C Palm

Publications (4)6.26 Total impact

• Article: Liquorproteomanalyse bei klinisch isoliertem Syndrom und MS

  H. Tumani, D. Rau, V. Lehmensiek, I. Guttmann, G. Tauscher, C. Palm, V. Hirt, S.D. Süssmuth, J. Brettschneider
  Der Nervenarzt 05/2012; 80:30-31. · 0.68 Impact Factor
• Article: CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis.

  H Tumani, V Lehmensiek, D Rau, I Guttmann, G Tauscher, H Mogel, C Palm, V Hirt, S D Suessmuth, I Sapunova-Meier, A C Ludolph, J Brettschneider
  [show abstract] [hide abstract]
  ABSTRACT: Cerebrospinal fluid (CSF) is a promising source of biomarkers in clinically isolated syndrome (CIS), which frequently presents as a first episode of multiple sclerosis (MS). Using the two-dimensional difference in gel electrophoresis (2-D DIGE), we compared CSF samples from patients with CIS that remained CIS (CIS-CIS, n=8) over a follow-up time of 2 years and from patients with CIS that developed definite MS of the relapsing-remitting subtype (CIS-RRMS, n=8) over the same period. Protein spots that showed significant differences between patients and controls were selected for further analysis by MALDI-TOF mass spectrometry. For validation of identified spots ELISA experiments were performed. We identified one protein that was upregulated in CIS-RRMS (serin peptidase inhibitor) and eight proteins (alpha-1-B-glycoprotein, Fetuin-A, apolipoprotein A4, haptoglobin, human Zinc-alpha-2-glycoprotein (ZAG), Retinol-binding protein, superoxid dismutase 1, transferrin) that were down-regulated in CIS-RRMS vs. CIS-CIS. For Fetuin-A, our findings could be confirmed by ELISA. The pathophysiological role as well as clinical relevance of these candidate proteins in CIS remains to be further clarified by future studies.
  Neuroscience Letters 04/2009; 452(2):214-7. · 2.11 Impact Factor
• Article: Diagnosis of cerebral toxoplasmosis by detection of Toxoplasma gondii tachyzoites in cerebrospinal fluid.

  C Palm, H Tumani, T Pietzcker, D Bengel
  Journal of Neurology 05/2008; 255(6):939-41. · 3.47 Impact Factor
• Article: CSF proteome analysis in clinically isolated syndrome (CIS): Candidate markers for conversion to definite multiple sclerosis

  H. Tumani, V. Lehmensiek, D. Rau, I. Guttmann, G. Tauscher, H. Mogel, C. Palm, V. Hirt, S.D. Suessmuth, I. Sapunova-Meier, A.C. Ludolph, J. Brettschneider
  [show abstract] [hide abstract]
  ABSTRACT: Cerebrospinal fluid (CSF) is a promising source of biomarkers in clinically isolated syndrome (CIS), which frequently presents as a first episode of multiple sclerosis (MS). Using the two-dimensional difference in gel electrophoresis (2-D DIGE), we compared CSF samples from patients with CIS that remained CIS (CIS-CIS, n = 8) over a follow-up time of 2 years and from patients with CIS that developed definite MS of the relapsing-remitting subtype (CIS-RRMS, n = 8) over the same period. Protein spots that showed significant differences between patients and controls were selected for further analysis by MALDI-TOF mass spectrometry. For validation of identified spots ELISA experiments were performed. We identified one protein that was upregulated in CIS-RRMS (serin peptidase inhibitor) and eight proteins (alpha-1-B-glycoprotein, Fetuin-A, apolipoprotein A4, haptoglobin, human Zinc-alpha-2-glycoprotein (ZAG), Retinol-binding protein, superoxid dismutase 1, transferrin) that were down-regulated in CIS-RRMS vs. CIS-CIS. For Fetuin-A, our findings could be confirmed by ELISA. The pathophysiological role as well as clinical relevance of these candidate proteins in CIS remains to be further clarified by future studies.
  Neuroscience Letters.