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Urology journal 01/2013; 10(1):815-7. · 0.58 Impact Factor
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ABSTRACT: To evaluate the clinical results of tube gastrostomy in radical cystectomy and ileal conduit.
We retrospectively analyzed the data of 98 patients undergoing radical cystectomy and ileal conduit between March 2007 and February 2010. According to postoperative gastrointestinal decompression methods, the patients were divided into nasogastric decompression group (n=50) and tube gastrostomy group (n=48), and the gastrointestinal recovery time, surgical complications and hospital stay were compared between them.
No statistical difference was found in gastrointestinal recovery time, hospital stay, or surgical complications between the two groups, but the incidence of pulmonary infection was significantly lower in tube gastrostomy group than in nasogastric decompression group (P<0.05).
Tube gastrostomy is an easy, safe and effective means for gastric decompression after radical cystectomy with ileal conduit, especially suitable for elderly patients and those with potential pulmonary disorder.
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 08/2012; 32(8):1194-6.
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ABSTRACT: Objective: To compare the outcome of mini-tract vs standard-tract percutaneous nephrolithotomy (PCNL) in staghorn calculi. Methods: Between May 2009 and May 2011, 122 patients with renal staghorn calculi were treated by PCNL. Fifty-six patients underwent mini-PCNL and the others underwent standard-PCNL. The therapeutic effect and complication of the 2 groups were compared. Results: The two groups had comparable demographic conditions. Although the operation time was significantly longer in mini-PCNL group [(126±24.5) min vs (98±18.9) min], there was no striking difference in hospital stay [(5.7±1.3) d vs (5.3±1.1) d], hemoglobin drop [(9.5±3.2) g/L vs (10.5±3.3) g/L], stone-free state before charge (91.1% vs 89.4%) and complications. Conclusion: The efficacy and safety of mini-PCNL and standard-PCNL are not significantly different.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 08/2012; 37(8):840-3.
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ABSTRACT: Primary testicular non-Hodgkin's lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkin's lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappropriate and dysregulated activation of the immune system. We report a 47-year-old man with primary TNHL who developed HPS four months after occurrence of scrotal swelling. To the best of our knowledge, primary TNHL associated with HPS has not previously been reported.
Oncology letters 07/2012; 4(1):59-62. · 0.11 Impact Factor
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ABSTRACT: To demonstrate the safety and efficacy of flexible ureteroscopy (FURS) and holmium laser lithotripsy as a valuable treatment of bilateral multiple intrarenal stones and stratify the efficacy by stone burdens ≤20 and >20 mm.
Twenty-five patients with bilateral multiple intrarenal stones were treated with FURS and holmium lithotripsy at a single clinic. The operative time, stone-free rates (SFRs) per renal unit, stone compositions, number of procedures, serum creatinine, and complications were evaluated. The SFRs were evaluated with computed tomography and plain X-rays of the kidneys, ureters, and bladder. Renal ultrasound was performed 30 days after double-J stent removal to identify hydronephrosis and absence of stones. We defined a stone-free status as the absence of fragments in the kidney or fragments of <1 mm.
The total stone number was 128 with a mean stone burden per patient of 24 ± 5 (range 17-37 mm). The overall SFRs per renal unit after 1, 2, and 3 procedures were 70.0%, 92.0%, and 92.0%, respectively. The overall SFRs per renal unit for patients with a preoperative stone burden ≤20 and >20 mm were 100% and 85.7%, respectively. No major intraoperative or postoperative complications occurred. There were only 4 minor postoperative complications (16%).
Our study results firmly suggest that FURS with holmium laser lithotripsy represents a favorable alternative to external shock wave lithotripsy or percutaneous nephrolithotomy for select patients with bilateral multiple intrarenal stones, which have a satisfactory efficacy and low morbidity.
Urology 06/2012; 80(4):800-4. · 2.43 Impact Factor
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ABSTRACT: To analyze efficacy and safety of percutaneous nephrolithotomy (PCNL) in the management of staghorn calculi with solitary kidney.
Between April 2009 and December 2011, 13 patients with renal staghorn calculi in solitary kidney were treated by PCNL in our hospital. The therapeutic effects and complications were the main points of the analysis.
