P C Ng

The Chinese University of Hong Kong, Hong Kong, Hong Kong

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Publications (136)441 Total impact

  • HS Lam · HM Cheung · CLS Chau · PC Ng
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    ABSTRACT: Background and aim Decisions whether or not to perform high-risk surgery in preterm infants depend on prognosis and preferences/values of society as well as parents and healthcare workers. We aimed to assess differences in preferences between these groups to life-saving surgery in critically ill infants. Methods Paediatric doctors and nurses, parents of preterm infants (PPs) and term infants (PTs) were recruited. A scenario with a critically ill preterm infant with necrotising enterocolitis requiring surgery was presented. Surgery would result in gastrointestinal complications and one of five possible disability health-states (HS1 mild cognitive, severe physical; HS2 moderate respiratory; HS3 severe cognitive and mild physical; HS4 otherwise uncomplicated; HS5 moderate cognitive and mild respiratory complications). Without surgery, the infant would die. Subjects (i) ranked death and the health-states according to perceived severity and (ii) decided for each health-state whether or not to proceed with surgery “at all costs”. Results 55 doctors, 102 nurses, 178 PPs and 201 PTs were recruited. (i) Nurses more likely ranked states with predominant cognitive disability (HS3 and HS5) as worse than death compared with other groups. (ii) In less adverse health-states (HS1 and HS4) there were no differences between groups. Again, nurses were least likely to decide to save-at-all-costs in HS3 and HS5 and PPs were more likely to decide to save-at-all-costs than healthcare workers in a poor outcome (HS5). Conclusions Nurses were least tolerant to adverse health-states. We show that health state preferences vary between doctors, nurses and parents. Parental counselling should account for these differences.
    Archives of Disease in Childhood 10/2014; 99(Suppl 2):A460-A461. DOI:10.1136/archdischild-2014-307384.1274 · 2.90 Impact Factor
  • H. S. Lam · P. C. Ng
    Neonatology 01/2014; 106(3):278-279. · 2.65 Impact Factor
  • Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 12/2013; 19 Suppl 8:10-1. · 0.87 Impact Factor
  • Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 12/2013; 19 Suppl 8:12-5. · 0.87 Impact Factor
  • T F Leung · A M Li · G Wk Wong · S Ps Wong · C Wk Lam · P C Ng
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    ABSTRACT: 1. Prediction equations and normograms are established using incentive spirometry in a community cohort of 770 Hong Kong Chinese children aged 2 to 6 years. 2. All spirometric parameters depend mainly on standing height. Boys have higher values than girls. 3. Forced expiratory volumes depend on birth weight, place of birth, history of wheezing, and environmental tobacco smoke (ETS) exposure. 4. High urinary cotinine level as a biomarker of ETS exposure is noted in about one tenth of the children. 5. Urinary cotinine level is inversely associated with all spirometric parameters. This supports implementation of the smoking cessation programme.
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 12/2013; 19 Suppl 9:21-5. · 0.87 Impact Factor
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  • T F Leung · P K S Chan · G W K Wong · T F Fok · P C Ng
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    ABSTRACT: 1. Respiratory viruses and atypical bacteria were detected in 51.0% of Hong Kong children with asthma exacerbations, which was significantly higher than the detection rate of 27.3% in children with chronic stable asthma. 2. Co-infections of two or more respiratory pathogens were more commonly found in children with asthma exacerbations (10.7%) than in patients with stable asthma (2.6%). 3. Human rhinovirus infection was a significant risk factor for asthma exacerbations. 4. There was no significant association between the severity of asthma exacerbations and respiratory viral or atypical bacterial infections. 5. Routine use of macrolide antibiotics in the treatment of childhood asthma exacerbations should be discouraged.
