Publications (13)28.78 Total impact
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Article: Preferential patterns of myocardial iron deposit by multislice multiecho T2* CMR in thalassemia major patients
Journal of Cardiovascular Magnetic Resonance 05/2012; 12:1-2. · 3.72 Impact Factor -
Article: Different patterns of myocardial iron overload by T2* Cardiovascular MR as markers of risk for cardiac complication in thalassemia major.
Journal of Cardiovascular Magnetic Resonance 02/2012; 14 Suppl 1:M1. · 3.72 Impact Factor -
Article: Heart T2* for prediction of cardiac complications in well-treated thalassemia major patients.
Journal of Cardiovascular Magnetic Resonance 02/2012; 14 Suppl 1:P195. · 3.72 Impact Factor -
Article: Are the preferential patterns of myocardial iron overload preserved at the CMR follow-up?
Journal of Cardiovascular Magnetic Resonance 02/2012; 14 Suppl 1:P190. · 3.72 Impact Factor -
Article: Diabetes mellitus and cardiac complications in thalassemia major patients.
Journal of Cardiovascular Magnetic Resonance 02/2012; 14 Suppl 1:P189. · 3.72 Impact Factor -
Article: Feasibility, reproducibility, and reliability for the T*2 iron evaluation at 3 T in comparison with 1.5 T.
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ABSTRACT: This study aimed to determine the feasibility, reproducibility, and reliability of the multiecho T*(2) Magnetic resonance imaging technique at 3 T for myocardial and liver iron burden quantification and the relationship between T*(2) values at 3 and 1.5 T. Thirty-eight transfusion-dependent patients and 20 healthy subjects were studied. Cardiac segmental and global T*(2) values were calculated after developing a correction map to compensate the artifactual T*(2) variations. The hepatic T*(2) value was determined over a region of interest. The intraoperator and interoperator reproducibility for T*(2) measurements at 3 T was good. A linear relationship was found between patients' R *2 (1000/T*(2) ) values at 3 and 1.5 T. Segmental correction factors were significantly higher at 3 T. A conversion formula returning T*(2) values at 1.5 T from values at 3 T was proposed. A good diagnostic reliability for T*(2) assessment at 3 T was demonstrated. Lower limits of normal for 3 T T*(2) values were 23.3 ms, 21.1 ms, and 11.7 ms, for the global heart, mid-ventricular septum, and liver, respectively. In conclusion, T*(2) quantification of iron burden in the mid-ventricular septum, global heart, and no heavy-moderate livers resulted to be feasible, reproducible, and reliable at 3 T. Segmental heart T*(2) analysis at 3 T may be challenging due to significantly higher susceptibility artifacts.Magnetic Resonance in Medicine 11/2011; 68(2):543-51. · 2.96 Impact Factor -
Article: Regional and global pancreatic T*2 MRI for iron overload assessment in a large cohort of healthy subjects: normal values and correlation with age and gender.
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ABSTRACT: Multiecho gradient-echo T*2 magnetic resonance imaging is a well-established technique for iron overload assessment but there are few reports concerning the pancreas. The aim of this work was to assess the feasibility and reproducibility of the magnetic resonance imaging for measuring pancreatic regional and global T*2 values, to establish the lower limit of normal in a large cohort of healthy subjects and to correlate the measured values with age and gender. One hundred and twenty healthy subjects (61 males, 51±17 years) underwent magnetic resonance imaging (1.5T) using a multiecho gradient-echo T*2 sequence. T*2 measurements were performed in pancreatic head, body, and tail. The global value was calculated as the mean. Measurement of pancreatic T*2 values was feasible in all subjects. For the T*2 global value the coefficient of variation for intraoperator and interoperator reproducibility were 7.7% and 13%, respectively. The global T*2 values ranged from 24 to 52 ms with the lower limit of normal of 26 ms. There were no significant differences among the regional pancreatic T*2 values. No significant correlation was found between T*2 and patient age or gender. In conclusion, pancreatic T*2 measurements appear to be feasible, reproducible, nontime-consuming and reliable. Gender- and age-related differences concerning pancreatic T*2 were not found.Magnetic Resonance in Medicine 03/2011; 65(3):764-9. · 2.96 Impact Factor -
Article: Different patterns of myocardial iron overload by multislice T2* Cardiovascular MR as markers of risk for cardiac dysfunction in thalassemia major
Journal of Cardiovascular Magnetic Resonance. 01/2011; -
Article: Left Ventricular Volumes, Mass and Function normalized to the body surface area, age and gender from CMR in a large cohort of well-treated Thalassemia Major patients without myocardial iron overload
Journal of Cardiovascular Magnetic Resonance. 01/2011; -
Article: Preferential patterns of myocardial iron overload by multislice multiecho T*2 CMR in thalassemia major patients.
