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ABSTRACT: Baker's yeast biomass was pretreated by ethanol and caustic soda, and then the pristine baker's yeast, ethanol pretreated baker's yeast (ethanol-baker's yeast) and caustic soda pretreated baker's yeast (caustic-baker's yeast) were utilized as biosorbents to adsorb Cu(2+) in aqueous solution. The influence of different parameters on Cu(2+) uptake by the three biomasses, such as initial Cu(2+) concentration, initial pH of solution, contact time and temperature, was studied. The mechanism of Cu(2+) binding by biomass was investigated by a number of techniques. Evidence from potentiometric titration revealed that the concentration of carboxyl and amino groups is higher on the caustic and ethanol-baker's yeast compared to the pristine baker's yeast and FTIR spectra confirmed carboxyl, and amino groups on the surface of baker's yeast could be available for characteristic coordination bonding with Cu(2+). In addition, SEM and Zeta potential of the three samples show that caustic and ethanol-pretreatment resulted in the change of baker's yeast surface structure and charge which is relative to adsorption. These results demonstrate that the increase of biosorption capacity for Cu(2+) by ethanol and caustic-baker's yeast was attributed to the increase and exposure of carboxyl and amino groups on the surface of biomass sample.
Journal of hazardous materials 02/2010; 178(1-3):1085-93. · 4.14 Impact Factor
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ABSTRACT: Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to breast carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the relationship.
We conducted a search in the Medline, EMBASE, OVID, Sciencedirect, and Chinese National Knowledge Infrastructure (CNKI) without a language limitation, covering all papers published up to Jan 2009. The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications.
A total of seventeen case-control studies, including 12226 cases and 10782 controls, met the included criteria and thus were selected. Ultimately, the relevant data were extracted and further analyzed using systematic meta-analyses. Overall, no associations of TP53 codon 72 polymorphisms with breast carcinoma were observed (for Arg/Arg vs Pro/Pro: OR = 1.20; 95%CI = 0.96-1.50; for dominant model: OR = 1.12; 95%CI = 0.96-1.32; for recessive model: OR = 1.13; 95%CI = 0.98-1.31). In the subgroup analysis by ethnicity, statistically similar results were obtained when the data were stratified as Asians, Caucasians and Africans.
Collectively, the results of the present study suggest that TP53 codon 72 polymorphisms might not be a low-penetrant risk factor for developing breast carcinoma.
Journal of Experimental & Clinical Cancer Research 09/2009; 28:115. · 2.15 Impact Factor
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ABSTRACT: The anatase nano-TiO2 powder, with crystal size between 40 and 80 nm, was prepared by the liquid phase hydrolysis of TiCl4. At the same time, the nano-TiO2 was utilized with the baker’s yeast biomass as a composite adsorbent to adsorb the Cu ions in the artificial aqueous solution.
The investigation showed that the composite adsorbent had a fine adsorption efficiency. The TiO2 in the composite adsorbent could cooperate well with baker’s yeast to improve the adsorbing capability of Cu2+ under the following experimental conditions as well: a quantity of composite adsorbent of 5 g·L−1, pH⩾4.0, an adsorption time of 40 min and an initial concentration of Cu ions of 10 mg·L−1. In addition, the results of measurements, obtained with a scanning electron microscope, an infrared spectrophotometer and
a Zeta potential analyzer, revealed that the baker’s yeast and nano-TiO2 produced the composite adsorbent through coordination and hydrogen bonds in particular, etc. The stability of the composite
adsorbent and the amount of titania loaded were largely dependent on the concentration of hydrogen ion in the solution.
Chinese Science Bulletin 04/2008; 53(9):1365-1372. · 1.32 Impact Factor
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ABSTRACT: Previous reports have implicated epithelial-mesenchymal transition (EMT) as a major cause of cancer. Snail, a novel zinc finger transcription factor, was suggested to be an important inducer of EMT and therefore be involved in different phases of tumorigenicity. However, whether Snail could increase chemoresistance of cancer cells to chemotherapeutic agent remains unclear. To evaluate the roles and possible mechanisms of Snail in chemoresistance of lung cancer cells to cisplatin, we utilized RNA interference to knockdown Snail expression in A549 cells and further assessed the cell viability and apoptosis as well as possible signaling transduction pathways. The data showed that Snail depletion sensitized A549 cells to cisplatin possibly by inducing activation of JNK/mitochondrial pathway, suggesting critical roles of Snail in A549 cell chemoresistance to cisplatin and raising the possibility of Snail depletion as a promising approach to lung cancer therapy.
