Hee Young Kim

Daegu Haany University, Daikyū, Daegu, South Korea

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Publications (140)219.33 Total impact

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    ABSTRACT: Reactive oxygen species (ROS) have been implicated in the development of behavioral sensitization following repeated cocaine exposure. We hypothesized that increased ROS following cocaine exposure would act as signaling molecules in the mesolimbic dopamine (DA) system, which might play an important role in mediating the reinforcing effects of cocaine. The aim of this study was to evaluate cocaine enhancement of brain metabolic activity and the effects of ROS scavengers on cocaine self-administration behavior, cocaine-induced ROS production in the nucleus accumbens (NAc) and cocaine enhancement of DA release in the NAc. Metabolic neural activity monitored by temperature and oxidative stress were increased in NAc following cocaine exposure. Systemic administration of the ROS scavenger N-tert-butyl-α-phenylnitrone (PBN) or 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), either pre- or post-treatment, significantly decreased cocaine self-administration without affecting food intake. Infusion of TEMPOL into the NAc inhibited cocaine self-administration. Increased oxidative stress was found mainly on neurons, but not astrocytes, microglia or oligodendrocytes, in NAc of rats self-administering cocaine. TEMPOL significantly attenuated cocaine-induced enhancement of DA release in the NAc, compared to saline controls. TEMPOL had no effect on the enhancement of DA release produced by the DA transporter inhibitor GBR12909. Taken together, these findings suggest that enhancement of ROS production in NAc neurons contributes to the reinforcing effect of cocaine.
    Addiction Biology 06/2014; · 5.91 Impact Factor
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    ABSTRACT: In the previous study, acupuncture at HT7 has shown to attenuate the self-administration of morphine at a low dose (0.1mg/kg). In this study, it was further investigated whether acupuncture at HT7 could attenuate the morphine self-administration at a high dose (0.5mg/kg) MATERIALS & METHODS: Male Sprague-Dawley rats weighing 270-300g were used. After surgery of catheterization, animals were trained to self-administer morphine solution (0.5mg/kg) using daily 1h session under fixed ratio 1 schedule for 3 weeks. Animals that had shown stable morphine-taking (establish baseline: variation less than 20% of the mean of three consecutive days) were subjected to the acupuncture treatment. Bicuculline and SCH 50911 were used to investigate the possible relation between the effect of acupuncture and the GABA receptor system.
    Neuroscience letters. 06/2014;
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    ABSTRACT: Tsukuba International Conference on Materials Science (TICMS) was held from 28th August to 6th September, 2013 for the celebration of 40th year anniversary of the University of Tsukuba. The conference was organized by the Division of Materials Science, in cooperation with the Graduate School of Pure and Applied Sciences, and Tsukuba Research Center for Interdisciplinary Materials Science.
    IOP Conference Series Materials Science and Engineering 03/2014; 54(1):011001.
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    ABSTRACT: Primary aldosteronism (PA) is now widely recognized to have a higher prevalence than was once thought. In view of its increasing prevalence, we compared chronological changes in clinical manifestations of PA according to different times of diagnosis. In total, 85 patients diagnosed with PA from January 1986 through March 2012 were reviewed retrospectively, based on their medical records. During two periods-1986 to 2005 and 2006 to 2012-41 and 44 patients, respectively, were diagnosed with PA. We compared the clinical and biological characteristics of PA between these periods. The results demonstrate an increasing trend in the prevalence of idiopathic hyperaldosteronism (IHA; p = 0.19). In the 2006 to 2012 period, patients with PA presented with higher serum potassium levels at the time of diagnosis than in the 1986 to 2005 period (p < 0.0002). Adrenal vein sampling (AVS) was performed mostly in the latter period (82.3%) and the diagnostic accuracy of adrenal computed tomography, compared with AVS, was only 56.2%. About 78.0% versus 86.3% of patients had at least one target organ damage (TOD) in the 1986 to 2005 and 2006 to 2012 periods, respectively (p = 0.39). However, patients with TOD were older and had longer durations of hypertension than patients without, in both periods. PA is becoming more prevalent. There was an increasing tendency for IHA, and more PA patients presented with normokalemia than in the earlier period. Early and accurate diagnosis of PA with AVS and proper treatment should have substantial prognostic value.
