Debasis Samanta

Publications (6)27.31 Total impact

• Article: Pentafluorophenyl ester-functionalized phosphorylcholine polymers: preparation of linear, two-arm, and grafted polymer-protein conjugates.

  Samantha McRae, Xiangji Chen, Katrina Kratz, Debasis Samanta, Elizabeth Henchey, Sallie Schneider, Todd Emrick
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  ABSTRACT: Novel pentafluorophenyl (PFP)-ester-functionalized phosphorylcholine (PC) polymers of different architectures were prepared and conjugated to lysozyme as a model protein. Linear and two-arm poly(2-methacryloyloxyethyl phosphorylcholine) (polyMPC) structures containing PFP functionality at the chain-end were prepared by atom transfer radical polymerization (ATRP) from novel initiators. Additional conjugates were prepared from phosphorylcholine-substituted cyclooctene (PC-COE) polymers containing PFP-ester bearing comonomers. The polymer-protein conjugates were characterized by HPLC, FPLC, and DLS and were seen to retain most (~80% or greater) of their native enzymatic activity. Pharmacokinetic profiles of the polymer-protein conjugates were studied in mice and found to increase the circulation half-life compared with lysozyme alone.
  Biomacromolecules 06/2012; 13(7):2099-109. · 5.48 Impact Factor
• Article: Ferritin–Polymer Conjugates: Grafting Chemistry and Integration into Nanoscale Assemblies

  Yunxia Hu, Debasis Samanta, Sangram S. Parelkar, Sung Woo Hong, Qian Wang, Thomas P. Russell, Todd Emrick
  Advanced Functional Materials 08/2010; 20(20):3603 - 3612. · 10.18 Impact Factor
• Article: Polymer−Protein Conjugation in Ionic Liquids

  Xiangji Chen, Samantha McRae, Debasis Samanta, Todd Emrick
  07/2010;
• Article: Polyester-graft-phosphorylcholine prepared by ring-opening polymerization and click chemistry.

  Beth M Cooper, Delphine Chan-Seng, Debasis Samanta, Xiongfei Zhang, Sangram Parelkar, Todd Emrick
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  ABSTRACT: Phosphorylcholine (PC)-substitution on aliphatic polyesters is accomplished by click chemistry with PC-substituted azides.
  Chemical Communications 03/2009; · 6.17 Impact Factor
• Article: End-functionalized phosphorylcholine methacrylates and their use in protein conjugation.

  Debasis Samanta, Samantha McRae, Beth Cooper, Yunxia Hu, Todd Emrick, Jeanne Pratt, Stephen A Charles
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  ABSTRACT: Polymer-protein conjugation was performed using N-hydroxysuccinimide and aldehyde-terminated zwitterionic polymers, and the resulting polymer-protein conjugates were characterized by gel electrophoresis and fast protein liquid chromatography. Methacryloyloxyethyl phosphorylcholine (MPC) polymers were prepared by atom transfer radical polymerization in which the requisite functional end-groups for protein conjugation were embedded within the polymerization initiators. These phosphorylcholine polymers were conjugated to lysozyme as a model protein, as well as two therapeutic proteins, granulocyte colony stimulating factor (G-CSF) and erythropoietin (EPO). These MPC polymer-protein conjugates represent alternatives to PEGylated proteins, with the potential to provide improved efficacy in a therapeutic treatment relative to the protein itself.
  Biomacromolecules 10/2008; 9(10):2891-7. · 5.48 Impact Factor
• Article: A Synthesis of PEG- and Phosphorylcholine-Substituted Pyridines To Afford Water-Soluble Ruthenium Benzylidene Metathesis Catalysts

  Debasis Samanta, Katrina Kratz, Xiongfei Zhang, Todd Emrick
  01/2008;