Of the 13 patients, surgery time was 92-164 (117.2±21.5) min; 9 cases underwent PCNL through a single access tract, 4 cases through multi-access tracts. The stone removal rate in one session of PCNL was 76.9%, and the total clearance rate was 92.3%. Hemoglobin dropped 11-32 (16.4±4.6) g/L; one case required blood transfusion; no patient had embolism. Hospital stay was 5-10 (6.9±1.5) days postoperatively. Serum creatinine before PCNL in these patients was 83-237 (146.24±38.73) μmol/L compared to 81-242 (134.56±21.52) μmol/L by the end of the 1-month follow-up period (not statistically different). Similar findings were observed in glomerular filtration rates: before PCNL it was 42-114 (71.32±20.82) mL/min and by the end of the 1-month follow-up it was 55-117 (79.40±22.14) mL/min (not statistically different).
PCNL is effective and safe for the treatment of staghorn stones in solitary kidney, and has advantages such as short surgical duration, fewer complications, rapid recovery, short hospital stay, effective stone removal rate, and so on.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 06/2012; 37(6):621-4.
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ABSTRACT: Sedum sarmentosum bunge (SSB)., S. lineare Thunb. (SLT), S. erythrostictum migo. (SEM), and S. aizoon L. (SAL) were four widely used Chinese traditional drugs or ethnic drugs, which were easy to be confused with each other.
This study aimed at developing a rapid and accurate method to identify the four Sedum plant medicines with very similar appearances and close relationships.
The herbal medicines employed here were SSB, SLT, SEM, and SAL collected in different places and seasons. Through comparing the infrared (IR) spectra of their 70% ethanol extracts, the results showed that the IR spectra of the four plant medicines possessed not only some common characteristics but also certain notable distinctions, such as shapes, numbers, positions, intensity, and ratios of the absorbing peaks.
By fourier transform infrared (FT-IR) spectroscopy, the four medicines could be effectively differed, their habitats could be judged preliminarily, and the genetic relationships of the original plants of the four medicines could also be estimated to some extent.
The application of FT-IR spectroscopy in crude medicine authentication and quality evaluation deserved to be further emphasized.
Pharmacognosy Magazine 04/2012; 8(30):107-10. · 1.16 Impact Factor
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ABSTRACT: The X-ray repair cross-complementing group 3 (XRCC3), one of the DNA repair genes, was suggested to play an imperative role in the development of carcinogenesis. The objective of this study was to evaluate the role of the XRCC3 T241M polymorphism in bladder cancer susceptibility in a Chinese population. We genotyped 150 bladder cancer cases and 150 healthy controls who had been frequency matched to cases by age and sex. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. A significant association was found between smoker and bladder cancer [odds ratio (OR)=1.97, 95% confidence interval (CI)=1.24-3.13, p=0.004]. The XRCC3 241MM genotype was more frequent in the bladder cancer group than in the healthy controls group (OR=3.22, 95% CI=1.14-9.11, p=0.03). There were no significant associations between any genotypes and the stage, grade, and histological type of bladder cancer. Our study suggested an increased risk role of XRCC3 241MM genotype in bladder cancer susceptibility in a Chinese population.
Genetic Testing and Molecular Biomarkers 02/2012; 16(6):640-3. · 1.11 Impact Factor
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ABSTRACT: To determine the relationship between comorbidity and outcome after radical cystectomy in Chinese patients by using the Adult Comorbidity Evaluation (ACE)-27 index. Two-hundred-and-forty-six patients treated with radical cystectomy at the Second Xiangya Hospital of Central South University, Hunan Province, China between 2000 and 2010 were retrospectively analyzed. Medical records were reviewed for age, gender, delayed time of radical cystectomy, urinary diversion type, pelvic lymphadenectomy status, TNM stage, and pathological grade. Comorbidity information was assessed by the ACE-27 index. The outcome measurement was overall survival. Univariate and multivariate Cox proportional hazards regression analyses were used to determine the association between comorbidity and outcome. The study population consisted of 215 (87.40%) males and 31 (12.60%) females with a mean age of 62±11 years. Median duration of follow-up was 47±31 months. A total of 151 (61.38%) patents died during follow-up. Of those, 118 (47.97%) had at least one comorbidity. According to the ACE-27 scores, 128 (52.03%) patients had no comorbidity, 79 (32.11%) had mild, 33 (13.41%) had moderate, and 6 (2.45%) had severe comorbidities. Multivariate analysis indicated that moderate (p=0.002) and severe (p<0.001) comorbidity was significantly associated with decreased overall survival. In addition, age ≥70 years (p=0.002), delayed time of radical cystectomy >12 weeks (p=0.044), pelvic lymphadenectomy status (p=0.014), and TNM stage >T3 (p<0.001) were determined to be independent risk factors of overall survival. Increasing severity of comorbidity statistically correlated with decreased overall survival after radical cystectomy.
