Shuming Ye

Zhejiang University, Hang-hsien, Zhejiang Sheng, China

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Publications (22)18.43 Total impact

  • Mengxing Liu, Shuming Ye, Zhi Xu, Hang Chen
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    ABSTRACT: Around the features of low power and high integration of portable electronic medical equipment design, the primary low power MCU series from the current semiconductor manufacturers were compared. The analysis results showed that the 32-bit MCUs based on the low cost and high energy efficient ARM Cortex-M architectures, have comprehensive advantages on power level, operational performance and integrated peripherals obviously.
    05/2014; 38(3):202-6.
  • Luyan Wang, Hang Chen, Shuming Ye
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    ABSTRACT: In order to achieve the simultaneous monitoring of multiple physiological signals and finish the real-time storage and transmission of data, this paper presents a multi-parameter physiological signal monitoring system based on Cortex-M3. The system uses high-capacity SD card for data storage and USB for data transmission, which achieves synchronous storage and display. In addition, it reduces the operating frequency to achieve the goal of low power consumption .The experimental results show that the system is characterized by high-capacity, low-power and high accuracy, which meets the user's requirements for physiological signal monitoring.
    2014 IEEE Workshop on Electronics, Computer and Applications (IWECA); 05/2014
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    ABSTRACT: A highly sensitive in-situ turbidity sensor with the low power consumption was proposed and evaluated in this study. To meet the practical requirements of the in-situ detection, we have designed the light scattering path, watertight mechanical structure, and ultra-weak scattering light detecting method. Experiments showed that the sensor had a sensitivity of 0.0076 FTU with the concentration range of 0–25 FTU and the R-square of 0.9999. The sensor could withstand the water pressure in depth of 1000 m and had the low power consumption in the active mode 10.4 mA, sleep mode 65 μA with a supply voltage of 8.4 V. Southern China Sea buoy experiments indicated that the sensor could work well in the actual in-situ environment. In comparison with sensors of other companies, our sensor had relatively more comprehensive performance.
    Photonic Sensors. 03/2014; 4(1).
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    ABSTRACT: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy. Nanosecond pulsed electric field (nsPEF) is a new technology destroying tumor cells with a non-thermal high voltage electric field using ultra-short pulses. The study's aim was to evaluate the ablation efficacy of nsPEFs with human HCC cell lines and a highly metastatic potential HCC xenograft model on BALB/c nude mice. The in vivo study showed nsPEFs induced HCC cell death in a dose dependent manner. On the high metastatic hepatocellular carcinoma cell line (HCCLM3) xenograft mice model, tumor growth was inhibited significantly in nsPEF-treated- groups (single dose and multi-fractionated dose). Besides a local effect, the nsPEF treatment reduced pulmonary metastases. The nsPEFs also enhanced HCC cell phagocytosis by human macrophage cell (THP1) in vitro. The nsPEF is efficient in controlling HCC progression and reducing its metastasis. NsPEF treatment may elicit a host immune response against tumor cells. This study suggests nsPEF therapy could be used as a potential locoregional therapy for hepatocellular carcinoma.
    Cancer letters 01/2014; · 5.02 Impact Factor
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    ABSTRACT: Recurrence and metastasis are associated with poor prognosis in hepatocellular carcinoma even in the patients who have undergone radical resection. Therefore, effective treatment is urgently needed for improvement of patients' survival. Previously, we reported that nanosecond pulse electric fields (nsPEFs) can ablate melanoma by induction of apoptosis and inhibition of angiogenesis. This study aims to investigate the in vivo ablation strategy by comparing the dose effect of nanosecond electric fields in vitro and in vivo on hepatocellular carcinoma. Four hepatocellular carcinoma cell lines HepG2, SMMC7721, Hep1-6, and HCCLM3 were pulsed to test the anti-proliferation and anti-migration ability of 100 ns nsPEFs in vitro. The animal model of human subdermal xenograft HCCLM3 cells into BALB/c nude mouse was used to test the anti-tumor growth and macrophage infiltration in vivo. In vitro assays showed anti-tumor effect of nsPEFs is dose-dependant. But the in vivo study showed the strategy of low dose and multiple treatments is superior to high dose single treatment. The macrophages infiltration significantly increased in the tumors which were treated by multiple low dose nsPEFs. The low dose multiple nsPEFs application is more efficient than high dose single treatment in inhibiting the tumor volume in vivo, which is quite different from the dose-effect relationship in vitro. Beside the electric field strength, the macrophage involvement must be considered to account for effect variability and toxicology in vivo.
