D Davi

Publications (2)5.04 Total impact

• Source

  Available from: Nereo Segnan

  Article: Do women >or=50 years of age need as much screening as women <50 years after they have had negative screening results?

  P Armaroli, F Gallo, A Bellomi, S Ciatto, D Consonni, D Davi, P Giorgi-Rossi, A Iossa, E Mancini, C Naldoni, E Polla, G Ronco, M Serafini, V Vergini, L Zanier, M Zappa, N Segnan
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  ABSTRACT: To assess the adequacy of a routine screening to identify cervical intraepithelial neoplasia 2 or worse (CIN2+) in women over 50 years of age, a retrospective cohort was set in six Italian organised population-based screening programmes. In all, 287 330 women (1 714 550 person-years of observation, 1110 cases) screened at age 25-64, with at least two cytological screening tests, the first negative, were followed from their first negative smear until a biopsy proven CIN2+ lesion or their last negative smear. For women aged 25-49 and 50-64 years, crude and age-standardised detection rate (DR), cumulative risk (CR), adjusted hazard risk for number of previous negative screens, probability of false-positive CIN2+ after two or more smear tests were calculated. Detection rate is significantly lower over 50 years of age. Multivariable analysis shows a significant protective effect from four screening episodes (DR=0.70, 95% CI: 0.51-0.97); the effect of age >or=50 is 0.29 (95% CI: 0.24-0.35). The CR of CIN2+ is at least eightfold higher in women <50 (CR=2.06, 95% CI: 1.88-2.23) after one previous negative test than in women >or=50 years with four screens (CR=0.23, 95% CI: 0.00-0.46). Over 50 years of age, after four tests at least three false-positive cases are diagnosed for every true positive. Benefits arising from cytological screening is uncertain in well-screened older women.
  British Journal of Cancer 08/2008; 99(2):239-44. · 5.04 Impact Factor
• Article: Do women ⩾50 years of age need as much screening as women

  P Armaroli, F Gallo, A Bellomi, S Ciatto, D Consonni, D Davi, P Giorgi-Rossi, A Iossa, E Mancini, C Naldoni, E Polla, G Ronco
  [show abstract] [hide abstract]
  ABSTRACT: To assess the adequacy of a routine screening to identify cervical intraepithelial neoplasia 2 or worse (CIN2+) in women over 50 years of age, a retrospective cohort was set in six Italian organised population-based screening programmes. In all, 287 330 women (1 714 550 person-years of observation, 1110 cases) screened at age 25–64, with at least two cytological screening tests, the first negative, were followed from their first negative smear until a biopsy proven CIN2+ lesion or their last negative smear. For women aged 25–49 and 50–64 years, crude and age-standardised detection rate (DR), cumulative risk (CR), adjusted hazard risk for number of previous negative screens, probability of false-positive CIN2+ after two or more smear tests were calculated. Detection rate is significantly lower over 50 years of age. Multivariable analysis shows a significant protective effect from four screening episodes (DR=0.70, 95% CI: 0.51–0.97); the effect of age ⩾50 is 0.29 (95% CI: 0.24–0.35). The CR of CIN2+ is at least eightfold higher in women
  British Journal of Cancer - BRIT J CANCER. 01/2008; 99(2):239-244.