[show abstract][hide abstract] ABSTRACT: The aim of this study was to assess the relationship between serum and saliva levels of cancer antigen (CA) 15-3 and to compare them between women with and without breast cancer.
A case-control study was carried out on 61 women aged 28-69 years, including women with and without breast cancer (26 as part of the case study and 35 as part of the control group) conducted at the Emam Khomeini Hospital, Tehran University of Medical Sciences. CA 15-3 levels were assayed in serum and unstimulated whole saliva by EIA. Unpaired t-test, one-way ANOVA and Pearson correlation were used as statistical analysis.
The salivary and serological levels of CA 15-3 in the cancer patients were significantly higher (P <0.01) than the salivary and serum levels of healthy controls. They were also higher in stage 2 than in stage 1 in cancer patients. However, the saliva flow rate was significantly lower in the cancer patients (P <0.01). There was a significant positive correlation between serum and saliva CA 15-3 concentration (r = 0.614) and also between serum concentration and saliva output of CA 15-3 (r = 0.541).
The results of the study suggest that salivary CA 15-3 may have potential use in the initial detection of breast cancer in women.
[show abstract][hide abstract] ABSTRACT: The aim of this study was to examine the relationship between serum and saliva levels of cancer antigen (CA) 125 and compare them among healthy women and patients with treated and untreated breast cancer.
CA125 levels were assayed in serum and unstimulated whole saliva of 25 normal healthy women, 24 patients with untreated breast cancer, and 23 patients with treated breast cancer using enzyme immunoassay (EIA) kits.
The mean saliva and serum CA125 levels were significantly higher in untreated cancer women compared to healthy and treated groups. The serum and saliva CA125 levels showed a significant modest positive correlation (r=0.38; p=0.01).
CA125 level in saliva is higher than in serum with a modest positive correlation between each other.
Serum and salivary CA125 levels were significantly higher in women with untreated breast cancer than healthy women and women who were treated for breast cancer.
The journal of contemporary dental practice 01/2009; 10(6):E001-8.