Ayman F Abdel-Razik

Publications (2)5.65 Total impact

• Article: 9,11-Secosterols with antiproliferative activity from the gorgonian Eunicella cavolini.

  Efstathia Ioannou, Ayman F Abdel-Razik, Xanthippi Alexi, Constantinos Vagias, Michael N Alexis, Vassilios Roussis
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  ABSTRACT: Four new 9,11-secosterols (2, 4-6), along with two previously reported ones (1, 3) were isolated from the organic extract of the gorgonian Eunicella cavolini. The structures and relative configurations of the isolated natural products were established on the basis of detailed NMR spectroscopic analysis. Metabolites 1 and 2 were found to strongly inhibit the growth of LNCaP human prostate adenocarcinoma cells and the estrogen-dependent growth of MCF-7 human breast adenocarcinoma cells.
  Bioorganic & medicinal chemistry 08/2009; 17(13):4537-41. · 2.82 Impact Factor
• Article: 5alpha,8alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: isolation and evaluation of their antiproliferative activity.

  Efstathia Ioannou, Ayman F Abdel-Razik, Maria Zervou, Dimitrios Christofidis, Xanthippi Alexi, Constantinos Vagias, Michael N Alexis, Vassilios Roussis
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  ABSTRACT: Three new (1, 4, 9) and nine previously reported (2, 3, 5-8, 10-12) 5alpha,8alpha-epidioxysterols were isolated from the organic extracts of the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum. The structures and relative configurations of 1-12 were established on the basis of detailed NMR spectroscopic analyses and comparison with the literature. The growth inhibitory effects of 1-12 were evaluated against MCF-7 human breast cancer cells. Compound 1, bearing a cyclopropyl moiety in the side chain, exhibited the highest antiproliferative activity.
  Steroids 10/2008; 74(1):73-80. · 2.83 Impact Factor