Asian Pacific journal of cancer prevention: APJCP 01/2012; 13(3):827-31. · 0.66 Impact Factor
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ABSTRACT: It was the aim of this study to explore the effects of 3-(5'-hydroxymethyl-2'-furyl)-l-benzyl indazole (YC-1) on transcription activity, cell proliferation and apoptosis of hypoxic human bladder transitional carcinoma cells (BTCC), mediated by hypoxia-inducible factor 1α (HIF-1α).
BTCC cell line T24 cells were incubated under normoxic or hypoxic conditions, adding different doses of YC-1. The protein expression of HIF-1α and HIF-1α-mediated genes was detected by Western blotting. RT-PCR was used to detect HIF-1α mRNA expression. Cell proliferation, apoptosis and migration activity were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and transwell migration assay. The cells were pretreated by two ERK/p38 MAPK pathway-specific inhibitors, PD98059 or SB203580, and then incubated with YC-1 treatment under hypoxic condition. HIF-1α protein expression was detected by Western blotting.
Hypoxic T24 cells expressed a higher level of HIF-1α, vascular endothelial growth factor, matrix metalloproteinases-2, B-cell lymphoma/leukemia-2 protein and HIF-1α mRNA compared with normoxic controls, in which the above-mentioned expression was downregulated by YC-1 in a dose-dependent manner. Cell proliferation and migration activity were inhibited while apoptosis was induced by YC-1 under hypoxic condition. Moreover, YC-1-downregulated HIF-1α expression was reversed by PD98059 and SB203580, respectively.
YC-1 inhibits HIF-1α and HIF-1α-mediated gene expression, cell proliferation and migration activity and induces apoptosis in hypoxic BTCC. The ERK/p38 MAPK pathway may be involved in YC-1-mediated inhibition of HIF-1α.
Urologia Internationalis 01/2012; 88(1):95-101. · 0.99 Impact Factor
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ABSTRACT: To report our experience with Chinese minimally invasive percutaneous nephrolithotomy (Chinese MPCNL) to manage patients with intrarenal stones in solitary kidney, and evaluate the safety, efficiency and feasibility of this technique.
Forty-one patients with intrarenal stones in solitary kidney underwent Chinese MPCNL in our department from March 2009 to February 2011. Demographic characteristics, operative parameters, number of tracts, stone-free rates (SFRs), stone analyses, hemoglobin levels, nephrostomy tube removal time, hospitalization time, and complications were evaluated. Serum creatinine (Scr) and glomerular filtration rate (GFR) were measured preoperatively, postoperatively at 1 month, and each follow-up visit. The 5-stage classification of chronic kidney disease (CKD) was used according to the National Kidney Foundation guidelines.
The initial stone-free status was achieved in 35 (85.4%) patients after Chinese MPCNL. The mean follow-up time was 16.9 ± 4.7 months (range: 12-24), and the final SFR improved to 97.6% after auxiliary procedures. Among all patients, complex stones were detected in 26 (63.4%) patients, and 9 (22.0%) required multiple tracts. The mean operative time and mean hospitalization time were 71.3 ± 23.5 min (range: 40-139) and 6.1 ± 0.5 days (range: 5-11), respectively. During preoperative period and postoperative period (1 month), Scr were 132.1 ± 41.3 umol/L (range: 78.2-231.4) and 108.9 ± 30.7 umol/L (range: 71.6-136.9), respectively (P<0.05), while GFR were 74.9 ± 24.2 ml/min (range: 35-110) and 83.9 ± 27.4 ml/min (range: 65-110), respectively (P<0.05). According to CKD classification, the renal function was stable, improved, and worse in 29 (70.7%), 11 (26.8%), and 1 (2.5%) patients, compared with the preoperative levels. No patient progressed to end-stage renal disease requiring dialysis.