    The Korean Journal of Internal Medicine 03/2014; 29(2):217-25.
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    ABSTRACT: The course of NAFLD (nonalcoholic fatty liver disease) and associated factors in nonobese subjects are not well established. We investigated contributing factors for the development and regression of NAFLD in nonobese Koreans, and whether they would differ from those of obese subjects METHODS: 2,307 adults aged over 18 years participated in this longitudinal observational study. The mean duration of follow-up was 28.7 (± 13.2) months. The participants were divided into two groups according to the baseline BMI (nonobese group: BMI < 25kg/m(2) , obese group: BMI ≥ 25kg/m(2) ). The presence or absence of NAFLD was assessed by abdominal ultrasonography RESULTS: Body weight change was independently associated with both the development and regression of NAFLD in nonobese subjects as well as obese subjects. Among the subjects who developed NAFLD, the amount of weight change was higher in nonobese subjects compared to obese subjects (1.6 ± 3.9% vs 0.6 ± 4.2%, p = 0.022); and among those who showed regression of NAFLD, the amount of weight change was lower in nonobese subjects (-1.9 ± 4.0% vs. -5.0 ± 4.6%, p < 0.001). Among all the components of metabolic syndrome, only high triglyceride levels (>150mg/dL) at the baseline were significantly associated with both the development and regression of NAFLD in nonobese subjects (ORs, 1.54 (1.10-2.14), and 0.60 (0.38-0.96), respectively) CONCLUSIONS: Body weight change and baseline triglyceride levels were strong indicators for the development and regression of NAFLD in a nonobese population This article is protected by copyright. All rights reserved.
    Liver international: official journal of the International Association for the Study of the Liver 01/2014; · 3.87 Impact Factor
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    ABSTRACT: The effect of Pd content on the microstructure and high-temperature shape memory properties of Ti–Ni–Pd–Cu alloys was investigated. The increase in Pd content led to the increase of transformation temperatures. The volume fraction of two types of precipitates (i.e. TiPdCu and Ti2Pd) also increased with increasing Pd content. Although the formation of these precipitates resulted in an increased resistance against the plastic deformation, the amount of recovery strain decreased during thermal cycling tests at various stress levels. By adjusting the heat treatment time, a high transformation temperature and large amount of recovery strain could be achieved while keeping the enough resistance against the plastic deformation.
    Materials Science and Engineering: A. 01/2014; 602:19–24.
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    ABSTRACT: The effect of cold rolling ratio on precipitation behavior of an annealed Ti50Ni15Pd25Cu10 alloy was investigated. The change in the cold rolling ratio noticeably affected the precipitation behavior mainly due to the difference in the density of heterogeneous nucleation sites provided by the deformation induced defects. Higher cold rolling ratios caused an increase in the density of precipitates which subsequently caused a decrease in the martensitic transformation temperatures and shape recovery strain. It was confirmed that the prior cold deformation ratio is an important parameter to control the nanoscale precipitation behavior of Ti2Pd and TiPdCu type precipitates, both in terms of their overall density and distribution.
    Journal of Alloys and Compounds 01/2014; 599:212–218. · 2.73 Impact Factor
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    ABSTRACT: The effects of Sn content on the stress hysteresis and superelastic properties of Ti–15Nb–3Mo–(0–1.5)Sn were investigated. The stress hysteresis decreased with increasing Sn content due to the suppression of athermal ω phase formation. The addition of Sn was also very effective at increasing the superelastic recovery strain. Due to the dual effect of Sn, which both decreases the Ms and suppresses the athermal ω phase, the stress for inducing martensitic transformation decreased with increasing Sn content up to 1 at.%, then increased on further addition.
    Scripta Materialia. 01/2014; s 72–73:29–32.
