[Show abstract][Hide abstract] ABSTRACT: Diabetes is one of the major complications, the world faces today. Many reports suggest that Cinnamomum tamala (Lauraceae) has potent antidiabetic activity. The plant was selected based on their Ethno-pharmacological uses in traditional medicine. The present study focused on methanol and successive water extract of bark of Cinnamomum tamala was screened by using α-amylase inhibition assay for antidiabetic activity. The percentage inhibition values of methanol and successive water extract of bark of the Cinnamomum tamala were found 97.49% and 93.78% respectively. Similarly, IC50 values of methanol and successive water extract of the Cinnamomum tamala were found 1.80 and 5.53. The methanol extract of Cinnamomum tamala showed high potent activity than successive water extracts.
International Journal of Pharmaceutical and Biomedical Research (IJPBR). 01/2010;
[Show abstract][Hide abstract] ABSTRACT: The present study was aimed at assessing the hepatoprotective activity of 1:1:1 petroleum ether, diethyl ether, and methanol (PDM) extract of Scoparia dulcis L. against carbon tetrachloride-induced acute liver injury in mice.
The PDM extract (50, 200, and 800 mg/kg, p.o.) and standard, silymarin (100 mg/kg, p.o) were tested for their antihepatotoxic activity against CCl4-induced acute liver injury in mice. The hepatoprotective activity was evaluated by measuring aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total proteins in serum, glycogen, lipid peroxides, superoxide dismutase, and glutathione reductase levels in liver homogenate and by histopathological analysis of the liver tissue. In addition, the extract was also evaluated for its in vitro antioxidant activity using 1, 1-Diphenyl-2-picrylhydrazyl scavenging assay.
The extract at the dose of 800 mg/kg, p.o., significantly prevented CCl4-induced changes in the serum and liver biochemistry (P < 0.05) and changes in liver histopathology. The above results are comparable to standard, silymarin (100 mg/kg, p.o.). In the in vitro 1, 1-diphenyl-2-picrylhydrazyl scavenging assay, the extract showed good free radical scavenging potential (IC 50 38.9 +/- 1.0 mug/ml).
The results of the study indicate that the PDM extract of Scoparia dulcis L. possesses potential hepatoprotective activity, which may be attributed to its free radical scavenging potential, due to the terpenoid constituents.
Indian Journal of Pharmacology 06/2009; 41(3):110-4. · 0.58 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: The volatile oil obtained from the cones of Cupressus funebris by hydrodistillation was subjected to anti-inflammatory activity using carrageenan induced paw oedema model using albino mice, Diclofenac sodium was used as standard drug (25 mg/kg body weight, p.o.). The volatile oil (100 mg/kg body weight, p.o.) showed significant anti inflammatory activity.
[Show abstract][Hide abstract] ABSTRACT: Leaves of Atalantia monophylla are used in chronic rheumatism and paralysis. The Pharmacognostical studies like histological characters, leaf constants, ash values and extractive values of leaves of Atalantia monophylla Corr were carried out. The preliminary phytochemical analysis were also carried out.