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Publications (10)4.41 Total impact

  • P Maheshwari, B Baburao, Ch Pradeep Kumar, A Rama Narsimha Reddy
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    ABSTRACT: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and its occurrence is increasing fast in most of the countries. Herbal medicine derived from plant extracts have been utilized increasingly for the treatment of various disorders like diabetes mellitus. The present study was designed to evaluate the antidiabetic activity of Methanolic Extract of Hiptage bengalensis L. Kurz (MEHB) in alloxan induced diabetic rats and chick model. Alloxan (120 mg kg-1) was used to induce diabetes in rats and the blood glucose levels were estimated by using commercial kit in the market. The methanolic extract of Hiptage bengalensis was administered to diabetic rats as single dose for one day at a dose of 100 and 200 mg kg-1. The extract produced a significant reduction (p<0.01) of blood glucose levels at a dose of 100 and 200 mg kg-1 in diabetic rats. It also showed a beneficial effect on the lipid profile in alloxan induced diabetic rats. These results showed that methanolic extract of Hiptage bengalensis produced a dose dependant antihyperglycemic activity in rats.
    Pakistan Journal of Biological Sciences 09/2013; 16(17):844-51.
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    ABSTRACT: Occupational exposure is unregulated in developing countries like India, and becoming the most common cause of disease of environmental origin. The present study was aimed to investigate the effects of occupational exposure on plasma lipid profiles, and risk of cardiovascular diseases. A total of 79 human volunteers were included in the study. Control subjects were healthy housewives of Karimnagar, India. Occupationally exposed individuals included different occupational workers like petrol station attendants, battery chargers, drivers, welders, pesticide-exposed workers, painters, and auto mechanics. These subjects were shown to be chronic occupationally-exposed for at least three years, and neither associated with any other chronic pathological conditions like hypertension or diabetes, nor under any medication other than analgesics during the month preceding the study. Subjects with excessive high or low caloric intake were excluded from the study. Total cholesterol (TC), LDL cholesterol, triglycerides (TG), VLDL cholesterol, LDL/HDL cholesterol, and TC/HDL ratio in these subjects were significantly higher than those in control subjects, whereas HDL cholesterol was not markedly affected. Blood pressure (systolic and diastolic), and other anthropometric parameters (body mass index (BMI), body fat index (BFI), body surface area (BSA)) were not significantly different between groups. Data suggest that chronic occupational exposure increases plasma lipid levels and is thereby associated with cardiovascular complications.
    Toxicological and Environmental Chemistry 01/2013; 95(2). · 0.72 Impact Factor
  • Ch. Tejasree, G. Kiran, G. Rajyalakshmi, A. Rama Narsimha Reddy
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    ABSTRACT: The aim of the present study was to evaluate the hepatoprotective activity of 1-(4-(dimethylamino)benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone, a novel isatin derivative against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Hepatic damage was induced by administration of CCl4 (1 ml/kg, b.w., p.o.) in combination with liquid paraffin (1:1) as a single dose. The hepatotoxic rats were treated with test compound at doses of 50 or 100 mg/kg for three days and liver damage biomarkers, including activities of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP), and levels of total serum bilirubin (TB) measured in blood samples. Results demonstrated that treatment with test compound at doses of 50 or 100 mg/kg to hepatotoxic rats produced a significant dose-dependent reduction of elevated SGOT, SGPT, ALP activities and TB levels indicating a hepatoprotective effect that was confirmed by histopathological examination of liver tissues. The study results confirmed the hepatoprotective activity of 1-(4-(dimethylamino)benzylidene)-5-(2-oxoindolin-3-ylidene) thiocarbohydrazone in rats.
    Toxicological and Environmental Chemistry 01/2013; 95(9). · 0.72 Impact Factor
  • P Maheshwari, B Baburao, A Rama Narsimha Reddy
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    ABSTRACT: The objective of the present study was to evaluate hepatoprotective activity of methanolic extract of Hiptage bengalensis (L.) kurz (MEHB) in rats. Hepatic damage was induced by administration of carbontetrachloride(1 ml/kg, b.w, p.o.) in combination with liquid paraffin (1:1) as a single dose on 7th day. The extent of liver damage was studied by estimating biochemical parameters. Administration of MEHB (200 mg & 400 mg/kg) for 6 days before carbontetrachloride administration showed a significant reduction (p < 0.01) of serum liver damage enzymes markers-aspartate transaminase, alanine transaminase, total bilirubin and alkaline phosphatase (ALP). Histopathological changes of hepatic tissue were also evaluated in control and MEHB treated groups. Results also indicated that MEHB possessed potential antioxidant effect by increasing the levels of glutathione and also possessed free radical scavenging activities. The hepatoprotective effect of Hiptage bengalensis (L.) kurz was comparable to standard drug silymarin (50 mg/kg).
