Kyung Han

Publications (3)7.54 Total impact

• Article: Cytogenetic analysis in childhood acute lymphoblastic leukemia: experience at a single institution in Korea.

  Young Joo Kwon, Jae Wook Lee, Myung Shin Kim, Pil Sang Jang, Nak Gyun Chung, Dae Chul Jeong, Yong Goo Kim, Kyung Ja Han, Soon Ju Lee, Bin Cho, Hack Ki Kim
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  ABSTRACT: We evaluated major cytogenetic abnormalities associated with childhood acute lymphoblastic leukemia (ALL) through both fluorescent in situ hybridization and conventional chromosomal analysis for 132 ALL patients diagnosed at St Mary's Hospital in Korea. Chromosome abnormalities have been detected in 92% of patients. Eighteen (14%) patients showed numerical abnormalities only, 50 (38%) patients showed structural abnormalities only, and 53 (40%) patients showed both. The simultaneous trisomies 4, 10 and 17 were observed in 23 (17%) patients. Of the patients with abnormal karyotypes, recurrent structural abnormalities were determined in 103 (78%) cases. t(12;21)(q13;q22) was found in 29 (22%) out of 132 patients, 9p abnormalities in 13 (10%) patients, t(1;19)(q23;p13.3) in 11 (8%) patients, t(9;22)(q34;q11.2) in 11 (8%) patients, and 11q23 abnormalities in 7 (5%) patients. Interestingly, we identified five uncommon translocations such as t(5;12) (q33;p13), t(14;19)(q32;q13.1), t(12;16)(p13;q13), der(1)t(1;12)(p32;p13), and t(5;15)(p15;q11.2). Our study pool is representative of pediatric ALL patients in Korea as it consists of about 20% of patients diagnosed annually in Korea. We believe that the data provided will aid in comparative studies of the treatment outcomes, as well as the type and incidence of chromosomal abnormalities associated with childhood ALL in various Asian nations and Western countries.
  International journal of hematology 01/2009; 89(2):150-8. · 1.17 Impact Factor
• Article: Feasibility of single-stage laparoscopic resection after placement of a self-expandable metallic stent for obstructive left colorectal cancer.

  Tae-Sung Chung, Seok-Byung Lim, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han, Hyo Seong Choi, Seung-Yong Jeong
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  ABSTRACT: The present study investigated the feasibility of a single-stage operation consisting of self-expandable metallic stent (SEMS) placement followed by laparoscopic surgery for obstructive left colorectal cancer. From July 2002 to March 2007, 17 consecutive patients with primary obstructive left colorectal cancer underwent SEMS placement followed by laparoscopic surgery. Data were collected retrospectively regarding clinicopathological findings, SEMS placement, operative procedures, and perioperative outcomes. Technical success was defined as successful stent deployment across the obstructive lesion, and clinical success as the possibility of performing a single-stage operation without creating a stoma. In the laparoscopic group, the technical success rate was 100% (17/17) and there was no morbidity associated with SEMS placement. The median interval to laparoscopic surgery was 7 (range, 2-11) days, and the procedures included 11 anterior resections, 3 left hemicolectomies, 2 Hartmann's procedures, and 1 subtotal colectomy. All procedures were completed laparoscopically without conversion to open surgery. The median operating time was 178 (range, 93-377) minutes, and the median estimated blood loss was 100 (range, 50-400) ml with no cases requiring intraoperative transfusions. The clinical success rate was 82.4% (14/17), and there was no surgical morbidity other than two patients in whom chyloperitoneum and ileus were controlled by using conservative management. The median postoperative hospital stay was 9 (range, 7-49) days. A single-stage operation consisting of SEMS placement followed by laparoscopic surgery seems to be a feasible and safe treatment option for obstructive left colorectal cancer.
  World Journal of Surgery 11/2008; 32(10):2275-80. · 2.36 Impact Factor
• Article: Atypical endoscopic features can be associated with metastasis in rectal carcinoid tumors.

  Byung Nyun Kim, Dae Kyung Sohn, Chang Won Hong, Kyung Su Han, Hee Jin Chang, Kyung Hae Jung, Seok-Byung Lim, Hyo Seong Choi, Seung-Yong Jeong, Jae-Gahb Park
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  ABSTRACT: Endoscopically, rectal carcinoids have a variety of sizes and features which may assist in determining treatment plans. The present study was performed to assess the relationship between endoscopic features and metastasis in rectal carcinoids. A total of 115 rectal carcinoids of 112 patients with rectal carcinoids were enrolled, and the medical records were retrospectively reviewed. All tumors were classified according to size (longest diameter), and then according to endoscopic features such as shape, color, and surface changes including depressions, erosion, and ulceration. The relationship between endoscopic features and metastasis was evaluated. 11 cases (9.6%) of the 115 rectal carcinoids presented with metastatic disease. Tumor size was associated with metastasis (p < 0.001). Endoscopic features associated with metastasis were tumor shape, surface change, and color (p < 0.001). Atypical endoscopic features occurred more frequently as the size of the tumor increased (p < 0.001). For tumors 10-19 mm in diameter, atypical surface change was associated with metastasis (p = 0.007). Endoscopic features were found to be associated with metastasis in rectal carcinoids. In particular, atypical surface change may be useful in determining treatment plans for tumors 10-19 mm in diameter.
  Surgical Endoscopy 07/2008; 22(9):1992-6. · 4.01 Impact Factor