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 06/2013; 19 Suppl 4:11-4. · 0.87 Impact Factor
  • H S H S Lam · T F Fok · P C Ng
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 12/2012; 18 Suppl 6:23-4. · 0.87 Impact Factor
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    ABSTRACT: 1. Human coronaviruses (HCoVs)were detected in 2.5% of 2982 local children hospitalised for acute respiratory infections in 2005 to 2007. 2. Using the 'pancoronavirus' reverse transcription-polymerase chain reaction assay, detection rates were 0.6% for HCoVNL63,1.2% for HCoV-OC43,0.5% for HCoV-HKU1, and 0.2% for HCoV-229E. Notably, HCoV-NL63 infections were significantly more common among children hospitalised in 2006/2007 (1.2%) than in 2005/2006 (0.3%).3. The peak season for HCoVNL63 infection was autumn(September to October). 4. HCoV-NL63 infection was associated with younger age,croup, febrile convulsion, and acute gastroenteritis. Such disease associations were not found with the other three HCoVs. 5. Most local HCoV-NL63 isolates were closely related to the prototype strain in Netherlands(NL496), but a few were phylogenetically distinct from the major cluster.
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 02/2012; 18 Suppl 2:27-30. · 0.87 Impact Factor
  • H K So · E A S Nelson · R Y T Sung · P C Ng
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    ABSTRACT: To evaluate the implications of replacing Hong Kong's 1993 growth references (HK1993) with the World Health Organization's 2007 references (WHO2007) for children aged 6 to 18 years. Cross-sectional study. Thirty-six randomly selected primary and secondary schools in Hong Kong. A total of 14 842 children and adolescents aged 6 to 18 years in Hong Kong during 2005/06. Creation of age-specific z-scores for height, weight, and body mass index relative to HK1993 and WHO2007 references. Use of WHO2007 instead of HK1993 could classify an additional 1.4% children aged 6 to 10 years and 2.8% children aged 11 to 18 years as having a short stature. Using WHO2007, respective proportions that could be classified as underweight and obese increased by 3.5% and 2.1% among children aged 6 to 10 years, and 5.5% and 1.6% among children aged 11 to 18 years. Use of WHO2007 could increase clinical workload and patient and parent anxiety by 'over-diagnosing' short stature and underweight. Although WHO2007 may have a role in international comparative research, retention of HK1993 would seem appropriate from a clinical perspective.
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 06/2011; 17(3):174-9. · 0.87 Impact Factor
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    ABSTRACT: The present study assessed the relationship between breakfast frequency and measures of obesity in Hong Kong Chinese children aged 9-18 years. A total of 11,570 children (50 % boys) underwent anthropometric measurements and completed a simple self-administered dietary behaviour questionnaire. Their parents completed a questionnaire providing demographic information. Breakfast frequency was assessed by a single question, 'How many days over the past week did you have breakfast?' Children were categorised into three groups: skippers (ate breakfast 0-2 times/week); semi-skippers (ate breakfast 3-4 times/week); non-skippers (ate breakfast 5-7 times/week), to assess all associated characteristics. Of the 3644 primary and 7926 secondary school students, 8 % (8·7 % of boys and 6·9 % of girls) and 14 % (14 % of boys and 15 % of girls), respectively, were breakfast skippers. The prevalence of obesity among breakfast skippers, semi-skippers and non-skippers was, respectively, 9·8, 10·6 and 3·8 % (P < 0·001) for primary school students and 3·9, 3·1 and 2·4 % (P < 0·001) for secondary school students. The 12 % of Hong Kong children aged 9-18 years who skipped breakfast had higher BMI, BMI z-scores and percentage of body fat (PBF) than their counterparts. The dose effects of breakfast frequency (unstandardised regression coefficient, P < 0·001) on BMI and PBF were, respectively, -0·125 kg/m2 and -0·219 % for boys and -0·165 kg/m2 and -0·353 % for girls, adjusting for physical activity per additional breakfast meal per week. Further study is recommended to elucidate whether regular breakfast consumption may have a role in the prevention of childhood obesity.
