-
[show abstract]
[hide abstract]
ABSTRACT: INTRODUCTION: Anti-tumour necrosis factor (anti-TNF-α) agents can be used successfully to treat patients with psoriasis and other inflammatory diseases. However, very few studies have examined the relationship between TNF-α polymorphisms and the response to anti-TNF-α agents. MATERIALS AND METHODS: Single nucleotide polymorphisms (SNPs) for TNF-α promoter and IL12B/IL23R genes, and presence of HLA-Cw6 haplotype were genotyped for 109 patients. We studied the association between these SNPs and the efficacy of treatment at 3 and 6 months (PASI and BSA). RESULTS: Patients with the TNF-α-238GG genotype more frequently achieved PASI75 at six months (82.5 vs. 58.8, p=0.049). At six months patients with the TNF-α-857CT/TT genotypes showed greater improvements in PASI and BSA (83.1 vs. 92.7, p=0.004; 82.7 vs. 92.6, p=0.009) and more frequently achieved PASI75 (71.4 vs. 96.3, p=0.006). More patients with the TNFα-1031TT genotype achieved PASI75 at three months (90.8 vs. 75.7, p=0.047) and six months (85.5 vs. 65.7, p=0.038) and demonstrated superior improvements in PASI at six months (89.9 vs. 78.7, p=0.041). Patients with the IL23R GG genotype (rs11209026) achieved PASI90 at six months (66.3 vs. 0, p=0.006) more frequently and the improvement of PASI was also greater (86.8 vs. 67.8, p=0.013). Patients with HLA-Cw6 haplotype showed poorer response than those without this haplotype. CONCLUSION: This study identified a relationship between certain TNF-α and IL12B/IL23R polymorphisms and the short-term response to anti-TNF-α drugs. If these results are confirmed, this information will allow for stratified consent with more accurate prediction of response/personalized choice of treatment hierarchy for the patient. This article is protected by copyright. All rights reserved.
British Journal of Dermatology 05/2013; · 3.67 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
R Loveless,
A Mohapatra,
M U Mozer,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A study is presented of the mass and spin-parity of the new boson recently observed at the LHC at a mass near 125 GeV. An integrated luminosity of 17.3 fb^{-1}, collected by the CMS experiment in proton-proton collisions at center-of-mass energies of 7 and 8 TeV, is used. The measured mass in the ZZ channel, where both Z bosons decay to e or μ pairs, is 126.2±0.6(stat)±0.2(syst) GeV. The angular distributions of the lepton pairs in this channel are sensitive to the spin-parity of the boson. Under the assumption of spin 0, the present data are consistent with the pure scalar hypothesis, while disfavoring the pure pseudoscalar hypothesis.
Physical Review Letters 02/2013; 110(8):081803. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Results are presented from a search for the pair production of third-generation scalar and vector leptoquarks, as well as for top squarks in R-parity-violating supersymmetric models. In either scenario, the new, heavy particle decays into a τ lepton and a b quark. The search is based on a data sample of pp collisions at sqrt[s]=7 TeV, which is collected by the CMS detector at the LHC and corresponds to an integrated luminosity of 4.8 fb^{-1}. The number of observed events is found to be in agreement with the standard model prediction, and exclusion limits on mass parameters are obtained at the 95% confidence level. Vector leptoquarks with masses below 760 GeV are excluded and, if the branching fraction of the scalar leptoquark decay to a τ lepton and a b quark is assumed to be unity, third-generation scalar leptoquarks with masses below 525 GeV are ruled out. Top squarks with masses below 453 GeV are excluded for a typical benchmark scenario, and limits on the coupling between the top squark, τ lepton, and b quark, λ_{333}^{'} are obtained. These results are the most stringent for these scenarios to date.
Physical Review Letters 02/2013; 110(8):081801. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
C Lazaridis,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The polarizations of the Υ(1S), Υ(2S), and Υ(3S) mesons are measured in proton-proton collisions at sqrt[s]=7 TeV, using a data sample of Υ(nS)→μ^{+}μ^{-} decays collected by the CMS experiment, corresponding to an integrated luminosity of 4.9 fb^{-1}. The dimuon decay angular distributions are analyzed in three different polarization frames. The polarization parameters λ_{ϑ}, λ_{φ}, and λ_{ϑφ}, as well as the frame-invariant quantity λ[over ˜], are presented as a function of the Υ(nS) transverse momentum between 10 and 50 GeV, in the rapidity ranges |y|<0.6 and 0.6<|y|<1.2. No evidence of large transverse or longitudinal polarizations is seen in the explored kinematic region.
