Yuan-Yuan Zhang

Publications (2)0 Total impact

• Article: [Quality control of non-alkaloids from Radix Sophorae tonkinensis].

  Yuan-Yuan Zhang, Zhi-Yong Guo, Guo-Xiang Xie, Yue-Qiu Gao, Ai-Hua Zhao, Wei Jia
  [show abstract] [hide abstract]
  ABSTRACT: To establish a method for quality control of non-alkaloids from Radix Sophorae tonkinensis. Sugar, organic-acid, polyphenolic and saponin were identified by TLC. The contents of Sugar, polyphenolic and saponin were determined by spectrophotometry and the content of organic-acids was determined by acid-based titration. The contents of sugar, polyphenolic and saponin were 54.37%, 4.74%, 4.40%, respectively. The average content of organic-acid was 9.40%. The established method is simple, accurate, reproducible and suitable for the quality control of non-alkaloids from Radix Sophorae tonkinensis.
  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 12/2008; 31(11):1730-4.
• Article: [Analysis of matrine and oxymatrine in Kushensu injection by UPLC/Q-TOF-MS].

  Mao Ye, Guo-xiang Xie, Ai-hua Zhao, Yuan-yuan Zhang, Wei Jia
  [show abstract] [hide abstract]
  ABSTRACT: To develop a method for the determination of matrine and oxymatrine in Kushensu injection by ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS). The analysis was performed on a Acquity UPLC BEH C18 column (2.1 mm x 100 mm, 1.7 microm) with the gradient elution of 10 mmol x L(-1) amine acetate (pH 8, adjusted by aqueous ammonia) and methanol. The flow rate was set as 0.30 mL x min(-1). The column temperature was maintained at 30 degrees C. The peaks were detected at 210 nm and the injection volume was 2 microL. The calibration curves showed good linearity within the test ranges of 0.084-3.36 microg for matrine and 0.086-3.44 microg for oxymatrine, respectively. The mean recoveries were 103.2%, 98.7%, and the RSD were 1.5%, 1.2%, respectively. The established method is simple, rapid and sensitive, can be used for the quality control of matrine and oxymatrine in Kushensu injection through the manufacturing process and clinical implement.
  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 07/2008; 33(12):1398-401.