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    ABSTRACT: Minimally invasive cardiac surgery (MICS) requires lung isolation. Lung isolation is usually achieved with double-lumen endotracheal tube (DLT). Patients with idiopathic thrombocytopenic purpura (ITP) have an increased risk of bleeding events. We suspected endobronchial hemorrhage after exchange of DLT during induction of anesthesia for replacement of mitral valve in a 62-year-old man with a known ITP. The MICS was stopped and bronchial artery embolization was performed in the angiographic room. In the present case, in order to reduce the risk of bronchial arterial injury in ITP patient we intubated with single lumen endotracheal tube. Lung isolation led to achievement of intermittent total lung deflation. Based on the results, we recommend a high-dose intravenous immunoglobulin therapy and platelet transfusion prior to cardiac surgery in patients with ITP to increase platelet count. Moreover, it is proposed that in order to clear the vision during the operation, ventilation can be held or made intermittent both prior to cardiopulmonary bypass or at its conclusion to permit exposure.
    Korean journal of anesthesiology 01/2014; 66(1):59-63.
  • Plant Omics 10/2013; 6(3):224-230. · 0.35 Impact Factor
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    ABSTRACT: We have previously demonstrated that saikosaponin A (SSA) attenuated morphine self-administration behavior. In the present study, we evaluated the effects of SSA on cocaine-maintained responding using self-administration procedure. Rats self-administered cocaine (0.25mg/kg per infusion) under a fixed ratio 1 schedule of reinforcement during daily 3-hr session. Once stable basal responses were obtained, rats were pretreated with each doses of SSA (1.0, 2.5, 5.0mg/kg) or its vehicle (5% Tween-80) by an intraperitoneal injection 30min before the start of self-administration testing. Additionally, different groups of rats received either the selective GABAB antagonist SCH 50911or the GABAA antagonist bicuculline before systemic administration of SSA at dose of 2.5mg/kg. Results showed that SSA significantly reduced cocaine self-administration without affecting food consumption. SSA inhibition of cocaine reinforced-responding was blocked by SCH 50911, but not bicuculline. Results suggest that SSA may attenuate cocaine-reinforced behavior through activation of GABAB receptors.
    Neuroscience Letters 09/2013; · 2.03 Impact Factor
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    ABSTRACT: This prospective, double-blind, placebo-controlled study was designed to determine the efficacy of nitrous oxide (N2O) in alleviating the pain that followed sequential injection of propofol and rocuronium. A total of 205 adult patients (age, 18-68 years) received one of the following combinations: NaCl and 100 % O2 (group C); 0.5 mg/kg lidocaine and 100 % O2 (group L); NaCl and a mixture of 67 % N2O/O2 (group N); or 0.5 mg/kg lidocaine and a mixture of 67 % N2O/O2 (group LN). Vein occlusion was released after 1 min, and 5 ml propofol was injected over 10 s. Pain was evaluated on a visually enlarged, laminated, numeric rating (0-10) scale. The remainder of the induction dose of propofol (with a 3-ml bolus of normal saline and 0.6 mg/kg rocuronium) was then injected. The response to the rocuronium injection was assessed with a four-point scale (0-3). The incidence and severity of pain from the propofol injection in groups L, N, and LN were significantly lower than those in group C (P < 0.001). Frequency and intensity of the withdrawal response were significantly less in groups N and LN than in groups C and L (no response, P < 0.001; severe response, P < 0.001). Pretreatment with inhaled N2O can reduce the pain associated with propofol and rocuronium injection. Moreover, N2O (with or without lidocaine) is more effective than lidocaine alone in reducing rocuronium-related withdrawal reactions associated with sequential injection of propofol and rocuronium.
