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ABSTRACT: Sarcoidosis is a systemic disease with a 90% predilection for the lungs, but any organ can be involved. Gastrointestinal involvement is rare. Within the gastrointestinal system, gastric involvement is the most common. When this organ system is involved, it can be a feature of systemic disease or an isolated case. Gastrointestinal sarcoid can resemble a broad spectrum of other disease processes; thus, it is important for health care providers to be familiar with the various gastrointestinal manifestations. Patients can have subclinical symptoms or have symptoms of epigastric pain, nausea, vomiting, and hematemesis. We present 2 cases of gastric sarcoid and a MEDLINE search of 44 reported cases of gastric sarcoid based on a compatible history and the demonstration of noncaseating granulomas. We describe the clinical manifestations of symptomatic gastric sarcoid in relation to the endoscopic findings.
Journal of the National Medical Association 05/2010; 102(5):419-22. · 1.16 Impact Factor
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ABSTRACT: Diffuse interstitial pulmonary amyloidosis is a fatal disorder that is rare and often undiagnosed. There are many documented cases of diffuse interstitial amyloid occurring with systemic amyloid light-chain amyloid. We present an extraordinary case of localized interstitial amyloidosis, making our case the eleventh documented in the literature.
We review the subtypes of tracheobronchial-pulmonary amyloidosis and their clinical presentations. There is also a thorough investigation of the literature published on localized diffuse interstitial pulmonary amyloid, and we provided information on the recent advances in treatment and diagnosis of amyloid.
Although localized diffuse interstitial amyloid is a rare finding, it is often not placed in the differential diagnosis, leading to the diagnosis being made at autopsy. With the use of new techniques and fiberoptic bronchoscopy an early diagnosis can be made. More research needs to be dedicated to the advancement of treatment for this fatal disease.
Current opinion in pulmonary medicine 06/2009; 15(5):517-20. · 3.08 Impact Factor
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ABSTRACT: Community-acquired pneumonia is the most common manifestation in primary coccidioides infections (Coccidioides immitis, C. posadasii). It is essential that this endemic dimorphic fungus be considered in order to proceed with the most appropriate diagnostic tools and therapy.
We present a rare case of primary pleural coccidioides and a review of the current literature for optimal diagnostic methods and therapeutic strategies.
With increased domestic and international travel, coccidioidomycosis will likely be encountered in nonendemic regions. Recognition by physicians is critical for a timely diagnosis and therapy. Tissue culture can assist in the diagnosis and polymerase chain reaction analysis shows potential as a possible addition.
Journal of Medical Case Reports 10/2008; 2:291.