    PLoS ONE 01/2014; 9(1):e86421. · 3.53 Impact Factor
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    ABSTRACT: The diagnosis of sleep apnea syndrome (SAS) has a significant importance in clinic for preventing diseases of hypertention, coronary heart disease, arrhythmia and cerebrovascular disorder, etc. This study presents a novel method for SAS detection based on single-channel electrocardiogram (ECG) signal. The method preprocessed ECG and detected QRS waves to get RR signal and ECG-derived respiratory (EDR) signal. Then 40 time- and spectral-domain features were extracted to normalize the signals. After that support vector machine (SVM) was used to classify the signals as "apnea" or "normal". Finally, the performance of the method was evaluated by the MIT-BIH Apnea-ECG database, and an accuracy of 95% in train sets and an accuracy of 88% in test sets were achieved.
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 10/2013; 30(5):999-1002.
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    ABSTRACT: A highly sensitive and reliable chlorophyll sensor is proposed and evaluated to meet the demand of in-situ chlorophyll detection. As the major innovation, pseudo-random sequence modulation is introduced into the amplitude measurement of the fluorescence for the first time. Compared with the conventional single frequency square wave modulation, the pseudo-random sequence modulation could spread the spectrum of the fluorescence, and improve the sensitivity and the interference suppression ability of the sensor without increasing the complexity of the system's hardware. The sensitivity experiments show that the sensor could detect chlorophyll as low as 0.0103 μg/L, with the concentration range of 0~25 μg/L and the R-square of 0.9998. In the interference suppression test, for the same interference in the passing band, the maximum response of the 31 bits PRS modulation system is 2.3 times smaller than that of the single frequency square wave modulation system.
    IEEE Transactions on Instrumentation and Measurement 01/2013; 62(8):2314-2322. · 1.71 Impact Factor
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    ABSTRACT: This paper presents a novel method for automatic identification of motion artifact beats in ECG recordings. The proposed method is based on the ECG complexes clustering, fuzzy logic and multi-parameters decision. Firstly, eight simulated datasets with different signal-to-noise ratio (SNR) were built for identification experiments. Results show that the identification sensitivity of our method is sensitive to SNR levels and acts like a low-pass filter that matches the cardiologists' recognition, while the Norm FP rate and PVB FP rate keep significantly low regardless of SNR. Furthermore, a simulated dataset including random durations of motion activities superimposed segments and two clinical datasets acquired from two different commercial recorders were adopted for the evaluation of accuracy and robustness. The overall identification results on these datasets were: sensitivity >94.69%, Norm FP rate <0.60% and PVB FP rate <2.65%. All the results were obtained without any manual threshold adjustment according to the priori information, thus dissolving the drawbacks of previous published methods. Additionally, the total cost time of our method applied to 24 h recordings is less than 1 s, which is extremely suitable in the situation of magnanimity data in long-term ECG recordings.
    Annals of Biomedical Engineering 03/2012; 40(9):1917-28. · 3.23 Impact Factor
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    ABSTRACT: As one of the major propulsion plants of marine system, the controllable pitch propeller (CPP) has been widely applied in dynamic systems of a variety of ships at present. Both the operations on CPP from crew and the CPP's actual working state are closely related to safe and successful navigations. Aiming at this fact, a novel data logger based on embedded platform and field bus was designed and developed, which can meet the requirements of long-playing, online, continuous collecting and recording the information of operator's commands on CPP and CPP's working state with the actual time. These data that could be read and analyzed by authorized staff when necessary can provide convincing evidence for accident analysis and equipment maintenance. A practical data cache technology and power-down data integrity protection mechanism are also mentioned in this article. The test results indicated that this data logger, which can work continuously for more than 50 days in general case if the operator does not want any data to be overwritten, has high reliability and great practical value.
