Sanpeng Xu

Tongji Hospital, Wu-han-shih, Hubei, China

Are you Sanpeng Xu?

Claim your profile

Publications (3)5.27 Total impact

  • Qilin Ao · Ying Wang · Sanpeng Xu · Ye Tian · Wei Huang ·
    [Show abstract] [Hide abstract]
    ABSTRACT: EBV positive diffuse large B-cell lymphoma (DLBCL) can happen to the elderly, seldom to the young. The case of EBV positive DLBCL has rarely been reported in the adolescent. We report a rare case of EBV positive DLBCL in a 17-year-old man with normal immune state. He was diagnosed by morphology, immunohistochemistry, in situ hybridization for EBV, Flow cytometer, IG/TCR gene rearrangement and cytogenetic study. The occurrence of this case suggests that EBV-positive DLBCL can happen to adolescent patients with normal immune state and cytogenetic study takes an important role in the diagnosis of adolescent EBV-positive DLBCL.
    International Journal of Clinical and Experimental Medicine 01/2014; 7(1):307-311. · 1.28 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Mucinous cystadenocarcinoma (MCA) of the breast is extremely rare and was only recently described as a distinct variant of invasive ductal carcinoma of the breast. A case of MCA is reported in a 41-year-old woman. Mammographic and ultrasonographic examinations showed an irregularly shaped 10.0 × 8.0 × 5.5 cm lesion with patching calcification in the upper outer quadrant of the left breast. The gross examination revealed that the tumor has a well-circumscribed edge with a gelatinous cut surface and hemorrhage and necrosis were also noticed in the mass. Microscopically, the mass resembled mucinous cystic neoplasm of the ovary and pancreas closely, with cystic areas lined by columnar mucinous cells and associated with abundant extracellular and intracellular mucin, which is distinctively different from mucinous carcinoma with typically nests of low grade neoplastic cells floating in the mucin pool. The tumor cells were positive for CK7, CK20 and CDX2 were negative and displayed a typical immunophenotype of basal-like breast cancer (ER, PR, HER2 were negative, CK5/6 and EGFR were positive). Metastatic carcinoma was identified in three of 14 axillary lymph nodes. We describe here a very unusual case of breast MCA with basal-like immunophenotype.
    Pathology International 06/2012; 62(6):429-32. DOI:10.1111/j.1440-1827.2012.02810.x · 1.69 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Fibrinogen-like protein 2 (FGL2)/fibroleukin has been reported to play a vital role in the pathogenesis of some critical inflammatory diseases by possessing immunomodulatory activity through the mediation of "immune coagulation" and the regulation of maturation and proliferation of immune cells. We observed upregulated FGL2 expression in alveolar macrophages from peripheral lungs of chronic obstructive pulmonary disease (COPD) patients and found a correlation between FGL2 expression and increased macrophage activation markers (CD11b and CD14). The role of FGL2 in the activation of macrophages was confirmed by the detection of significantly decreased macrophage activation marker (CD11b, CD11c, and CD71) expression as well as the inhibition of cell migration and inflammatory cytokine (IL-8 and MMP-9) production in an LPS-induced FGL2 knockdown human monocytic leukemia cell line (THP-1). Increased FGL2 expression co-localized with upregulated phosphorylated p38 mitogen-activated protein kinase (p38-MAPK) in the lung tissues from COPD patients. Moreover, FGL2 knockdown in THP-1 cells significantly downregulated LPS-induced phosphorylation of p38-MAPK while upregulating phosphorylation of c-Jun N-terminal kinase (JNK). Thus, we demonstrate that FGL2 plays an important role in macrophage activation in the lungs of COPD patients through MAPK pathway modulation.
    Biochemical and Biophysical Research Communications 05/2010; 396(2):555-61. DOI:10.1016/j.bbrc.2010.04.145 · 2.30 Impact Factor

Publication Stats

11 Citations
5.27 Total Impact Points

Top co-authors View all


  • 2010-2012
    • Tongji Hospital
      Wu-han-shih, Hubei, China