Physical Review Letters 02/2013; 110(8):081802. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Evidence is presented for the associated production of a single top quark and W boson in pp collisions at sqrt[s]=7 TeV with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 4.9 fb^{-1}. The measurement is performed using events with two leptons and a jet originated from a b quark. A multivariate analysis based on kinematic properties is utilized to separate the tt[over ¯] background from the signal. The observed signal has a significance of 4.0σ and corresponds to a cross section of 16_{-4}^{+5} pb, in agreement with the standard model expectation of 15.6±0.4_{-1.2}^{+1.0} pb.
Physical Review Letters 01/2013; 110(2):022003. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
C Lazaridis,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: Results are presented from a search for heavy, right-handed muon neutrinos, N_{μ}, and right-handed W_{R} bosons, which arise in the left-right symmetric extensions of the standard model. The analysis is based on a 5.0 fb^{-1} sample of proton-proton collisions at a center-of-mass energy of 7 TeV, collected by the CMS detector at the Large Hadron Collider. No evidence is observed for an excess of events over the standard model expectation. For models with exact left-right symmetry, heavy right-handed neutrinos are excluded at 95% confidence level for a range of neutrino masses below the W_{R} mass, dependent on the value of M_{W_{R}}. The excluded region in the two-dimensional (M_{W_{R}}, M_{N_{μ}}) mass plane extends to M_{W_{R}}=2.5 TeV.
Physical Review Letters 12/2012; 109(26):261802. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: We report an investigation of the invariant mass spectrum of the two jets with highest transverse momentum in pp→W+2-jet and W+3-jet events to look for resonant enhancement. The data sample corresponds to an integrated luminosity of 5.0 fb^{-1} collected with the CMS detector at sqrt[s]=7 TeV. We find no evidence for the anomalous structure reported by the CDF Collaboration, and establish an upper limit of 5.0 pb at 95% confidence level on the production cross section for a generic Gaussian signal with mass near 150 GeV. Additionally, we exclude two theoretical models that predict a CDF-like dijet resonance near 150 GeV.
Physical Review Letters 12/2012; 109(25):251801. · 7.37 Impact Factor
-
D. Abbaneo,
G. Abbiendi,
M. Abbrescia,
S. Abdullin,
A. Abdulsalam,
B.S. Acharya,
D. Acosta,
J.G. Acosta,
A. Adair,
W. Adam, [......],
M.H. Zoeller,
O. Zorba,
P. Zotto,
W. Zou,
G. Zumerle,
M. Zupan,
A. Zuranski,
R. Zuyeuski,
M. Zvada,
P. Zych
[show abstract]
[hide abstract]
ABSTRACT: The Higgs boson was postulated nearly five decades ago within the framework of the standard model of particle physics and
has been the subject of numerous searches at accelerators around the world. Its discovery would verify the existence of a
complex scalar field thought to give mass to three of the carriers of the electroweak force—the W+, W–, and Z0 bosons—as well as to the fundamental quarks and leptons. The CMS Collaboration has observed, with a statistical significance
of five standard deviations, a new particle produced in proton-proton collisions at the Large Hadron Collider at CERN. The
evidence is strongest in the diphoton and four-lepton (electrons and/or muons) final states, which provide the best mass resolution
in the CMS detector. The probability of the observed signal being due to a random fluctuation of the background is about 1
in 3 × 106. The new particle is a boson with spin not equal to 1 and has a mass of about 1.25 giga–electron volts. Although its measured
properties are, within the uncertainties of the present data, consistent with those expected of the Higgs boson, more data
are needed to elucidate the precise nature of the new particle.