    01/2012;
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    ABSTRACT: A multi-parameter monitoring system mainly includes invasive blood pressure, PPG and electrocardiogram was designed. We analyzed these signals and extracted some parameters from them, such as SpO2, PPGA, RC, AR, Ps, Pd, Pm, IBPA, IBPI, R and C, which are provided as bases for judgment of doctors. A validation clinical experiment was analyzed, and the results confirmed that the system realized the monitoring of cardiovascular parameters during anesthesia.
    Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on; 01/2012
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    ABSTRACT: A wireless implantable sensor network system (WISNS) is designed for in vivo monitoring physiological signals of a population of animals. WISNS can simultaneously monitor more than 15 animals, communicating three kinds of analog information among sensor nodes. Analog signals are transmitted to relay node at 800-KHz carrier by AM. Relay nodes digitalize and package them into messages, and then forward to the Wireless sensor network by Nordic RF technology (NWSN). Smaller overall dimensions (<2 cm (3)), lower power regulation, and dedicated packaging make the system suitable and compatible for implantable devices. The implantable sensor node, protocol stack of NWSN, and performance of the system are evaluated and optimized with ECG monitoring test of rats. Compared with those commercially available sensor nodes, our implantable one is leading in the weight and volume miniaturization, and our WISNS solution shows huge potential in achieving the compatibility of different animals.
    IEEE transactions on information technology in biomedicine: a publication of the IEEE Engineering in Medicine and Biology Society 05/2011; 15(4):577-84. · 1.69 Impact Factor
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    ABSTRACT: Automatic detection of atrial fibrillation (AF) for AF diagnosis, especially for AF monitoring, is necessarily desirable for clinical therapy. In this study, we proposed a novel method for detection of the transition between AF and sinus rhythm based on RR intervals. First, we obtained the delta RR interval distri bution difference curve from the density histogram of delta RR intervals, and then detected its peaks, which represented the AF events. Once an AF event was detected, four successive steps were used to classify its type, and thus, determine the boundary of AF: 1) histogram analysis; 2) standard deviation analysis; 3) numbering aberrant rhythms recognition; and 4) Kolmogorov-Smirnov (K-S) test. A dataset of 24-h Holter ECG recordings (n = 433) and two MIT-BIH databases (MIT-BIH AF database and MIT-BIH nor mal sinus rhythm (NSR) database) were used for development and evaluation. Using the receiver operating characteristic curves for determining the threshold of the K-S test, we have achieved the highest performance of sensitivity and specificity (SP) (96.1% and 98.1%, respectively) for the MIT-BIH AF database, compared with other previously published algorithms. The SP was 97.9% for the MIT-BIH NSR database.
    IEEE Transactions on Biomedical Engineering 05/2011; · 2.35 Impact Factor
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    ABSTRACT: Photoplethysmogram (PPG) of pulse wave has been proposed for analgesia monitoring recently with most attentions paid to its magnitude and little attention to its morphology. Therefore, effect of nociceptive stimuli on the morphology of PPG was studied using a morphological parameter named area ratio (AR). Fifty patients, ASA I or II, scheduled for laparoscopy surgery under general anaesthesia were enrolled. They were anaesthetized using propofol and remifentanil, and their PPG signals were recorded. Tracheal intubation was used as a nociceptive stimulus. Off-line analysis showed that the morphology of PPG was influenced by the intubation. The AR increased during intubation and returned to the initial level. Its distributions before intubation (0.687±0.153) and during intubation (0.862± 0.125) were very highly significantly different (P
    01/2011;
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    ABSTRACT: Photoplethysmography (PPG) is an effective technique that can be used to detect blood volume changes in the microvascular bed of tissue. However, when the patients are in poor perfusion, the signal of PPG will be too weak to detect. So a dynamic variable amount of light detection method is designed to solve the problem. The method adjusts the hardware and software of original method. By using this method, the detector can detect the waveform of PPG more effectively, and greatly improve the accuracy of measurement. It has been used in clinical studies of surgical anesthesia, and achieved very good results.
