Yiyu Hu

Sichuan University, Hua-yang, Sichuan, China

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Publications (3)11.65 Total impact

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    ABSTRACT: Some categories of compounds, including quinones, coumarins, flavins, and xanthene dyes, were found to produce strong chemiluminescence (CL) signals with luminol in sample solution under the irradiation of light emitting diodes (LED) with proper wavelengths. Based on this phenomenon, a compact photochemical reactor was constructed to develop a novel LED induced CL detector for high performance liquid chromatography (HPLC). The effects of related parameters including LED wavelength, luminol concentration, flow rate, pH, and eluents of HPLC were investigated in detail. Under the optimized conditions, the limits of detections (LODs) were in the range of 0.2-80 ng mL(-1). The applications and accuracy of the proposed method were validated by analyzing food samples such as milk powder, beer, candy and beverage with satisfactory results.
    Journal of Chromatography A 10/2009; 1216(51):8926-32. DOI:10.1016/j.chroma.2009.10.060 · 4.17 Impact Factor
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    ABSTRACT: A new capillary zone electrophoresis method with laser-induced fluorescence detection is presented for the determination of noradrenaline (NA) and dopamine (DA). The fluorescent reagent, 5-(4,6-dichloro-s-triazin-2-ylamino) fluorescein, which readily reacts with amine group under mild conditions, was initially used to label the two compounds. Under optimized separation and labeling conditions, linear relationship between peak area and analyte concentration was obtained with high sensitivity (nM level). The applicability of the method for complex sample analysis was validated by determining the two compounds in a human serum and an herb, Portulaca oleracea L with recoveries ranging from 89% to 102%.
    Microchimica Acta 09/2009; 166(3):289-294. DOI:10.1007/s00604-009-0198-3 · 3.74 Impact Factor
  • Jiyou Zhang · Yiyu Hu · Jiaqin Liu · Zhide Hu
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    ABSTRACT: Derivative spectrophotometry is introduced for the quantification of overlapping peaks in capillary electrophoresis. The application for resolving overlapping peaks is tested using eleven benzoic acids as examples. Compared with common spectrophotometric detection, the derivative mode has slightly lower reproducibility, comparable sensitivity but much higher separation efficiency as the peak is much sharpened. Derivative spectrophotometry offers the advantages of reagent-, time- and labor-saving since only few optimizations of separation conditions for normal CE are essential to make the peaks partly baseline-resolved. Analysis of real samples using the method was also performed and results obtained give evidence of the potential for improved quantification without loss in accuracy.
    Microchimica Acta 02/2009; 164(3):487-491. DOI:10.1007/s00604-008-0088-0 · 3.74 Impact Factor