P. Buisson

Université de Picardie Jules Verne, Amiens, Picardie, France

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Publications (11)2.31 Total impact

  • [show abstract] [hide abstract]
    ABSTRACT: The congenital mesoblastic nephroma (CMN) described by Bolande et al. in 1967 is a renal tumor often discovered in neonatal period and early childhood. It's usually considered as a benign tumor with good prognostic for which nephrectomy is the reference treatment. But some cases of local recidives and metastatic sites had been described in the literature. For these reasons histologic analysis and quality of follow up are very important. In this observation we describe a neonatal kind of CMN and we discuss this pathology.
    Progrès en Urologie 03/2012; 22(3):189-91. · 0.80 Impact Factor
  • [show abstract] [hide abstract]
    ABSTRACT: The congenital mesoblastic nephroma (CMN) described by Bolande et al. in 1967 is a renal tumor often discovered in neonatal period and early childhood. It's usually considered as a benign tumor with good prognostic for which nephrectomy is the reference treatment. But some cases of local recidives and metastatic sites had been described in the literature. For these reasons histologic analysis and quality of follow up are very important. In this observation we describe a neonatal kind of CMN and we discuss this pathology.
    Progrès en Urologie. 03/2012; 22(3):189–191.
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    ABSTRACT: Cystinuria is an inherited autosomal-recessive disorder of renal reabsorption of the dibasic amino acids. It is the cause of about 6% of all kidney stones observed in children. Cystine is relatively insoluble at the physiological pH of urine. Cystine stones are characteristic and frequent recurrences are observed. We report on 4 cases and describe the initial presentation (obstructive renal failure, urinary sepsis, familial screening) and the medical and surgical management. Medical management is mainly based on hyperhydration and urine alkalinization. Long-term therapy with sulfhydryl agents to prevent formation of renal stones seems to be effective but adverse side effects are frequent, requiring the withdrawal of treatment. Urological management has evolved from surgical stone removal to minimally invasive procedures (extracorporeal shock wave lithotripsy, ureteroscopy).
    Archives de Pédiatrie 03/2011; · 0.36 Impact Factor
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    ABSTRACT: Objectifs La dilatation intestinale en amont d’une atrésie semble modifier la motricité. Un modèle animal de dilatation chronique a été créé afin d’étudier le segment iléal dilaté avant puis après remise en continuité (RC). Matériel et Méthodes Trois groupes de 7 rats ont été constitués : -témoins ;-fantômes (laparotomie à 4 et 6 semaines) ;-opérés (anse borgne iso-péristaltique iléale à 4 semaines, RC à 6). L’amplitude de contraction des lambeaux d’iléon a été étudiée in vitro en réponse à des stimulations électriques et pharmacologiques, l’épaisseur des couches musculaires déterminée par microscopie photonique. Résultats Les stimulations ont entraîné une contraction significative des lambeaux. Par rapport aux fantômes et témoins, l’amplitude des contractions de l’anse RC n’est pas significativement différente tandis que celle de l’anse dilatée l’est (p < 0,05). L’épaisseur des couches musculaires de l’anse dilatée est augmentée de 300% (p < 0,001) et de 250% après RC (p < 0,01). Discussion Notre étude montre des altérations de la motricité intestinale et une hyperplasie musculaire après obstruction prolongée avec possible récupération après RC. Ceci incite à poursuivre l’attitude classique soit une résection limitée.
    Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2010; 17(6):10-10.
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    ABSTRACT: A rat animal model of left colostomy was found to significantly impair the growth curve of rats. Assessment of the intestinal flora showed that colostomy mostly affects the cecal but not colonic microflora. Generally, the number of enterococci was increased in both ileum and cecum; cecal lactobacilli also rose, accounting for a promotion of lactic acid bacteria in colostomised rats. No significant differences between colostomised, laparotomised and control rats could be observed for the translocation of intestinal bacteria to internal organs of rats (i.e. spleen, kidneys, lungs or liver), whatever their diet. Heat-killed Lactobacillus acidophilus strain LB administration (dead probiotic bacteria) tended to exhibit a stimulatory effect on bifidobacteria, probably affecting the culture-medium fermentation substances included in the pharmaceutical product. This effect was abolished by laparotomy and colostomy. A trend towards a probiotic-like effect, not susceptible to colostomy, was also witnessed as counts of lactobacilli tended to increase in both cecum and colon of all animals fed with L. acidophilus LB.
    Folia Microbiologica 02/2008; 53(1):89-93. · 0.79 Impact Factor
