Publications (1)5.86 Total impact
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Article: Synthesis of 1,1-disubstituted olefins via catalytic alkyne hydrothiolation/Kumada cross-coupling.
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ABSTRACT: Using recently developed methodology for the regioselective formation of branched alkyl vinyl sulfides, we report a convenient route to 1,1-disubstituted olefins. We demonstrate that n-propanethiol successfully undergoes catalytic alkyne hydrothiolation with both aryl and aliphatic alkynes using Tp*Rh(PPh3)2 as the catalyst. The resulting vinyl sulfides undergo Kumada cross-coupling to afford the desired disubstituted alkene. Both two-step and one-pot procedures are reported.Organic Letters 09/2008; 10(18):3941-4. · 5.86 Impact Factor
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- Organic Letters (1)
Institutions
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2008
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University of British Columbia - Vancouver
- Department of Chemistry
Vancouver, British Columbia, Canada
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