    The British journal of nutrition 05/2011; 106(5):742-51. DOI:10.1017/S0007114511000754 · 3.45 Impact Factor
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    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 02/2011; 17 Suppl 2:38-40. · 0.87 Impact Factor
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    H K So · R Y T Sung · A M Li · K C Choi · E A S Nelson · J Yin · P C Ng · T F Fok
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    ABSTRACT: The aim of this study was to determine the association between blood pressure and the frequency of structured physical training activity in Chinese adolescents. A total of 9558 students aged 11-18 years underwent anthropometric and blood pressure measurements in a cross-sectional growth study. Structured physical training activity was assessed by two simple self-administered questions and parents were asked to complete a questionnaire providing demographic information. Ninety per cent of eligible students participated in the study, of which 94% provided data on physical training frequency for final analysis. Of the boys, 22.6% and of the girls, 14.5% were physically active with extracurricular school exercise at least twice a week. Over half of the students did not regularly exercise except during physical education classes at school. Blood pressure had a positive correlation with body mass index (BMI). Both systolic blood pressure and diastolic blood pressure were substantially decreased with increased training frequency (P<0.05). Logistic regression adjusting for age, family history of hypertension, BMI and sleep duration showed that exercising two or more times a week had a negative relation with hypertension (odds ratio: 0.63, 95%CI 0.47-0.85). In conclusion, structured physical training activity of two or more times a week has a beneficial effect on blood pressure in Hong Kong children aged 11-18 years.
    Journal of human hypertension 10/2010; 24(10):646-51. DOI:10.1038/jhh.2009.117 · 2.70 Impact Factor
  • Hong Kong Journal of Occupational Therapy 12/2009; 19(2). DOI:10.1016/S1569-1861(10)70017-6 · 0.67 Impact Factor
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    ABSTRACT: To re-examine the prevalence of group B Streptococcus colonisation in our antenatal population, and identify demographic factors associated with carriage. Prospective observational study. A tertiary obstetrics unit in Hong Kong. A total of 1002 pregnant women were recruited at the booking clinic in a tertiary obstetrics unit in Hong Kong. High and low vaginal swabs and rectal swabs were taken for group B Streptococcus culture. Demographic data and delivery outcomes of the recruits were analysed. The prevalence of group B Streptococcus colonisation in our antenatal population was 10.4%. The majority of carriers were identified by low vaginal swabs (78%), while high vaginal swabs and rectal swabs only identified 31% and 30% of the carriers, respectively. Professional women yielded a higher carrier rate than housewives (21% vs 10%, P=0.03). There was no increase in preterm delivery rate in group B Streptococcus carriers. We noted a dramatic increase in the prevalence of group B Streptococcus colonisation in the Hong Kong pregnant population at their booking visit. Professional women had a higher colonisation rate compared to other groups.
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 12/2009; 15(6):414-9. · 0.87 Impact Factor
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    A M Li · C T Au · S K Ng · V J Abdullah · C Ho · T F Fok · P C Ng · Y K Wing
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    ABSTRACT: The natural history of mild childhood obstructive sleep apnoea (OSA) was examined and factors associated with disease progression were identified. Subjects were recruited from an epidemiological study which examined the prevalence of OSA in Chinese children aged 6-13 years. The first 56 consecutive children identified with mild OSA (apnoea-hypopnoea index 1-5) were invited for a repeat assessment 2 years after the diagnosis. 45 children participated in the follow-up study, in 13 of whom (29%) the OSA was found to have worsened. Compared with those in whom OSA had not worsened, the worsened OSA group had a greater increase in waist circumference, a higher prevalence of large tonsils (occupying > or =50% of the airway) at both baseline and follow-up, and a higher prevalence of habitual snoring at both baseline and follow-up. The presence of large tonsils had a positive predictive value of 53% and a negative predictive value of 83% for worsening OSA over a 2-year period. Multivariate linear regression analysis showed that the change in obstructive apnoea-hypopnoea index was associated with age at baseline (beta (SE) = -0.92 (0.34), p = 0.009), gender (male = 1; female = 0) (beta (SE) = 4.69 (1.29), p<0.001), presence of large tonsils at baseline (beta (SE) = 4.36 (1.24), p = 0.001), change in waist circumference (beta (SE) = 0.30 (0.09), p = 0.002) and persistently large tonsils (beta (SE) = 5.69 (1.36), p<0.001) over the 2-year period. Mild OSA in the majority of children does not resolve spontaneously. Subjects with tonsillar hypertrophy, especially boys, should be closely monitored to allow early detection of worsening OSA. Weight control should be stressed in the management of childhood OSA.