    01/2011;
  • IEEE Transactions on Information Technology in Biomedicine. 01/2011; 15:577-584.
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    ABSTRACT: An optical cell system was developed for online research into the luminescence spectrum under conditions of extremely high hydrostatic pressure up to 60 MPa. The optical cell, which had three 8 mm thick sapphire windows 16 mm in diameter, was mounted directly onto a fluorescence spectrometer. Hydrostatic pressure was achieved through a hand pump and monitored through a pressure sensor. The optical cell system could be used separately. And more importantly, the system could be connected to a high-pressure flowing system for online flowing luminescence measurement. For system validation, fluorescence spectra of Rose Bengal solution using the high-pressure cell were compared with the standard sample holder. Using the system, fluorescence spectra of Rose Bengal dissolved in distilled water were measured under different pressures at room temperature. The fluorescence intensity of Rose Bengal solution changed with pressures, but the peak positions were almost the same.
    High Pressure Research 01/2010; 30(1):190-197. · 0.90 Impact Factor
  • Chen He, Hang Chen, Shuming Ye
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    ABSTRACT: T-wave alternans (TWA) in electrocardiogram (ECG) is associated with an increasing propensity to ventricular arrhythmic and is regarded as an independent indicator of sudden cardiac death (SCD). Various methods have been proposed to detect and quantify TWA in recent years, however, less attention was paid on the pretreatment stage before the final decision step. A detector with spectral method (SM) using multi-pretreatment was designed to detect TWA in this paper. It was tested with ECGs in the PhysioNet database, and the testing results showed that this improved system was effective to obtain enhanced detection results in comparison of ordinary methods in three aspects.
    01/2010;
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    ABSTRACT: An advanced control system used in assisted circulation apparatus of artificial liver support system was developed based on embedded platform and field bus. This system consisted of a cardiopulmonary bypass-controlling system, a blood circulation and reactors status-monitoring system, and a human-machine interface and communication system. Multiple functions are implemented such as on-line monitoring, controlling and driving of the assisted circulation apparatus, real-time supervising and regulating of the physiological environments in reactors, and convenient, rapid operation mode, with high security, stability and practicality. The implementation of this system is helpful to the independent construction and evaluation of artificial liver support system, as well as the research works on hepatocyte culture and bioreactor design.
    Proceedings of the 2nd International Conference on BioMedical Engineering and Informatics, BMEI 2009, October 17-19, 2009, Tianjin, China; 01/2009
  • Kai Jiang, Shuming Ye, Hang Chen, Fei Gu
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    ABSTRACT: In this paper, a new index called grouped weighted coding was proposed for protein structural class prediction. The component coupled algorithm was adopted to compare the new index with other two traditional indices. We used the resubstitution and jack-knife test for evaluation. The result showed that the new index was 5-7% higher than the amino acid composition index and was 1-3% higher than the auto-correlation function index. The advantage of efficiency, biological significance and high accuracy made grouped weighted coding index more useful in protein structural class prediction.
    Bioinformatics and Biomedical Engineering, 2008. ICBBE 2008. The 2nd International Conference on; 06/2008
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    ABSTRACT: New target controlled infusion (TCI) for propofol using a hybrid physiologically based pharmacokinetic (PBPK) model was proposed in this paper. The hybrid model was composed of a three-compartment mamillary systemic model and a two-compartment brain model. A closed-loop control algorithm with brain concentration as the control variable was used to calculate the infusion. Finally, the dose regimen was applied in clinical practice and the recorded auditory evoked potentials showed good depth of anaesthesia. The TCI was feasible and had potential applications.
    01/2008;