    Journal of Anesthesia 08/2013; · 0.87 Impact Factor
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    ABSTRACT: The microstructure and thermal expansion behavior of a Ti–23Nb–2Zr–0.7Ta–1.2O alloy (Gum metal) were investigated. A systematic diffraction pattern analysis using transmission electron microscopy revealed that a {11¯0}〈110〉-type transverse lattice modulation is present in the Ti–23Nb–2Zr–0.7Ta–1.2O alloy. Martensite-like nanodomains corresponding to {11¯0}〈110〉-type lattice modulations were observed in dark-field micrographs. Six variants of lattice modulation were confirmed to be distributed equivalently in the β phase in the annealed condition. Cold rolling resulted in preferential growth of a nanodomain variant which is most suited to releasing the applied stress although the long-range martensitic transformation was prevented by the local stress of the domain structure caused by oxygen atoms. It is suggested that the very small thermal expansion coefficient in the as-rolled specimen is caused by the preferential growth of the nanodomain variant due to residual stress.
    Acta Materialia. 08/2013; 61(13):4874–4886.
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    ABSTRACT: The combined effects of work hardening and precipitation strengthening were employed to improve the cyclic stability of TiNiPdCu-based high-temperature shape memory alloys. Annealing after cold deformation resulted in the formation of nano-scale TiPdCu and Ti2Pd precipitates, stable at high temperatures in Ti50Ni25−xPd25Cux alloys. The nano-scale precipitates were also observed to retard recovery/recrystallization processes at higher temperatures. It was found that the combined effects of work hardening and precipitation strengthening remarkably enhanced the high-temperature stability of the Ti50Ni20Pd25Cu5 alloy and increased its maximum working temperature range while keeping the transformation temperatures and recovery strains at sufficiently high levels. Precipitation strengthening helped to greatly improve the high-temperature cyclic stability of the alloy. Creep tests at 673 K under 500 MPa confirmed that the better high-temperature cyclic stability of the precipitate-containing alloy was mainly due to its higher creep resistance.
    Acta Materialia. 08/2013; 61(13):4797–4810.
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    ABSTRACT: The phosphodiesterase inhibitor cilostazol has beneficial effects on atherosclerosis by virtue of vasodilatory and antiplatelet effects. However, less is known about the effect of cilostazol on arterial stiffness and biochemical markers related to vascular inflammation and endothelial dysfunction in type 2 diabetic patients with metabolic syndrome. In this randomized, double-blind, crossover trial, 45 diabetic patients with metabolic syndrome were randomly assigned to either the cilostazol group (50 mg for 2 weeks, 100 mg for 6 weeks) or placebo group for an 8-week treatment phase, and then crossed over. Brachial-ankle pulse wave velocity (baPWV) and serum levels of inflammatory cytokines and vascular cellular adhesion molecules were measured before and after each treatment phase. Compared with the placebo group, the mean baPWV did not improve in the cilostazol group (mean difference 31.42 cm/sec, 95% CI -55.67 to 118.5). Cilostazol treatment significantly reduced soluble vascular cellular adhesion molecule-1 (sVCAM-1) level (from 1288.7 +/- 285.6 to 1168.2 +/- 252.3 ng/dL, P = 0.0003), and there was also significant mean difference between groups (mean difference 105.18 ng/dL, 95% CI 10.65 to 199.71). However, other biochemical markers including lipid profiles, high sensitivity C-reactive protein, adiponectin, interleukin-6, tumor necrosis factor-alpha, monocyte chemotactic protein-1, and soluble intercellular adhesion molecule-1 did not improve with cilostazol treatment. Cilostazol treatment significantly reduced serum sVCAM-1 level, but this short term treatment was not associated with beneficial effect on arterial stiffness and other inflammatory markers.Trial registration(Clinical trial reg. no. NCT00573950, clinicaltrials.gov.).
