Michael Sturniolo

Publications (2)6.98 Total impact

• Article: TIG3: a regulator of type I transglutaminase activity in epidermis.

  Richard L Eckert, Michael T Sturniolo, Ralph Jans, Catherine A Kraft, Haibing Jiang, Ellen A Rorke
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  ABSTRACT: Keratinocytes undergo a process of terminal cell differentiation that results in the construction of a multilayered epithelium designed to produce a structure that functions to protect the body from dehydration, abrasion and infection. These protective properties are due to the production of a crosslinked layer of protein called the cornified envelope. Type I transglutaminase (TG1), an enzyme that catalyzes the formation of epsilon-(gamma-glutamyl)lysine bonds, is the key protein responsible for generation of the crosslinks. The mechanisms that lead to activation of transglutaminase during terminal differentiation are not well understood. We have identified a protein that interacts with TG1 and regulates its activity. This protein, tazarotene-induced gene 3 (TIG3), is expressed in the differentiated layers of the epidermis and its expression is associated with transglutaminase activation and cornified envelope formation. We describe a novel mechanism whereby TIG3 regulates TG1 activity.
  Amino Acids 08/2008; 36(4):739-46. · 3.25 Impact Factor
• Article: Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase.

  Richard L Eckert, Tatiana Efimova, Shervin R Dashti, Sivaprakasam Balasubramanian, Anne Deucher, James F Crish, Michael Sturniolo, Frederic Bone
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  ABSTRACT: The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.
  Journal of Investigative Dermatology Symposium Proceedings 01/2003; 7(1):36-40. · 3.73 Impact Factor