Lung Cancer 04/2008; 62(1):8-14. · 3.43 Impact Factor
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ABSTRACT: To explore the sequential variation of pulmonary flow spectrum and its value on evaluation of risk for pulmonary resection in perioperative patients with lung cancer.
Forty-nine patients with lung cancer who underwent pneumonectomy (12 cases) and lobectomy (37 cases) were observed for the values of Doppler pulmonary flow spectrum before operation, on the 3-5 days and 8-10 days postoperatively. Moreover the patients were divided into different groups according to the different operative procedures and with or without postoperative cardiac arrhythmia.
Doppler pulmonary flow spectrum changed in all cases who underwent pneumonectomy and lobectomy from 3 to 5 days postoperatively. These changs included prolonged preejection period (PEP), shortened acceleration time (ACT), increased PEP/ACT ratio, increased pulmonary artery mean pressure (PAMP), and increased pulmonary vascular resistance (PVR). There were significant differences comparing with those before operation ( P < 0.01). The patients who underwent lobectomy recovered to the same level of pre operation on the 8th to 10th postoperative days. However, the changes of pulmonary flow spectrum continuously existed in the patients who underwent pneumonectomy on the 8th to 10th postoperative days. There were significant differences of pulmonary flow spectrum between patients with postoperative arrhythmia and without postoperative arrhythmia before operation.
Pulmonary hemodynamic obviously changes after pulmonary resection in the patients with lung cancer and the changes last longer in pneumonectomy patients. Patients with postoperative cardiac arrhythmia have marked pulmonary hemodynamic changes before operation. Doppler pulmonary flow spectrum can not only be used to analyse the pulmonary hemodynamic changes for those cases undergoing pulmonary resection after operation, but also to evaluate the risk of pulmonary resection before operation.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 08/2004; 7(4):351-3.
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ABSTRACT: A magnetic adsorbent, EDTAD-functionalized Saccharomyces cerevisiae, has been synthesized to behave as an adsorbent for heavy metal ions by adjusting the pH value of the aqueous solution to make carboxyl and amino groups protonic or non-protonic. The bifunctional Saccharomyces cerevisiae (EMS) were used to remove lead(II) and cadmium(II) in solution in a batch system. The results showed that the adsorption capacity of the EMS for the heavy metal ions increased with increasing solution pH, and the maximum adsorption capacity (88.16 mg/g for Pb2+, 40.72 mg/g for Cd2+) at 10 °C was found to occur at pH 5.5 and 6.0, respectively. The adsorption process followed the Langmuir isotherm model. The regeneration experiments revealed that the EMS could be successfully reused.Highlights► The EDTAD-functionalized Saccharomyces cerevisiae (EMS) was prepared. ► EMS was used to dispose the waste water of lead(II) and cadmium(II). ► The adsorption/desorption mechanism of EMS for lead(II) and cadmium(II) was studied.
Applied Surface Science 257(23):9809-9816. · 2.10 Impact Factor
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ABSTRACT: The magnetic baker's yeast biomass (MB) was prepared by combining baker's yeast and nano-Fe3O4 using glutaraldehyde as a cross link agent. The MB was successfully used for the biosorption of methyl violet (MV) and was easily recycled by using an applied magnetic field. The mechanism of MV biosorption by MB was investigated by SEM, XRD, FTIR, zeta potential and potentiometric titration. The results revealed that nano-Fe3O4, with spherical and granular morphology, were distributed on the surface of baker's yeast biomass. The functional groups such as carboxyl, hydroxyl and amino groups found on the surface of MB may be responsible for MV biosorption. The optimal biosorption conditions were determined as pH 6.0, MV concentration 300 mg/L and contact time 30 min. The biosorption capacity in the optimal conditions was 60.84 mg/g. The biosorption process followed the pseudo-second-order kinetic model and the Langmuir isotherm equation. The thermodynamic parameters ΔG°, ΔH° and ΔS° showed that the biosorption was feasible, spontaneous and endothermic. The desorption and regeneration experiments were investigated and the biosorption/desorption cycles of MV were repeated three times. The MB regeneration efficiency and the MV recovery efficiency were 82.64% and 84.54% respectively in the third cycle by using HAc as an eluent solution.
Chemical Engineering Journal.
