ABSTRACT: The objective of the present study was to develop single unit gastroretentive drug delivery system of Famotidine. Famotidineis histamine H2 receptor antagonist. It is widely for duodenal ulcers, gastric ulcers, gastro esophageal reflux disease anderosive esophagitis. Famotidine is having a short biological half-life of 2.5-3.5 hrs. The gastroretentive drug deliverysystem can be retained in the stomach and assist in improving the oral sustained delivery of drugs. The floating matrix drugdelivery system of famotidine was prepared by using sodium alginate, HPMC K15M, sodium bicarbonate and citric acid.The formulated formulations showed good buoyancy, in vitro sustained release of famotidine and good stability at shortterm accelerated stability study.
Journal of Pharmacy Research. 01/2009;