Tara Tehrani

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States

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Publications (2)6.31 Total impact

  • Tara Tehrani, Jeffrey S Berns
    Seminars in Dialysis 01/2009; 22(1):99-101. DOI:10.1111/j.1525-139X.2008.00521.x · 2.07 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Contrast-induced nephropathy continues to be a common cause of in-hospital acute kidney injury. Published studies on pathogenesis, clinical significance, diagnosis, and preventive measures have dramatically increased significantly in the past several years. This review will focus on new developments in contrast-induced nephropathy. Studies on the clinical significance of contrast-induced nephropathy are reviewed along with initial reports of biomarkers in diagnosing this complication of iodinated contrast administration. Emerging literature on the relative nephrotoxicity of iso-osmolar versus low-osmolar contrast media and the value of bicarbonate hydration are discussed. More recent preventive measures using prostacyclin, 'statins', and erythropoietin are also reviewed. Contrast-induced nephropathy is an increasing cause of acute kidney injury and is associated with significant mortality and morbidity. Future developments in this field will focus on refining the clinical significance of this complication, earlier diagnosis with biomarkers, clarifying the role for bicarbonate and iso-osmolar contrast agents as preventive strategies, and the introduction of new prophylactic techniques on the basis of an improved understanding of pathogenesis at the cellular level.
    Current Opinion in Nephrology and Hypertension 12/2008; 17(6):616-23. DOI:10.1097/MNH.0b013e32830f45a3 · 4.24 Impact Factor

Publication Stats

27 Citations
6.31 Total Impact Points

Institutions

  • 2009
    • Hospital of the University of Pennsylvania
      • Division of Renal-Electrolyte and Hypertension
      Philadelphia, Pennsylvania, United States