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ABSTRACT: Secondary cervical adenocarcinomas are most commonly seen owing to the extension of a primary endometrial adenocarcinoma. Metastatic tumors from other sites are rather uncommon and, when seen, are most frequently from the ovaries, gastrointestinal tract, or breast. We report a case of metastatic renal cell carcinoma, clear cell variant, to the cervix, which presented as a cervical polyp in a postmenopausal female. To our knowledge, this is the fourth reported case of renal cell carcinoma metastatic to the cervix. This case is only the third in which the cervical metastasis was the presenting sign of renal cell carcinoma and the first in which the clinical presentation was as a cervical polyp.
Journal of Lower Genital Tract Disease 10/2010; 14(4):387-9. · 1.07 Impact Factor
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ABSTRACT: A solid right adnexal mass in a 73-year-old woman bled profusely with mobilization mimicking a granulosa cell tumor. There was almost complete replacement of the ovary by a circumscribed, 4.0 cm tumor with a hemorrhagic, solid cut surface. Morphologic and phenotypic correlation supported a diagnosis of glomus tumor. Large gaping vessels and small sinusoidal-type vessels formed an anastomotic vascular network with an inner endothelial lining (CD31+/CD34+) and an outer layer of glomocytes (actin+/desmin-/inhibin-). The hemangiopericytoma-like vasculature accounted for bleeding during surgery.
International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists 11/2009; 29(1):24-6. · 2.07 Impact Factor
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ABSTRACT: Human lung cancer is the leading cause of cancer death worldwide. Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), in combination with chemotherapy showed significant therapeutic efficacy in human lung cancer patients. However, increased adverse effects limit its clinical utilization. Previous studies demonstrated that polysaccharide beta-glucan significantly augments antitumor monoclonal antibody-mediated efficacy via stimulation of the innate effector neutrophil complement receptor 3. Here, we explored combined beta-glucan with bevacizumab therapy for human lung cancer using murine xenograft models. To that end, human lung adenocarcinomas were screened for membrane-bound VEGF expression. Both subcutaneous and orthotopic lung cancer xenograft models were used to evaluate the combination therapy. We found that PC14PE6 adenocarcinoma cells express membrane-bound VEGF both in vitro and in vivo. Bevacizumab bound to surface VEGF on PC14PE6 cells and activated complement. In the subcutaneous PC14PE6 tumor model, beta-glucan plus bevacizumab showed augmented efficacy in terms of tumor progression and long-term survival compared with bevacizumab-treated alone. These effects were accompanied with massive complement deposition and neutrophil infiltration within tumors. However, this effect was not observed in surface-bound VEGF-negative human lung tumors. Therapeutic efficacy of beta-glucan with bevacizumab was further demonstrated in an orthotopic lung cancer model. Thus, our data suggest that beta-glucan enhances bevacizumab-mediated efficacy and may provide therapeutic benefits for lung cancers with membrane-bound VEGF expression.
Journal of immunotherapy (Hagerstown, Md.: 1997) 07/2009; 32(7):703-12. · 3.20 Impact Factor
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ABSTRACT: Intranuclear biotin interacts with avidin-biotin-complex used for viral immunoperoxidase detection giving false-positive results.
International Journal of Surgical Pathology 08/2008; 16(4):424-5. · 1.00 Impact Factor
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ABSTRACT: Epidermoid metaplasia of the uterine cervix and vagina has previously been described, yet few well-documented cases exist. The tendency of the cervical and vaginal epithelium to undergo reactive changes as, for example, adenosis, squamous hyperplasia, hyperkeratosis, and parakeratosis is well known. Such changes can be secondary to uterine prolapse or to other causes that produce continuous irritation. The presence of ectodermal appendages (e.g., sebaceous glands and/or hair follicles), on the other hand, is less common. This is an interesting phenomenon, specially taken into consideration that the embryologic origin of the cervix and upper third of the vagina is from the mullerian duct.
We present and discuss the case of a 70-year-old patient that, on routine gynecologic examination, showed whitish areas on the upper vagina and cervix. Biopsies from such areas demonstrated melanin pigment in the basal squamous epithelium, hyperkeratosis, and hair follicles with associated sebaceous glands.
The presence of ectodermal structures in the cervix and upper vagina can be seen and is still an unresolved issue. To the authors, this phenomenon probably represents metaplastic changes instead of a developmental abnormality.
Journal of Lower Genital Tract Disease 08/2008; 12(3):217-9. · 1.07 Impact Factor
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