Science 12/2012; 338(6114):1569-1575. · 31.20 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The suppression of the individual Υ(nS) states in PbPb collisions with respect to their yields in pp data has been measured. The PbPb and pp data sets used in the analysis correspond to integrated luminosities of 150 μb^{-1} and 230 nb^{-1}, respectively, collected in 2011 by the CMS experiment at the LHC, at a center-of-mass energy per nucleon pair of 2.76 TeV. The Υ(nS) yields are measured from the dimuon invariant mass spectra. The suppression of the Υ(nS) yields in PbPb relative to the yields in pp, scaled by the number of nucleon-nucleon collisions, R_{AA}, is measured as a function of the collision centrality. Integrated over centrality, the R_{AA} values are 0.56±0.08(stat)±0.07(syst), 0.12±0.04(stat)±0.02(syst), and lower than 0.10 (at 95% confidence level), for the Υ(1S), Υ(2S), and Υ(3S) states, respectively. The results demonstrate the sequential suppression of the Υ(nS) states in PbPb collisions at LHC energies.
Physical Review Letters 11/2012; 109(22):222301. · 7.37 Impact Factor
-
H. Abramowicz,
I. Abt,
L. Adamczyk,
M. Adamus,
R. Aggarwal,
C. Alexa,
V. Andreev,
S. Antonelli,
P. Antonioli,
A. Antonov, [......],
W. Zeuner,
Z. Zhang,
B. O. Zhautykov,
N. Zhmak,
A. Zichichi,
R. Žlebčík,
H. Zohrabyan,
Z. Zolkapli,
F. Zomer,
D. S. Zotkin
[show abstract]
[hide abstract]
ABSTRACT: Measurements of open charm production cross sections in deep-inelastic ep
scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced
cross sections sigma_red^{c\bar{c}} for charm production are obtained in the
kinematic range of photon virtuality 2.5<Q2<2000 GeV2 and Bjorken scaling
variable 0.00003<x<0.05. The combination method accounts for the correlations
of the systematic uncertainties among the different data sets. The combined
charm data together with the combined inclusive deep-inelastic scattering cross
sections from HERA are used as input for a detailed NLO QCD analysis to study
the influence of different heavy flavour schemes on the parton distribution
functions. The optimal values of the charm mass as a parameter in these
different schemes are obtained. The implications on the NLO predictions for
W^{\pm} and Z production cross sections at the LHC are investigated. Using the
fixed flavour number scheme, the running mass of the charm quark is determined.
11/2012;
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A search for physics beyond the standard model is performed in events with at least three jets and large missing transverse momentum produced in proton-proton collisions at a center-of-mass energy of sqrt[s]=7 TeV. No significant excess of events above the expected backgrounds is observed in 4.98 fb^{-1} of data collected with the CMS detector at the Large Hadron Collider. The results are presented in the context of the constrained minimal supersymmetric extension of the standard model and more generically for simplified models. For the simplified models of gluino-gluino and squark-squark production, gluino masses below 1.0 TeV and squark masses below 0.76 TeV are excluded in case the lightest supersymmetric particle mass is below 200 GeV. These results significantly extend previous searches.
Physical Review Letters 10/2012; 109(17):171803. · 7.37 Impact Factor
-
ZEUS collaboration,
H. Abramowicz,
I. Abt,
L. Adamczyk,
M. Adamus,
R. Aggarwal,
S. Antonelli,
P. Antonioli,
A. Antonov,
M. Arneodo, [......],
O. Zabiegalov,
A. F. Żarnecki,
L. Zawiejski,
O. Zenaiev,
W. Zeuner,
B. O. Zhautykov,
N. Zhmak,
A. Zichichi,
Z. Zolkapli,
D. S. Zotkin
[show abstract]
[hide abstract]
ABSTRACT: The production of Z0 bosons in the reaction ep -> eZ0p*, where p* stands for
a proton or a low-mass nucleon resonance, has been studied in ep collisions at
HERA using the ZEUS detector. The analysis is based on a data sample collected
between 1996 and 2007, amounting to 496 pb-1 of integrated luminosity. The Z0
was measured in the hadronic decay mode. The elasticity of the events was
ensured by a cut on eta_max < 3.0, where eta_max is the maximum pseudorapidity
of energy deposits in the calorimeter defined with respect to the proton beam
direction. A signal was observed at the Z0 mass. The cross section of the
reaction ep -> eZ0p* was measured to be sigma(ep -> eZ0p*) = 0.13 +/- 0.06
(stat.) +/- 0.01 (syst.) pb, in agreement with the Standard Model prediction of
0.16 pb. This is the first measurement of Z0 production in ep collisions.
