Publications (2)5.34 Total impact
Article: Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study.[show abstract] [hide abstract]
ABSTRACT: The purpose of our study was to investigate alterations of white matter integrity in adults with major depressive disorder (MDD) using magnetic resonance imaging (MRI). We performed diffusion tensor imaging with a 3T MRI scanner on 45 patients with major depression and 45 healthy controls matched for age, sex and education. Using a voxel-based analysis, we measured the fractional anisotropy (FA), and we investigated the differences between the patient and control groups. We examined the correlations between the microstructure abnormalities of white matter and symptom severity, age of illness onset and cumulative illness duration, respectively. We found a significant decrease in FA in the left hemisphere, including the anterior limb of the internal capsule and the inferior parietal portion of the superior longitudinal fasciculus, in patients with MDD compared with healthy controls. Diffusion tensor imaging measures in the left anterior limb of the internal capsule were negatively related to the severity of depressive symptoms, even after we controlled for age and sex. Our findings provide new evidence of microstructural changes of white matter in non-late-onset adult depression. Our results complement those observed in late-life depression and support the hypothesis that the disruption of cortical- subcortical circuit integrity may be involved in the etiology of major depressive disorder.Journal of psychiatry & neuroscience: JPN 12/2008; 33(6):525-30. · 5.34 Impact Factor
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ABSTRACT: Diffusion tensor imaging (DTI) is a powerful technique for the assessment of white matter structural integrity and connectivity. There is a growing appreciation of the importance of connectivity to brain function. Disruption of this connectivity can result in brain dysfunction manifested in impaired cognitive functioning and the development of clinical symptoms. White matter forms the basis of anatomical connectivity. DTI is a useful tool for examining and quantifying white matter microstructure. Clinical research studies in alcoholism, HIV-1 infection, geriatric depression and schizophrenia using DTI have revealed abnormalities in white matter microstructure. The use of complementary imaging methods may be helpful in further characterizing these abnormalities. Other psychiatric disorders may also have white matter involvement amenable to study with DTI. Advances in acquisition and analysis methods will be necessary to further advance work in this field. In this paper, the voxel-based analysis in DTI is introduced to investigate the whole brain abnormalities between the refractory depression male patients and normal controls. The significant reduction of fractional anisotropy (FA) value is found in frontal lobe, anterior cingulated, Temporal Lobe and other regions in refractory depression patients, and no areas of significantly higher FA in patients compared with healthy volunteers. Our result supports the hypothesis that neuroanatomical circuit abnormality is a key factor in the functional anatomy of refractory depression.International Journal of Magnetic Resonance Imaging. 01/2007; 01:1749-8023.