    Diabetology and Metabolic Syndrome 07/2013; 5(1):41. · 1.92 Impact Factor
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    ABSTRACT: One feature of neuropathic pain is a reduced spinal GABAergic inhibitory function. However, the mechanisms behind this attenuation remain to be elucidated. This study investigated the involvement of reactive oxygen species in the spinal GABA neuron loss and reduced GABA neuron excitability in spinal nerve ligation (SNL) model of neuropathic pain in mice. The importance of spinal GABAergic inhibition in neuropathic pain was tested by examining the effects of intrathecally administered GABA receptor agonists and antagonists in SNL and naïve mice, respectively. The effects of SNL and antioxidant treatment on GABA neuron loss and functional changes were examined in transgenic GAD67-EGFP mice. GABA receptor agonists transiently reversed mechanical hypersensitivity of the hind paw in SNL mice. On the other hand, GABA receptor antagonists made naïve mice mechanically hypersensitive. Stereological analysis showed that the numbers of enhanced green fluorescent protein positive (EGFP+) GABA neurons were significantly decreased in the lateral superficial laminae (I-II) on the ipsilateral L5 spinal cord after SNL. Repeated antioxidant treatments significantly reduced the pain behaviors and prevented the reduction in EGFP+ GABA neurons. The response rate of the tonic firing GABA neurons recorded from SNL mice increased with antioxidant treatment, whereas no change was seen in those recorded from naïve mice, which suggested that oxidative stress impaired some spinal GABA neuron activity in the neuropathic pain condition. Together the data suggest that neuropathic pain, at least partially, is attributed to oxidative stress which induces both a GABA neuron loss and dysfunction of surviving GABA neurons.
    Pain 07/2013; · 5.64 Impact Factor
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    ABSTRACT: We aimed to verify the effectiveness of semi-permeable membrane devices (SPMDs) for monitoring hydrophobic organic compounds, such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), that are not easy to detect using conventional grab samples (because of their low concentrations), in water. We used SPMDs and grab samples to monitor PCBs and PBDEs upstream and downstream of a sewage treatment plant (STP) in the Suyeong River in Busan, Korea. Concentrations in three different phases (freely dissolved, apparently dissolved, and particulate) were measured, to investigate the aquatic fate of PCBs and PBDEs. The freely dissolved (SPMD) concentrations were 2-3 times higher than the apparently dissolved and particulate phase (grab sample) concentrations. No meaningful relationships were found between the total PCB and PBDE concentrations of the grab sample and SPMD sample because of the different partitioning behaviors and detection frequencies of the individual chemicals. However, the summed concentrations of specific PCB and PBDE congeners (that were abundant in all samples) in the grab and SPMD samples correlated well (r(2)=0.7451 for PCBs 28+52+153, r(2)=0.9987 for PBDEs 28+47+99). The PBDE concentrations measured using SPMDs decreased with increasing distance from the STP, but no apparent dilution effect was found in the grab samples. Our results show that SPMDs could be used to support grab sampling for specific chemicals, or to trace chemical sources (such as STPs) to the aquatic environment.
    Science of The Total Environment 07/2013; · 3.26 Impact Factor
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    ABSTRACT: OBJECTIVES: Morphine causes physical and psychological dependence for individuals after repeated-use. Above all, our previous study showed that acupuncture attenuated reinstatement of morphine-seeking behavior induced by pharmacological cue. In this study, we investigated whether acupuncture could suppress the reinstatement of morphine-seeking behavior induced by the combination of environmental and phamacological cues and the possible neuronal involvement. MATERIALS AND METHODS: Male Sprague-Dawley rats were trained to self-administer morphine (1.0 mg/kg) for three weeks. Following the withdrawal phase (seven days), the effects of acupuncture on reinstatement of morphine-seeking behavior were investigated. For the investigation of neuronal involvement, the GABAA receptor antagonist bicuculline and the GABAB receptor antagonist SCH 50911 were pre-treated. RESULTS: Morphine-seeking behavior induced by combination of re-exposure to the operant chamber and morphine injection was suppressed perfectly by acupuncture at SI5, but not at the control acupoint LI5 and this effect was blocked by pre-treatment with the GABA receptor antagonists. CONCLUSIONS: This study suggests that acupuncture at SI5 can be considered as a predominant therapy for the reinstatement of morphine-seeking behavior in humans.
