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ABSTRACT: A rigid colloidal silica template was formed by self-assembly of the monodispersed silica spheres prepared according to Stöber
method. The silica template is highly ordered, which was verified by bright color effect due to Bragg diffraction and the
results of SEM. The free radical polymerization of styrene was allowed within the interstices of the rigid template to result
in the formation of the threedimensional periodic silica/polystyrene nano-composites. The titled porous polystyrene was prepared
by chemical decomposition of the template with concentrated aqueous hydrofluoric acid. Scanning electron microscopy characterization
showed that the macroporous polystyrene has ordered arrays of the uniform pores replicated from the template. Moreover, it
was found that the morphology of the as-synthesized macroporous polystyrene was greatly affected by the connectivity of the
silica spheres treated under different conditions.
Keywordstemplate synthesis-colloidal silica-three-dimensional order-macroporous polystyrene
Chinese Science Bulletin 05/2012; 46(4):306-308. · 1.32 Impact Factor
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ABSTRACT: Opal hydrogels could be synthesized with polymer inverse opal template. A pH responsive opal N-isopropylacrylamide/acrylic
acid copolymerized hydrogel was prepared as an example. The ordered structure and response to pH were investigated. Through
the sol-gel process of tetrabutyl titanate, opal titania was obtained with the opal hydrogel template.
Keywordshydrogels-templates-ordered-colloids-structures
Chinese Science Bulletin 04/2012; 48(17):1803-1806. · 1.32 Impact Factor
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Zhongwei Niu,
Saswat Kabisatpathy,
Jinbo He,
L. Andrew Lee, Jianhua Rong,
Lin Yang,
Godfrey Sikha,
Branko N. Popov,
Todd S. Emrick,
Thomas P. Russell,
Qian Wang
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ABSTRACT: A sol-gel process has been developed to incorporate bionanoparticles, such as turnip yellow mosaic virus, cowpea mosaic virus,
tobacco mosaic virus, and ferritin into silica, while maintaining the integrity and morphology of the particles. The structures
of the resulting materials were characterized by transmission electron microscopy, small angle X-ray scattering, and N2 adsorption-desorption analysis. The results show that the shape and surface morphology of the bionanoparticles are largely
preserved after being embedded into silica. After removal of the bionanoparticles by calcination, mesoporous silica with monodisperse
pores, having the shape and surface morphology of the bionanoparticles replicated inside the silica, was produced,. This study
is expected to lead to both functional composite materials and mesoporous silica with structurally well-defined large pores.
KeywordsMesoporous silica-bionanoparticles-virus-ferritin-sol-gel
Nano Research 04/2012; 2(6):474-483. · 6.97 Impact Factor
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08/2009: pages 1 - 29; , ISBN: 9783527627011
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ABSTRACT: Fibrillar M13 bacteriophages were used as basic building blocks to generate thin films with aligned nanogrooves, which, upon chemical grafting with RGD peptides, guide cell alignment and orient the cell outgrowth along defined directions.
Chemical Communications 12/2008; · 6.17 Impact Factor
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ABSTRACT: COMMUNICATION www.rsc.org/[journal] | [journal name] This journal is © The Royal Society of Chemistry [year] [journal], [year], [vol], 00–00 | 1 Thim films with aligned nanogrooves were fabricated using RGD-grafted fibrillar M13 bacteriphage as building blocks, which were used to guide the cell alignment and oriented growth along definite directions. 10 Cell behaviors are a complex orchestration of signaling between cell to cell and their surrounding extracellular matrix (ECM). Understanding the biological intricacies between the cell and ECM is critical to general biological questions and the design of functional scaffolds for tissue engineering. Patterning and 15 aligning scaffolds at micro-and nano-scales with topographical features (indentations or grooves) as well as ligand organization have been reported to influence cell responses, in particularly, the oriented cell growth.[1-4] Micro-contact printing, [5-7] photolithography [8] and electrospinning [9] have been 20 extensively used to design indentations and grooves at the micro-and nanoscale to systematically characterize cell behaviors towards such patterned surfaces. Here, we report a new system, the thin film derived from self-assembled bacteriophage M13, which can be employed as a new scaffold to direct cell growth. 25 For years, bacteriophages and other viruses have been utilized as drug delivery vehicles and vaccines, and in the past decade these particles are broadly exploited for material development. [10, 11] The relatively simple chemistry and the facile genetic reprogramming of viruses placed these biological materials in the 30 crosshairs of many material scientists to generate novel nanosized systems. M13 bacteriophage, in particular, has been extensively characterized over the past years for use in phage display and inorganic material deposition. [12] Its innate ability to organize into liquid crystalline, along with well-defined nanostructures, 35 highly evolved molecular cloning strategy, and rapid production in large quantities, the bacteriophage possesses many key features as a powerful building material. [13-17] In this study, we explored the M13 phage's natural tendency to form well-ordered films and the effects on cell behaviors. 40 To generate viral films, phage suspension was slowly dried in the well of the 12-well plate over three days to yield liquid crystalline films. Similar to previous reports of M13 viral films, [13] we obtained ordered patterns with light and dark band patterns that could be directly visualized under the optical 45 microscope (Fig. 1a). The periodic spacing of patterns was from 1 to 4 μm. The mammalian cell line, NIH-3T3 fibroblast was seeded on the viral films at 10×10 3 cell/cm 2 using standard methods. NIH-3T3 cells were maintained in DMEM (HyClone) supplemented with 10% neonatal calf serum and 4mM L-50
Chemical Communications 01/2008; · 6.17 Impact Factor
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Macromolecular Rapid Communications 10/2004; 25(20):1786 - 1791. · 4.60 Impact Factor
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ABSTRACT: Ordered arrays of oblate titania bodies were template synthesized using opal gel templates under uniaxial compression at ambient temperature during the favorable titania sol/gel process. The aspect ratio was controllable by the compression degree.
Chemical Communications 06/2003; · 6.17 Impact Factor
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ABSTRACT: Ordered silica/polystyrene composites were prepared via radical polymerization in silica colloidal crystal templates, and ordered macroporous polymers were accordingly obtained after removing the silica templates. The confinement effect of the templates on the polymers in the composites was investigated. NMR results indicated that the polystyrenes formed both inside and outside the template were atactic. The polystyrene inside the template possessed a higher molecular weight and a narrower molecular weight distribution than the bulk one outside the template. The glass transition temperature of the confined polystyrene increased significantly with decreasing silica sphere size of the templates, and so did the contraction of polymer pores. The smaller the silica sphere size of the templates, the more remarkable is the confinement, which could be explained by entropic confinement of the polymer chains within a fixed inorganic meso-framework (T. P. Russell, Science2001, 293, 446).
Macromolecular Materials and Engineering 02/2002; 287(1):11 - 15. · 1.99 Impact Factor