    Toxicology mechanisms and methods 03/2012; 22(6):483-7. · 1.37 Impact Factor
  • G. Rajyalakshmi, A. Rama Narsimha Reddy, M. Sarangapani
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    ABSTRACT: A new series of 5- or 7-substituted 3-{4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenylimino}-indolin-2-one derivatives were screened for In vitro antioxidant and antimicrobial activities. The results of this study revealed that all synthesized compounds were significantly scavenged DPPH free radicals in a concentration-dependant manner. The IC50 values of all test compounds were found to be between 18.34 and 50.54 µM. All compounds significantly inhibited growth of bacteria and most of the minimum inhibitory concentration values were between 20 and 100 mg mL−1 indicating potent to moderate antibacterial activity. In conclusion, 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino)-5 or 7-substituted indolin-2-ones derivatives exhibited moderate antioxidant and antimicrobial activities.
    Toxicological and Environmental Chemistry 01/2012; 94(10). · 0.72 Impact Factor
  • A. Rama Narsimha Reddy, J. Nagaraju, G. Rajyalaksmi, M. Sarangapani
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    ABSTRACT: The present study was aimed to evaluate the cardioprotective activity of N-(benzo[d]oxazol-2-yl)-2-(5-bromo-2-oxoindolin-3-ylidene)hydrazinecarboxamide (coded as ARL) in rats. Doxorubicin (DOX) (15 mg kg−1, i.p, single dose) was used to induce cardiotoxicity in rats. Four groups of female Wistar albino rats were used. Group 1 was used as control (0.5% CMC, oral); the other groups were treated with DOX (single i.p. dosage of 15 mg kg−1) or DOX plus compound ARL (50 or 100 mg kg−1 day−1, p.o.), respectively. Animals were treated with ARL or CMC for 7 days. On 6th day, a single dose of DOX was administered to rats. Blood was collected on 7th day. Evaluation of cardioprotective activity was estimated using biochemical parameters including plasma aspartate aminotransferase, creatine kinase (CK-MB), lactate dehydrogenase (LDH), and triglycerides (TG) levels. Pretreatment with compound ARL significantly reduced the elevated levels of cardiotoxic biomarkers in plasma. DOX-induced depletion of glutathione levels in blood was significantly alleviated by pretreatment with compound ARL.
    Toxicological and Environmental Chemistry 01/2012; 94(10). · 0.72 Impact Factor
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    A. Shyam Sunder, A. Rama Narsimha Reddy, G. Kiran, S. Thirumurugu
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    ABSTRACT: The methanolic extract of Trianthema portulacastrum (Aizoaceae) was evaluated for antihyperlipidemic and antioxidant activity in high-fat-diet–induced hyperlipidemic rats. It was found that the extract caused a significant reduction in the lipid levels in hyperlipidemic rats and was comparable with the standard anti-hyperlipidemic drug atorvastatin. It was also found that the plant extract increased the liver antioxidant enzyme (catalase, superoxide dismutase, glutathione) levels while reducing the lipid peroxide (malondialdehyde) levels.
    Journal of Herbs Spices & Medicinal Plants 01/2010; 16:193-202.
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    ABSTRACT: The present study was aimed at evaluating the anticonvulsant activity of some new isatin-5-sulphonamide derivativesagainst maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as astandard. All the five test compounds were effectiveagainst electric shock and PTZ induced convulsions at a dose of 100mg/kg. The anticonvulsant activities of test compounds were comparable with standard anticonvulsant , Phenytoin.
    Journal of Pharmacy Research. 01/2009;
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    ABSTRACT: The aim of the present study was to evaluate the anti hyperglycemic activity of methanolic extract of leaves of Salacia fruticosa (Family:Hippocrataceae) in alloxan induced diabetic rats. The hyperglycemic rats were divided into different groups and were treated with methanolic extract of S. fruticosa at a dose of 125 & 250mg/kg. Treatment with extract produced a significant dose dependent reduction in blood glucose levels and this anti hyperglycemic activity was comparable with the reference standard, metformin. The results of the present study revealed the anti-diabetic activity of methanolic extract of leaves of Salacia fruticosa in alloxan induced diabetic rats.
    Drug Invention Today. 01/2009;
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    ABSTRACT: The present study was aimed at evaluating the In vitro free radical scavenging activity of some new isatin-5-sulphonamide derivatives using DPPH and H 2 O 2 methods. The free radical scavenging activity of test compounds was determined by DPPH, H 2 O 2 and nitric oxide radical scavenging methods. All the five test compounds showed dose dependent scavenging activity.
    Pharmacologyonline 01/2009; 1:540-545. · 0.16 Impact Factor