10/2012;
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The transverse energy (E_{T}) in Pb-Pb collisions at 2.76 TeV nucleon-nucleon center-of-mass energy (sqrt[s_{NN}]) has been measured over a broad range of pseudorapidity (η) and collision centrality by using the CMS detector at the LHC. The transverse energy density per unit pseudorapidity (dE_{T}/dη) increases faster with collision energy than the charged particle multiplicity. This implies that the mean energy per particle is increasing with collision energy. At all pseudorapidities, the transverse energy per participating nucleon increases with the centrality of the collision. The ratio of transverse energy per unit pseudorapidity in peripheral to central collisions varies significantly as the pseudorapidity increases from η=0 to |η|=5.0. For the 5% most central collisions, the energy density per unit volume is estimated to be about 14 GeV/fm^{3} at a time of 1 fm/c after the collision. This is about 100 times larger than normal nuclear matter density and a factor of 2.6 times higher than the energy density reported at sqrt[s_{NN}]=200 GeV at the Relativistic Heavy Ion Collider.
Physical Review Letters 10/2012; 109(15):152303. · 7.37 Impact Factor
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
E Aguilo,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: A search is performed in pp collisions at sqrt[s]=7 TeV for exotic particles decaying via WZ to final states with electrons and muons. The data sample corresponds to an integrated luminosity of approximately 5 fb^{-1}. No significant excess is observed in the data above the expected standard model background. Upper bounds at 95% confidence level are set on the production cross section of the W^{'} boson described by the sequential standard model and on the W^{'} WZ coupling. W^{'} bosons with masses below 1143 GeV are excluded. Limits are also set in the context of low-scale technicolor models, under a range of assumptions concerning the model parameters.
Physical Review Letters 10/2012; 109(14):141801. · 7.37 Impact Factor
-
ZEUS Collaboration,
H. Abramowicz,
I. Abt,
L. Adamczyk,
M. Adamus,
R. Aggarwal,
S. Antonelli,
P. Antonioli,
A. Antonov,
M. Arneodo, [......],
L. Zawiejski,
O. Zenaiev,
W. Zeuner,
B. O. Zhautykov,
N. Zhmak,
C. Zhou,
A. Zichichi,
Z. Zolkapli,
M. Zolko,
D. S. Zotkin
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
F Palmonari,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The dimuon invariant mass spectrum is searched in the range between 5.5 and 14 GeV for a light pseudoscalar Higgs boson a, predicted in a number of new physics models, including the next-to-minimal supersymmetric standard model. The data sample used in the search corresponds to an integrated luminosity of 1.3 fb^{-1} collected in pp collisions at sqrt[s]=7 TeV with the CMS detector at the LHC. No excess is observed above the background predictions and upper limits are set on the cross section times branching fraction σ×B(pp→a→μ^{+}μ^{-}) in the range of 1.5-7.5 pb. These results improve on existing bounds on the abb[over ¯] coupling for m_{a}<m_{Υ(1S)} and are the first significant limits for m_{a}>m_{Υ(3S)}. Constraints on the supersymmetric parameter space are presented in the context of the next-to-minimal model.
Physical Review Letters 09/2012; 109(12):121801. · 7.37 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: Canine visceral leishmaniasis frequently causes renal damage that leads to chronic kidney disease. Fifteen dogs seropositive for Leishmania were selected and biopsied before (T0) and 60 days later after (T1) treatment with a specific anti-Leishmania pharmacological agent. Various parameters were selected for evaluating the glomerular and tubulointerstitial damage. At T0, mesangioproliferative and membranoproliferative glomerulonephritis were observed in 6 dogs, chronic glomerulosclerosis in 5, and end-stage kidney in 3; renal tissue from 1 dog was within normal histologic limits. The most frequently observed ultrastructural changes were foot-process effacement, thickening of the basement membranes, and immune deposits. One dog had mesangial immune deposits at T1 that had not been present at T0, so the diagnosis was changed to mesangioproliferative glomerulonephritis. In dogs with end-stage kidney, the number of obsolescent glomeruli and cystic atrophied glomeruli was increased at T1. However, progression of the glomerular lesions was minimal in most dogs. Worsening of tubulointerstitial scores was evident in the dogs with the most severe lesions at the first biopsy. Progression of the tubulointerstitial damage was minimal in the mildly affected dogs, and the interstitial inflammation was abated. In conclusion, renal lesions can progress over a 60-day period in canine leishmaniasis. A longer period between the renal biopsies would be necessary to demonstrate more severe changes. In addition a specific anti-Leishmania treatment could have a significant effect in the early stages of the disease.
