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Publications (5)0 Total impact

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    ABSTRACT: Objective: The primary goal of this study is to evaluate predictors of nodular goiter in Graves Disease (GD).Materials and Methods: A total of 202 consecutive patients (mean age: 45; 145 female, 57 male) were enrolled. All patients were treated with antithyroid drugs as initial therapy. TSH, FT3, FT4, TRAb, ATPO, and ATG were measured. Radioactive iodine uptake and thyroid ultrasonography were performed, and thyroid volume and nodule diameter were assessed. Ultrasound-guided fine needle aspiration was performed on thyroid nodules ≥8mm. Results: Diffuse goiter was detected in 51% of patients. Solitary nodules were detected in 16%, and multi-nodular disease in 33%. Mean nodule diameter was 8.82 mm. Nodular disease was slightly more common in women (p=0.063). Patients with nodular GD were older (p=0.004), had lower levels of FT3 (p=0.016) and TRAB (p=0.002) when compared with subjects with diffuse GD. Age (OR:6.867) was the independent variable predicting nodular GD. Conclusion: Increased prevalence of nodules was associated with advanced age and milder thyrotoxicosis. Apoptosis of thyroid follicular cells due to excess iodine might interfere with nodule formation, and lead to diffuse goiter in severe thyrotoxicosis. Because of increased rate if malignancy in GD, comprehensive evaluation of thyroid nodules of any size is mandatory. Turk Jem 2009; 13: 1-4
    Turkish Journal of Endocrinology and Metabolism. 01/2009;
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    ABSTRACT: We describe a female patient who presented with Graves disease and a neck mass. Radiological characteristics of the mass suggested thymic hyperplasia. She was treated with methimazole, and because the mass did not regress after six months of therapy, the patient had total thyroidectomy and thymectomy. Pathological examination was consistent with chronic lymphocytic thyroiditis and thymic hyperplasia. Microscopic changes in the thymus can be detected in one third of patients with Graves disease, but massive enlargement is rare. It has been reported that regression occurs in most patients after a euthyroid state has been achieved; however, in some patients, thymectomy may be indicated. Turk Jem 2009; 13: 11-2
    Turkish Journal of Endocrinology and Metabolism. 01/2009;
  • Akıncı Barış, Çömlekçi Abdurrahman, Yener Serkan, Men Süleyman
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    ABSTRACT: Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) which may predominantly develop in pediatric cases during the management of DKA.. Symptomatic cerebral edema in children is rarely detected at admission, before initiation of the treatment. Cerebral edema associated with DKA is extremely rare in adults. Here, we report an adult patient with DKA who presented with symptomatic cerebral edema. Turk Jem 2009; 13: 16-8
    Turkish Journal of Endocrinology and Metabolism. 01/2009;
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    ABSTRACT: Objective: Erectile dysfunction (ED) is a commonly encountered complaint among chronic renal failure (CRF) patients. Uremia, psychogenic factors, neuroendocrinologic disturbances, and atherosclerosis are known etiologic factors that lead to ED in CRF patients. The purpose of the current prospective study was to evaluate clinical properties and laboratory findings that are associated with ED in non-diabetic CRF patients undergoing hemodialysis treatment.Materials and methods: Male non-diabetic patients with ED undergoing hemodialysis treatment were included in the study. Erectile and sexual functions were evaluated using the International Index of Erectile Function (IIEF) questionnaire. BUN, creatinine, complete blood count, fasting blood glucose, and lipid levels of all subjects were determined. Penile Doppler ultrasonography (PDU) was performed after intracavernosal injection of 50 mg papaverine HCl.Results: A total of 28 patients were enrolled in the study. Mean age and IIEF-EF domain scores of the patients was 50.5±10.3 years and 8.5±6.7, respectively. In the correlation analysis, there was a negative correlation between age and all domains of the IIEF (erectile function, EF: p<0.01, r=-0.724; orgasmic function, OF: p<0.01, r=-0.560; sexual desire, SD: p<0.05, r=-0.445; overall satisfaction, OS: p<0.05, r=-0.391 and intercourse satisfaction, IS: p<0.05, r=-0.455). Peak systolic velocities in PDU at 5, 10, and 20 min were also correlated with age (p=0.012, r=-0.428; p=0.008, r=-0.448; and p=0.009, r=-0.447, respectively). Erectile and sexual functions were significantly better in patiens ≤50 years.Conclusion: In hemodialysis patients, age is a major risk factor for ED development. Increasing age may contribute to ED through age-related damage in penile vascular structures.
    Turkish Journal of Urology. 01/2009;
  • Akıncı Barış, Çömlekçi Abdurrahman
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    ABSTRACT: Gynecomastia is the development of abnormal breast tissue in men. Relatively increased estrogen action on tissue level is believed to play a main role in the pathogenesis of the entity. Here, we describe a patient with painless gynecomastia presenting after cytotoxic chemotherapy for testicular cancer. Further investigations showed no evidence of disease progression, recurrence, or metastasis. We suggest that the clinicians should be aware that gynecomastia may follow cytotoxic chemotherapy for testicular cancer and does not reflect the return of malignancy. Turk Jem 2008; 12: 86-7
    Turkish Journal of Endocrinology and Metabolism. 01/2008;