Our experience with Chinese MPCNL demonstrates that it is safe, feasible and efficient for managing the intrarenal calculi in solitary kidney with a low complication rate. At long-term follow-up, renal function stabilized or even improved in the majority of patients with solitary kidney.
PLoS ONE 01/2012; 7(7):e40577. · 4.09 Impact Factor
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ABSTRACT: Non-muscle-invasive urothelial carcinoma of the bladder has a high rate of recurrence, necessitating use of a variety of adjuvant treatments. A single, immediate post-operative administration of chemotherapy is an important measure for reducing the rate of recurrences, but the overall effect is not satisfactory and the treatment is a burden to the patient. Hence, there is a need for a new, more effective and cheaper agent for adjuvant treatment of non-muscle-invasive bladder carcinomas. Although cationic surfactants such as benzalkonium salts are used clinically and hygienically for the control of bacterial growth, there have been reports that cationic surfactants such as benzethonium chloride induce apoptosis in normal and in cancerous cells. We report our experience with benzalkonium bromide (BB) accidentally administered into a patient's bladder as saline. It caused severe hematuria and pain, but after a week of persistent administration in the bladder, the patient was cured, as supported by evidence from cystoscopy, indicating that BB destroys bladder mucosa and suggesting that BB maybe a novel agent for use in a single, immediate post-operative administration. We present preliminary data to support this hypothesis and provide discussion we hope will be useful as the foundation for further experiments.
Medical science monitor: international medical journal of experimental and clinical research 12/2011; 17(12):HY36-9. · 1.70 Impact Factor
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ABSTRACT: Bowel preparation (BP) is performed routinely before intestinal surgery to reduce the risk of postoperative infectious complications. We studied the effect of BP on patients who underwent radical cystectomy and ileal conduit surgery. Our goal was to determine whether BP in these patients provided any benefits postoperatively.
Between Match 2006 and January 2009, 86 patients scheduled for radical cystectomy and ileal conduit were randomized to preoperative BP (group A) or surgery without BP (group B). Outcomes studied included operative time, recovery of patient and surgical complications.
Eighty-six patients were included in the study, 47 in group A and 39 in group B. All surgeries were performed successfully using ileum. Postoperative complications were documented in 5 and 6 patients in groups A and B, respectively. Anastomotic leak occurred in 1 patient in group A, leading to multiple organ dysfunction and sepsis, with a fatal outcome. One case of ileus and three wound infections were also seen in group A. In group B, wound infection and ileus occurred in two patients each, anastomotic leak developed in 1 patient resulting to reoperation and one patient died from pulmonary embolism. No statistical difference in the frequency of complications and recovery of patient was observed between the 2 groups.
Our results suggest that no advantage is gained by preoperative BP in radical cystectomy and ileal conduit.
International Urology and Nephrology 04/2010; 42(4):947-50. · 1.47 Impact Factor
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ABSTRACT: To study identification methods of Dai medicine" Guomaguo", the fruit of Spondias pinnata.
Characteristic, microscopic observation and TLC idertification were used to authenticate this crude drug.
The characters of the cross section, powder and TLC of the drug were reported, and the relevant drawings of the tissue, powder and TLC of this ethnomedicine were drawn.
These results can supply evidences for the identification of the ethnomedicine in its exploitation and utilization.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 02/2009; 32(1):39-41.
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ABSTRACT: To establish methods for identification of Dai medicine, the heartwoods and leaves of Cassia siamea.
Macroscopic, microscopic observation and TLC technique were used to anthenticate this crude drug, and the identification characteristics were studied.
Macroscopic and microscopic identification methods and TLC characters of the ethnomedicine were re-ported, and the simple and detailed drawings of the transections of the heartwoods and leaves, as well as microscopic drawings of their powders were drawn in this paper.
The results can serve as evidence for identification of the ethnomedicine in the utilization.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 08/2008; 31(7):974-7.
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ABSTRACT: To establish methods for identification of the whole plant of Sedum emarginatum Migo.
Macroscopic and microscopic observation and FTIR technique were used to authenticate this crude drug, and the identification characteristics were studied.
The stem cross section and the whole plant powder had some notable micro-characters. The infrared spectras of the samples collected in the different habitats and seasons were very consistent with each other.
The results can be used as the evidence for identification of this ethnomedicine.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 06/2008; 31(5):660-2.