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ABSTRACT: T*(2) multislice multiecho cardiac MR allows quantification of the segmental distribution of myocardial iron overload. This study aimed to determine if there were preferential patterns of myocardial iron overload in thalassemia major. Five hundred twenty-three thalassemia major patients underwent cardiac MR. Three short-axis views of the left ventricle were acquired and analyzed using a 16-segment standardized model. The T*(2) value on each segment was calculated, as well as the global value. Four main circumferential regions (anterior, septal, inferior, and lateral) were defined. Significant segmental variability was found in the 229 patients with significant myocardial iron overload (global T*(2) <26 ms), subsequently divided into two groups: severe (global T*(2) <10 ms) and mild to moderate (global T*(2) between 10 and 26 ms) myocardial iron overload. A preferential pattern of iron store in anterior and inferior regions was detected in both groups. This pattern was preserved among the slices. The pattern could not be explained by additive susceptibility artifacts, negligible in heavily iron-loaded patients. A significantly higher T*(2) value in the basal slice was found in patients with severe iron overload. In conclusion, a segmental T*(2) cardiac MR approach could identify early iron deposit, useful for tailoring chelation therapy and preventing myocardial dysfunction in the clinical setting.Magnetic Resonance in Medicine 07/2010; 64(1):211-9. · 2.96 Impact Factor -
Article: Preferential patterns of myocardial iron deposit by multislice multiecho T2* CMR in thalassemia major patients
Journal of Cardiovascular Magnetic Resonance. 01/2010; -
Article: Standardized T2* map of a normal human heart to correct T2* segmental artefacts; myocardial iron overload and fibrosis in thalassemia intermedia versus thalassemia major patients and electrocardiogram changes in thalassemia major patients.
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ABSTRACT: Studies of the standardized, 3D, 16-segments map of the circumferential distribution of T2* values, of cardiovascular magnetic resonance (CMR) in thalassemia major (TM) and thalassemia intermedia (TI) patients and of electrocardiogram (ECG) changes associated with TM, have been carried out. Similarly, the segment-dependent correction map of the T2* values and the artifactual variations in normal subjects and the T2* correction map to correct segmental measurements in patients with different levels of myocardial iron burden have been evaluated. Cardiovascular magnetic resonance can be a suitable guide to cardiac management in TI, as well as in TM; TI patients show lower myocardial iron burden and more pronounced high cardiac output findings than TM patients. Moreover, it is proposed that, due to its good positive predictive value (PPV) and low cost, ECG can be a suitable guide to orient towards CMR examination in TM cases.Hemoglobin 02/2008; 32(1-2):97-107. · 1.30 Impact Factor -
Article: 2061 Delayed-enhancement in hypertrophic cardiomyopathy is linked to a low coronary sinus flow independently from the left ventricular mass
Journal of Cardiovascular Magnetic Resonance. 01/2008;
Top co-authors
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Institutions
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2008–2012
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National Research Council
- Institute of Clinical Physiology IFC
Roma, Latium, Italy
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2011
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John Paul II Institute
Saint Paul, MN, USA -
Istituto di Fisiologia Clinica del CNR
Pisa, Tuscany, Italy
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