Publications (2)2.52 Total impact
Article: Development of common variable immunodeficiency in IgA- and IgG2-deficient patients with systemic lupus erythematosus.[show abstract] [hide abstract]
ABSTRACT: BACKGROUND: There have been few reports on children who developed common variable immunodeficiency (CVID) in association with immunoglobulin A (IgA) and IgG2 deficiencies and systemic lupus erythematosus (SLE). CASE-DIAGNOSIS/TREATMENT: Our patient experienced nephrotic syndrome and acute respiratory distress syndrome (ARDS) caused by influenza A/H1N1 virus infection at 5 years of age. A diagnosis of IgA and IgG2 deficiency and SLE was made on the basis of severe proteinuria, hematuria, hypocomplementemia, high anti-DNA antibody and antinuclear antibody (ANA) titers, and malar rash. However, these clinical signs and symptoms and laboratory features disappeared after the administration of methylprednisolone pulse therapy and prednisolone. For the 5 years following the initial treatment for SLE, the patient experienced a number of infections and had a low serum total IgG level; she was eventually diagnosed with CVID. The administration of intravenous immunoglobulin (IVIG) was required to prevent subsequent infections, and no relapse of SLE was observed. CONCLUSION: We report the development of CVID in an IgA- and IgG2-deficient patient with SLE on the basis of multiple episodes of infection. To prevent the development of CVID in IgA- and IgG2-deficient patients with SLE, it is important to prevent immune dysregulation by the avoidance of infections through the use of IVIG therapy.Pediatric Nephrology 12/2011; 27(3):489-92. · 2.52 Impact Factor
Article: [Epidemiological and virological study of aseptic meningitis in children caused by echovirus type 30 in Fukushima in 2004].[show abstract] [hide abstract]
ABSTRACT: An outbreak of aseptic meningitis caused by echovirus type 30 (E-30) occurred in the southern area of Fukushima Prefecture from March to September in 2004. The data of 54 patients with E-30 meningitis were analyzed. The median age was 7.3 years and the age range was 4 to 14 years. The male to female ratio was 2.2:1. The major symptoms of fever, headache and nausea/vomiting were observed more than 80% of the patients. The mean cerebrospinal fluid cell count was 104/microL, and polymorphonuclear cells were predominant in 61% of the cases. The clinical characteristics were not remarkably different from those in the outbreak in the middle to southern region of Fukushima Prefecture in 1997. The phylogenetic analysis based on the VP4 structural gene showed that the E-30 strains isolated in 2004 formed different clusters from those isolated during other time periods, suggesting that a variant genotype of E-30 was responsible for the outbreak in Fukushima in 2004.Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 06/2008; 82(3):177-81.