group II rat received 1 ml distilled water while animals of Group III, IV and V received ethanol extract of Ananas comosas (L.) Merr. at the dose of 1000 mg/kg, 500 mg/kg and 100 mg/kg body weight respectively daily up to 60 days in addition to cholesterol as above. At the end of 60th day animals were sacrificed and blood samples were collected for measurement of lipid profiles using enzymatic kit. Administration of cholesterol caused a significant rise (p<0.001) in the serum levels of total cholesterol, LDL-cholesterol and triglycerides. Simultaneous administration of three different doses of Ananas comosas (L.) Merr. extract namely 1000 mg/kg, 500 mg/kg and 100 mg/kg for 60 days decreased serum cholesterol level by 62%, 47%, and 42% respectively (p<0.001); serum triglycerides level by 62.7%, 58.7%, and 49.09% respectively (p<0.001); serum LDL level by 70.5%, 53.9% and 51.15%, respectively (p<0.01). However, serum HDL level was not affected significantly. The cumulative results clearly indicate ethanol extract of Ananas comosas (L.) Merr. leaves possesses potent hypocholesterolaemic effect.
    International Journal of Life Sciences. 01/2011; 5(1).
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    ABSTRACT: The present study was carried out to investigate the antinociceptive and anti-inflammatory properties of methanol leaf extract of Argyreia argentea. Antinociceptive properties of the extract were evaluated on the pain induced by acetic acid and formalin in Swiss albino mice. The extract at a dose of 1, 1.5 and 2 gkg-1 produced an inhibition of15.81%, 52.91% and 58.71% on acetic acid induced pain and an inhibition of 29.56%, 39.51% and 45.96% on formalin induced pain. Oral administration of the extract significantly (P<0.001 and P<0.01) reduced writhing response induced by acetic acid and licking response induced by formalin. The anti-inflammatory activity of thesame extract was estimated by measuring the mean increase in hind paw volume of carrageenan-induced Wistar albino rat with the help of plethysmometer. Oral administration of extract at a dose of 0.5, 1.0 and 1.5 gkg-1 showed the highest inhibition 25.92%, 37.03%, and 34.57%, respectively at the 4th hour of administration. Argyreiaargentea extract showed significant (P<0.001 and P<0.01) effect in the reduction of the paw edema induced by carrageenan. The degree of anti-inflammatory and antinociceptive activity of extract was compared to the effect of standard drug diclofenac sodium. Morphine is used as a standard drug in formalin induced licking response model. In acute toxicity study, no mortality was observed at 4 gkg-1 dose level. The present study demonstrates the potential anti-inflammatory and analgesic effect of the methanol leaf extract of Argyreia argentea which supports the claims by the traditional medicine practitioners.
    Journal of Pharmaceutical Sciences and Research. 01/2010;
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    ABSTRACT: The bark of Adenanthera pavonina L. was extracted in pet-ether (PE), dichloromethane (DCM), ethyl acetate (EA) and methanol (ME) successively and evaluated the analgesic, antimicrobial, antioxidant activity of the extracts. The phytochemical screening of the extracts was carried out using standard method of analysis. This investigation revealed saponins, alkaloids, carbohydrate, cardiac glycosides, tannins, flavanoids and steroids are rich in ME and EA extracts. In the analgesic activity by acetic acid-induced writhing test in mice, the extracts were given interperitonially at a dose of 100 and 200 mg/kg in different groups of mice. The results showed that DCM extract (200 mg/kg) showed the highest (72.081%) analgesic activity while PE extracts (100mg/kg) showed the lowest (23.35%) activity in comparison to those of indomethacin (8 mg/kg) and diclofenac sodium (15 mg/kg) as reference drugs. The highest antimicrobial potential was observed in crude ME extracts against gram-positive, gram-negative bacteria and fungi at dosage levels of 100, 200, and 400 μg/disc. Their zones of inhibition were compared with the standard antibiotic Kanamycin (30 μg/disc). The extracts exhibited significant free radical scavenging activity when compared with ascorbic acid (ASA) and tert-butyl-1-hydroxytoluene (BHT). The IC50 value for antioxidant activity of PE, DCM, EA and ME extracts were found to be 390.33±2.78, 32.13±0.38, 8.72±0.11 and 6.44±0.04μg/ml respectively. The results suggest that the extract could be used in the treatment of pain disorder, as anti-microbial as well as anti-oxidant.
    Advances in Natural and Applied Sciences 01/2010; 4(3):352-360.
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    Bangladesh Journal of Scientific and Industrial Research 01/2009; 44(2).
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    ABSTRACT: The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These results revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.
    Bangladesh Journal of Pharmacology. 01/2009;
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    ABSTRACT: This study was subjected to investigate antioxidant, cytotoxic and antimicrobial (antibacterial and antifungal) properties of Eclipta alba ethanol extract. The antioxidant and cytotoxic properties of the extract were assessed by DPPH free radical scavenging method and brine shrimp lethality bioassay, respectively. Disc diffusion technique and food poisoning technique were used to determine the antibacterial and antifungal activity of the extract, respectively. DPPH free radical scavenging effect of extract was compared with standard antioxidant ascorbic acid. IC50 value was found 1.34μg/ml for extract and 1.03μg/ml for ascorbic acid. LC50 value of the extract in brine shrimp lethality bioassay was found 94.3μg/ml. Large zone of inhibition were observed in disc diffusion antibacterial screening against gram negative Salmonella typhi, Shigella sonnei, Escherichia coli, Salmonella paratyphi, Pseudomonas sp (1) & Pseudomonas sp (II), and gram positive Bacillus subtilis, Bacillus cereus, Bacillus megaterim & Staphylococcus aureus at the concentration of 1mg/disc. The extract concentration 250μg/disc showed no zone of inhibition to any bacterial strain but 500μg/disc showed a moderate zone of inhibition (8mm) against Salmonella typhi. In antifungal assay, the maximum 51.52% of anti-mycotic activity was observed against Aspergillus ochraceus. Fluconazole was used as standard antifungal agent. Extract was found nontoxic in acute toxicity test in mice.
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    ABSTRACT: The present study was carried out to investigate anti-inflammatory, antioxidant and anti-diarrheal effect of ethanol extract of Stephania japonica. This study showed that the plant extract has significant (p<0.05) anti-inflammatory effect at all phases of carrageenan induced inflammation at a dose level 2g/kg. The DPPH free radical scavenging effect of the extract was compared with standard antioxidant ascor-bic acid. IC 50 values were found 33.57 µg/ml for the extract and 15.57 µg/ml for ascorbic acid. S. japonica extract at dosage level 2g/kg and 1g/kg decreased the gastrointestinal motility 36.56 and 21.53 %, respectively, in rats. The ethanol extract of the plant also reduced the total number of feces as well as wet feces of rats in castor oil-induced diarrheal model. The results revealed that the extract possesses prom-ising anti-inflammatory, antioxidant and antidiarrheal activity.