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    ABSTRACT: Introduction et but de l’étude La chirurgie digestive néonatale est souvent source de déséquilibre de l’écologie microbienne et d’atteinte du métabolisme intestinal pouvant devenir nocif, mais que l’on peut contrecarrer par les probiotiques. Le but de ce travail est d’évaluer l’impact du stress chirurgical sur la composition du mucus intestinal et l’activité de la phosphatase alcaline chez le jeune rat et l’effet bénéfique de L. acidophilus. Matériel et méthods Trente-six rats de race Wistar (100- 150 g) ont été inclus et répartis en 6 groupes : Gr Témoin (GT, n=6), n’a subi aucun traitement, Gr Fantôme, (GF, n=6), a subi une simple laparotomie, Gr Colostomisé, (GC, n=6); Gr témoin bis (GTbis, n=6), Gr Fantôme bis (GFbis, n=6)et Gr colostomisé bis (GCbis, n=6), ces 3 derniers groupes ont reçu une dose journalière de 10log9 L. acidophilus tués par la chaleur (Lactéol fort®). A J15, sacrifice des animaux et prélèvement de fragments d’intestins de 2 à 3 cm de l’iléon, du cæcum et du côlon pour le dosage des protéines, des sucres, des acides sialiques et pour l’étude de l’activité de la phosphatase alcaline. Résultats Ni le stress chirurgical ni l’admnistration de L. acidophilus n’influent sur le poids des animaux. La composition du mucus est modifiée par une expression faible des protéines, des sucres et des acides sialiques chez les animaux traités au probiotique et ceci quel que soit le fragment d’intestin (p<0.05 vs GT, GF, GC). L’activité de la phosphatase alcaline est perturbée suite à l’acte chirurgical, alors que le traitement par le L. Acidophilus la stimule remarquablement en particulier dans l’iléon (p<0.05 vs GT, GF, GC). Conclusions Nous observons un impact du stress chirurgical sur l’expression du mucus et de l’activité de la phosphatase alcaline ainsi que le rôle bénéfique du traitement par L. acidophilus sur l’homéostasie intestinale.
    Nutrition Clinique Et Metabolisme - NUTR CLIN METAB. 01/2007; 21:77-77.
  • Journal of Pediatric Gastroenterology and Nutrition - J PEDIAT GASTROENTEROL NUTR. 01/2004; 39.
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    ABSTRACT: The aim of this study was to evaluate the change in ureteropelvic junction management, from surgical correction to observation of the hydronephrosis. We checked wether or not it was deleterious for kidney. We retrospectively reviewed 96 charts between 1988 and 1998. Initial ultrasonography, and voiding cystourethrogram were available for all cases. Intravenous urography and diuretic renography were studied when available. Minimal follow-up of patients was one year. Patients were divided into three groups: surgery right away, surgery after observation, and observation only. Later was the diagnosis, more significant were the hydronephrosis and impairment of renal function (p < 0.01). In group operated on right away (69 cases), drainage improved, hydronephrosis decreased, but renal function did not improve significantly (p = 0.37). Sixteen patients were operated on after observation without deleterious effect for kidney. Eleven patients were only observed: hydronephrosis progressively decreased. Initial radiological results were not different between the last two groups (p > 0.05), and were not predictive of their course. Initial non operative management of hydronephrosis was not dangerous for renal function. It is advisable to detect at the earliest all signs of obstruction, because surgery improves renal drainage but not renal function.
    Archives de Pédiatrie 04/2003; 10(3):215-20. · 0.36 Impact Factor
  • Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2003; 10.
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    ABSTRACT: Purpose. – The aim of this study was to evaluate the change in ureteropelvic junction management, from surgical correction to observation of the hydronephrosis. We checked wether or not it was deleterious for kidney.Materials and methods. – We retrospectively reviewed 96 charts between 1988 and 1998. Initial ultrasonography, and voiding cystourethrogram were available for all cases. Intravenous urography and diuretic renography were studied when available. Minimal follow-up of patients was one year. Patients were divided into three groups: surgery right away, surgery after observation, and observation only.Results. – Later was the diagnosis, more significant were the hydronephrosis and impairment of renal function (p 0.01). In group operated on right away (69 cases), drainage improved, hydronephrosis decreased, but renal function did not improve significantly (p = 0.37). Sixteen patients were operated on after observation without deleterious effect for kidney. Eleven patients were only observed: hydronephrosis progressively decreased. Initial radiological results were not different between the last two groups (p > 0.05), and were not predictive of their course.Conclusion. – Initial non operative management of hydronephrosis was not dangerous for renal function. It is advisable to detect at the earliest all signs of obstruction, because surgery improves renal drainage but not renal function.
    Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2003; 10(3):215-220.
  • Archives De Pediatrie - ARCHIVES PEDIATRIE. 01/2003; 10.