    Thorax 09/2009; 65(1):27-31. DOI:10.1136/thx.2009.120220 · 8.29 Impact Factor
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    ABSTRACT: Atopic eczema (AE) is characterized by reduced skin hydration (SH) and impaired integrity of the skin. Proper emollient usage is an important facet of AE management and patients are encouraged to use emollients liberally. To evaluate whether the amount of emollient and skin cleanser used correlates with eczema severity, SH or transepidermal water loss (TEWL), and whether liberal usage alters disease severity, SH and TEWL. We studied SH and TEWL at three common measurement sites on the forearm (antecubital flexure, 20 mm below the antecubital flexure, mid-forearm) and determined the SCORing Atopic Dermatitis (SCORAD) score, Nottingham Eczema Severity Score (NESS), Children's Dermatology Life Quality Index (CDLQI) and the amount of emollient and cleanser usage over a 2-week period in consecutive new patients seen at the paediatric skin clinic of a teaching hospital. In total, 48 subjects and 19 controls were recruited. Patients with AE had significantly higher TEWL and lower SH in the studied sites. Emollient and cleanser usage was significantly higher (P = 0.001 and P = 0.041, respectively) in patients with AE than in controls. The amount of emollient usage was correlated with NESS, SCORAD, CDLQI, TEWL and mid-forearm SH. No such correlation was found with cleanser usage. Regardless of SCORAD, prescribing 130 g/m(2)/week of emollient met the requirement of 95.8% of patients, and 73 g/m(2)/week met that of 85.4%; for the cleanser, prescribing 136 g/m(2)/week met the requirement of 91.7% of patients. Although skin dryness and SH were improved, there was no significant improvement in SCORAD or TEWL after 2 weeks. In terms of global acceptability of treatment, three-quarters of patients with AE and controls rated the combination of cream and cleanser as 'good' or 'very good'. Adequate amounts of emollient and bathing cleanser should be prescribed to patients with AE. These amounts can be conveniently estimated based on body surface area instead of the less readily available tools for disease severity, degree of SH or skin integrity. However, liberal usage of emollients and bathing cleanser alone does not seem to alter disease severity or TEWL within 2 weeks, implying that additional treatments are necessary to manage AE.
    Clinical and Experimental Dermatology 07/2009; 35(1):22-6. DOI:10.1111/j.1365-2230.2009.03341.x · 1.09 Impact Factor
  • H M Cheung · W C W Chu · H S Lam · P C Ng
    Case Reports 02/2009; 2009:bcr2007136903. DOI:10.1136/bcr.2007.136903
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    P K S Chan · E W C Chan · T F Fok · P C Ng · T F Leung
    Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 10/2008; 14(5 Suppl):11-4. · 0.87 Impact Factor

Publication Stats

2k Citations
441.00 Total Impact Points


  • 1994–2011
    • The Chinese University of Hong Kong
      • • Department of Paediatrics
      • • Department of Chemical Pathology
      Hong Kong, Hong Kong
  • 1994–2009
    • Prince of Wales Hospital, Hong Kong
      Chiu-lung, Kowloon City, Hong Kong
  • 1995
    • University of London
      Londinium, England, United Kingdom