Publications (2)1.73 Total impact
Article: Heparin induces apoptosis through suppression of AKt in oral squamous cell carcinoma cells.[show abstract] [hide abstract]
ABSTRACT: Heparin is a polysulfated glycosaminoglycan that has been shown to have antiproliferative and apoptotic effects in addition to its anticoagulant effects. The present work investigated the effects of unfractioned heparin (UFH) on cell growth and apoptosis in four oral squamous cell carcinoma (SCC) cell lines and the mechanism(s) underlying its actions using MTT assay, Annexin-V-FITC and Western blotting. Treatment with UFH resulted in significant reduction in cell viability and increase in apoptosis in three of the four tested cell lines. Further, such treatment resulted in a significant decrease in phosphorylated AKt, and consequently led to activation of the mitochondrial pathway in heparin-sensitive cells. Moreover, pretreatment with UFH significantly increased the apoptosis induced by cisplatin. These findings indicate that heparin induces apoptosis through suppression of AKt, and suggest a potential utility of heparin for development of less toxic chemotherapy in treatment of oral SCC.Anticancer research 05/2009; 29(4):1079-88. · 1.73 Impact Factor
Article: [Influence of malalignment and malocclusion on mental and physical health-consciousness in senior high school students].[show abstract] [hide abstract]
ABSTRACT: Dental examinations and a questionnaire survey were carried out simultaneously in senior high schools to investigate influence of tooth misalignment and malocclusion on mental and physical health-consciousness of the students. The questionnaire survey concerning health-consciousness was collected after the dental examination. The students were divided into three groups by their findings: "within a normal range"; "mild-", and "severe- misalignment and malocclusion". The relationship between the severity of dental abnormality and mental and physical status in health by the questionnaire survey was studied. The severity of misalignment and malocclusion correlated with (1) degree of consciousness of irregular teeth, and (2) degree of negative evaluation of themselves for their health-consciousness. There is possibility that the severity of misalignment and malocclusion corresponds to a negative self evaluation and causes mental stress. It is suggested that it is very important to identify young people with such problems at an early stage, and then to consult and promote correct dental alignment and occlusion, providing not only sufficient mastication but also unhampered mental development.[Nippon kōshū eisei zasshi] Japanese journal of public health 12/2008; 55(11):768-76.