Veterinary Pathology 09/2012; · 1.95 Impact Factor
-
H. Abramowicz,
I. Abt,
L. Adamczyk,
M. Adamus,
R. Aggarwal,
S. Antonelli,
P. Antonioli,
A. Antonov,
M. Arneodo,
O. Arslan, [......],
A. F. Żarnecki,
L. Zawiejski,
O. Zenaiev,
W. Zeuner,
B. O. Zhautykov,
N. Zhmak,
C. Zhou,
A. Zichichi,
Z. Zolkapli,
D. S. Zotkin
[show abstract]
[hide abstract]
ABSTRACT: A search for first-generation leptoquarks was performed in electron-proton and positron-proton collisions recorded with the ZEUS detector at HERA in 2003–2007 using an integrated luminosity of 366 pb-1. Final states with an electron and jets or with missing transverse momentum and jets were analyzed, searching for resonances or other deviations from the standard model predictions. No evidence for any leptoquark signal was found. The data were combined with data previously taken at HERA, resulting in a total integrated luminosity of 498 pb-1. Limits on the Yukawa coupling, λ, of leptoquarks were set as a function of the leptoquark mass for different leptoquark types within the Buchmüller-Rückl-Wyler model. Leptoquarks with a coupling λ=0.3 are excluded for masses up to 699 GeV.
Phys. Rev. D. 07/2012; 86(1).
-
S Chatrchyan,
V Khachatryan,
A M Sirunyan,
A Tumasyan,
W Adam,
T Bergauer,
M Dragicevic,
J Erö,
C Fabjan,
M Friedl, [......],
C Lazaridis,
J Leonard,
R Loveless,
A Mohapatra,
I Ojalvo,
G A Pierro,
I Ross,
A Savin,
W H Smith,
J Swanson
[show abstract]
[hide abstract]
ABSTRACT: The azimuthal anisotropy of charged particles in Pb-Pb collisions at sqrt[s_{NN}]=2.76 TeV is measured with the CMS detector at the LHC over an extended transverse momentum (p_{T}) range up to approximately 60 GeV/c. The data cover both the low-p_{T} region associated with hydrodynamic flow phenomena and the high-p_{T} region where the anisotropies may reflect the path-length dependence of parton energy loss in the created medium. The anisotropy parameter (v_{2}) of the particles is extracted by correlating charged tracks with respect to the event-plane reconstructed by using the energy deposited in forward-angle calorimeters. For the six bins of collision centrality studied, spanning the range of 0-60% most-central events, the observed v_{2} values are found to first increase with p_{T}, reaching a maximum around p_{T}=3 GeV/c, and then to gradually decrease to almost zero, with the decline persisting up to at least p_{T}=40 GeV/c over the full centrality range measured.
Physical Review Letters 07/2012; 109(2):022301. · 7.37 Impact Factor
-
[show abstract]
[hide abstract]
ABSTRACT: BACKGROUND: Several studies have reported an association between tumor necrosis factor α (TNF-α) polymorphisms and inflammatory diseases such as psoriasis vulgaris and psoriatic arthritis, although the results vary according to the population studied. No studies have been performed in the Spanish population. OBJECTIVE: To analyze the polymorphisms of the promoter region of the TNF-α gene in patients with moderate to severe psorasis and to identify potential differences in genotype compared to a group of healthy volunteers. MATERIAL AND METHODS: Eighty-nine patients with moderate to severe psoriasis and 76 healthy controls with no personal or family history of psoriasis were selected. Polymorphisms of the TNF-α promoter region of both groups were genotyped. RESULTS: We observed a higher prevalence of the genotype with both wild-type alleles at positions -238 (GG genotype, 86.5% vs 70.4%, respectively) and -1031 (TT genotype, 80.2% vs 45.8%, respectively) in patients compared to the healthy control group. The differences at positions -308 and -857 were not significant. CONCLUSION: There are differences in polymorphisms at positions -238 and -1031 in patients with moderate to severe psoriasis compared to healthy volunteers. This observation provides further support for the importance of the part that TNF-α plays in the pathophysiology of this disease.
Actas Dermo-Sifiliográficas 06/2012;
