Lei Wu

Publications (2)5.45 Total impact

• Article: Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis.

  Dan Zhu, Lei Wu, Chun-Rong Li, Xiao-Wei Wang, Yong-Jie Ma, Zhi-Yin Zhong, Hai-Bao Zhao, Jian Cui, Si-Fan Xun, Xiu-Lan Huang, Zhe Zhou, Sheng-Qi Wang
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  ABSTRACT: Ginsenoside Rg1 is a major active ingredient of Panax notoginseng radix which has demonstrated a number of pharmacological actions including a cardioprotective effect in vivo. This study investigated the protective effect and mechanism of ginsenoside Rg1 in cardiomyocytes hypoxia/reoxygenation (H/R) model. Pretreatment with ginsenoside Rg1 (60-120 microM) reduced lactate dehydrogenase release and increased cell viability in a dose-dependent manner. Fluorescence analysis demonstrated ginsenoside Rg1 reduced intracellular ROS and suppressed the intracellular [Ca(2+)] level. Cell lysate detected an increase of T-SOD, CAT, and GSH levels. The myocardial protection of ginsenoside Rg1 during H/R is partially due to its antioxidative effect and intracellular calcium homeostasis.
  Journal of Cellular Biochemistry 07/2009; 108(1):117-24. · 2.87 Impact Factor
• Article: WITHDRAWN: Tanshinone IIA protects rat cardiomyocytes against apoptosis induced by angiotensin II in vitro.

  Xiao-Wei Wang, Lei Wu, Ming-San Miao, Dan Zhu, Ya-Ling Xing, Yong-Jie Ma, Zhi-Yin Zhong, Zhe Zhou, Sheng-Qi Wang
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  ABSTRACT: This article has been withdrawn at the request of the authors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
  European journal of pharmacology 08/2008; · 2.59 Impact Factor