    Neuroscience Letters 05/2013; · 2.03 Impact Factor
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    ABSTRACT: Radioactive iodine (RAI) therapy has been used as a treatment option for Graves' disease, and it has been widely accepted to be safe. On the other hand, some evidence suggests that RAI therapy is possibly associated with a small increased risk of thyroid cancer. Herein, we report a rare case of anaplastic thyroid carcinoma (ATC) associated with Graves' disease, following RAI treatment. A 42-year-old woman had been diagnosed with Graves' disease and although she was treated with an antithyroid drug, she remained in a hyperthyroid state, which led to two RAI treatments. More than 10 years later, the patient revisited our clinic due to hoarseness, dysphagia, and dyspnea, which had lasted for 2 months. Neck computed tomography suggested thyroid carcinoma and a lymph node biopsy showed metastatic papillary carcinoma. The patient underwent total thyroidectomy and was finally diagnosed as having an ATC. It is not clear if the occurrence of ATC reported here was influenced by the RAI therapy or alternatively, it may only represent the delayed recognition of a rare change in the natural history of Graves' disease. Nevertheless, this report is worthwhile since it presents a very rare case of ATC that occurred eleven years after the RAI therapy for Graves' disease.
    Endocrinology and metabolism (Seoul, Korea). 03/2013; 28(1):61-4.
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    ABSTRACT: Administration of cocaine increases locomotor activity by enhancing dopamine transmission. To explore the peripheral mechanisms underlying acupuncture treatment for drug addiction, we developed a novel mechanical acupuncture instrument (MAI) for objective mechanical stimulation. The aim of this study was to evaluate whether acupuncture inhibition of cocaine-induced locomotor activity is mediated through specific peripheral nerves, the afferents from superficial or deep tissues, or specific groups of nerve fibers. Mechanical stimulation of acupuncture point HT7 with MAI suppressed cocaine-induced locomotor activity in a stimulus time-dependent manner, which was blocked by severing the ulnar nerve or by local anesthesia. Suppression of cocaine-induced locomotor activity was elicited after HT7 stimulation at frequencies of either 50 (for Meissner corpuscles) or 200 (for Pacinian corpuscles) Hz and was not affected by block of C/Aδ-fibers in the ulnar nerve with resiniferatoxin, nor generated by direct stimulation of C/Aδ-fiber afferents with capsaicin. These findings suggest that HT7 inhibition of cocaine-induced locomotor activity is mediated by A-fiber activation of ulnar nerve that originates in superficial and deep tissue.
    PLoS ONE 01/2013; 8(11):e81018. · 3.73 Impact Factor

Publication Stats

639 Citations
219.33 Total Impact Points


  • 2012–2014
    • Daegu Haany University
      Daikyū, Daegu, South Korea
  • 2007–2014
    • Korea University
      • Department of Internal Medicine
      Sŏul, Seoul, South Korea
  • 2004–2014
    • University of Tsukuba
      Tsukuba, Ibaraki, Japan
  • 2013
    • Korea Institute of Toxicology
      Sŏul, Seoul, South Korea
  • 2008–2013
    • University of Texas Medical Branch at Galveston
      • Department of Neuroscience and Cell Biology
      Galveston, TX, United States
  • 2004–2012
    • Ajou University
      • Department of Pharmacology
      Seoul, Seoul, South Korea
  • 2011
    • Daegu University
      • College of Oriental Medicine
      Taegu, Daegu, South Korea
  • 2010
    • University of Pittsburgh
      • School of Nursing
      Pittsburgh, PA, United States
  • 2006–2009
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
    • Dong-A University
      Tsau-liang-hai, Busan, South Korea
  • 2000–2007
    • Korea Research Institute of Chemical Technology
      • Division of Advanced Material
      Daiden, Daejeon, South Korea
  • 2003
    • Korea Advanced Institute of Science and Technology
      • Department of Chemical and Biomolecular Engineering
      Seoul, Seoul, South Korea
  • 1998
    • Chungnam National University
      • Department of Food and Nutrition
      Daiden, Daejeon, South Korea