Publications (3)3.14 Total impact
-
Article: [Prognostic value of erythrocyte polyamines levels in renal cell carcinoma. Prospective study in 418 cases].
[show abstract] [hide abstract]
ABSTRACT: Polyamines: Spermine (Spm) and Spermidine (Spmd), are essential for cell proliferation and differentiation. A measurement of erythocytes polyamines (EPA) was developed in our institution. Our objective was to evaluate this marker as a new prognostic factor in renal cell carcinoma. A blood sample was prospectively taken before surgery, among 418 patients who had an enlarged nephrectomy (n=318) or a partial nephrectomy (n=100) to quantify EPA rates by using the HPLC technique. The qualitative and quantitative variables have been compared using chi(2) and Student statistical analyses. The survivals have been normalized by the Kaplan Meier and Cox methods. The average age of our population was 64 years (21-88). The average decline was 41 months (1-214). The median size of tumors was 6.5cm (1-24). The median rate of Spm and Spmd were respectively 4.7 (1-83) and 9 (2-86)nmol/8.10(9) erythrocytes. Spm and Spmd were linked to the T stage (p=0.001), and the ECOG (p=0.001 and 0,008). Spm was not linked at N and M stages but at the Fuhrman grade (p=0.001). Spmd was linked to the N, M stages (p=0.04). With univariate analysis, the tumor diameter, the TNM stage, the Fuhrman grade as well as Spm and Spmd (p<0.0001) were predictors of specific survival. With multivariate analysis, some prognostic factors remained independent: the TNM stage, the ECOG and Spmd, a continuous variable (p=0.0001), pushing the rank of Fuhrman out of the model. When Spm and Spmd were dichotomized in quantitative variables, they were both independent factors. The EPA is a new prognostic tool, before surgery, which will be tested for its integration into prognostic normograms.Progrès en Urologie 04/2010; 20(4):272-8. · 0.58 Impact Factor -
Article: The use of partial nephrectomy in European tertiary care centers.
[show abstract] [hide abstract]
ABSTRACT: The objective was to define the trends of PN use over time at six tertiary care European centers. Data were retrieved from institutional databases for patients treated with either PN or radical nephrectomy (RN) for stages T(1-2)N(0)M(0) renal cell carcinoma (RCC) between 1987 and 2007. For purpose of temporal trend analyses patients were divided into five equally sized groups according to the date of surgery. Categorical and multivariable logistic regression analyses assessed predictors of PN use. Overall 597 (31.7%) patients were treated with PN. Overall, a 4.5-fold increase of PN was recorded. The absolute increases were 41.7-86.3%, 14.9-69.3% and 8.1-35.3% for lesions < or = 2 cm, 2.1-4 cm and 4.1-7 cm (chi-square trend test p<0.001), respectively. In multivariable logistic regression models, decreasing tumor size, younger age, more contemporary date of surgery, male gender and institutional PN rate represented independent predictors of the individual probability of treatment with PN. Lack of data from community hospitals limits the generalizability of our findings. Based on data from six tertiary care centers, the contemporary rate of PN ranges from 86 to 35% for renal masses < or = 2 cm to 4.1-7 cm and is indicative of excellent quality of care.European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 09/2008; 35(6):636-42. · 2.56 Impact Factor -
Article: Valeur pronostique des polyamines érythrocytaires dans le cancer du rein. Étude chez 418 patients
[show abstract] [hide abstract]
ABSTRACT: Objectives Polyamines: Spermine (Spm) and Spermidine (Spmd), are essential for cell proliferation and differentiation. A measurement of erythocytes polyamines (EPA) was developed in our institution. Our objective was to evaluate this marker as a new prognostic factor in renal cell carcinoma.Patients and methodsA blood sample was prospectively taken before surgery, among 418 patients who had an enlarged nephrectomy (n = 318) or a partial nephrectomy (n = 100) to quantify EPA rates by using the HPLC technique. The qualitative and quantitative variables have been compared using chi2 and Student statistical analyses. The survivals have been normalized by the Kaplan Meier and Cox methods.ResultsThe average age of our population was 64 years (21–88). The average decline was 41 months (1–214). The median size of tumors was 6.5 cm (1–24). The median rate of Spm and Spmd were respectively 4.7 (1–83) and 9 (2–86) nmol/8.109 erythrocytes. Spm and Spmd were linked to the T stage (p = 0.001), and the ECOG (p = 0.001 and 0,008). Spm was not linked at N and M stages but at the Fuhrman grade (p = 0.001). Spmd was linked to the N, M stages (p = 0.04). With univariate analysis, the tumor diameter, the TNM stage, the Fuhrman grade as well as Spm and Spmd (p < 0.0001) were predictors of specific survival. With multivariate analysis, some prognostic factors remained independent: the TNM stage, the ECOG and Spmd, a continuous variable (p = 0.0001), pushing the rank of Fuhrman out of the model. When Spm and Spmd were dichotomized in quantitative variables, they were both independent factors.Conclusion The EPA is a new prognostic tool, before surgery, which will be tested for its integration into prognostic normograms.Progrès en Urologie. 20(4):272-278.
