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ABSTRACT: To demonstrate the utility of a "reduced field-of-view" (zoom imaging) technique to accelerate free-breathing, ECG-triggered, turbo-spin-echo black-blood sequences, which have been previously described to detect subclinical aortic atherosclerosis.
Fifteen healthy volunteers underwent MRI of the thoracic and abdominal aorta. Imaging with the conventional full field-of-view sequence was compared with zoom imaging. Total scan time, image quality (i.e., contrast-to-noise ratio and vessel wall sharpness) and vessel wall thickness were analyzed. A subgroup of 10 volunteers also underwent acceleration of imaging using sensitivity encoding (SENSE) for comparison.
Zoom imaging significantly reduced imaging time from a mean of 41 ± 9 min (conventional imaging) to 15 ± 0.5 min (P<0.01). There was no difference in image quality between conventional and zoom imaging with respect to CNR (10.1 ± 6 versus 10.1 ± 6) or vessel wall sharpness (38 ± 4% versus 39 ± 4%). Furthermore, Bland Altman plots showed excellent agreement in vessel wall thickness measurements using the two methods. In comparison, SENSE not only reduced CNR but also resulted in underestimation of vessel wall thickness compared with the conventional sequence.
Zoom imaging allows accurate and time-efficient imaging of the abdominal and thoracic aorta for cardiovascular risk prediction. In this application, it is preferable to SENSE.
Journal of Magnetic Resonance Imaging 08/2011; 34(2):279-85. · 2.70 Impact Factor
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Christian von Bary, Marcus Makowski,
Anne Preissel,
Alexandra Keithahn,
Alice Warley,
Elmar Spuentrup,
Arno Buecker,
Joel Lazewatsky,
Richard Cesati,
David Onthank,
Nikolaus Schickl,
Sylvia Schachoff,
Jörg Hausleiter,
Albert Schömig,
Markus Schwaiger,
Simon Robinson,
René Botnar
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ABSTRACT: The extracellular matrix (ECM) plays an important role in the pathogenesis of atherosclerosis and in-stent restenosis. Elastin is an essential component of the ECM. ECM degradation can lead to plaque destabilization, whereas enhanced synthesis typically leads to vessel wall remodeling resulting in arterial stenosis or in-stent restenosis after stent implantation. The objective of this study was to demonstrate the feasibility of MRI of vascular remodeling using a novel elastin-binding contrast agent (BMS-753951).
Coronary injury was induced in 6 pigs by endothelial denudation and stent placement. At day 28, delayed-enhancement MRI coronary vessel wall imaging was performed before and after injection of gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA). Two days later, DE-MRI was repeated after administration of BMS-753951. Contrast-to-noise-ratio and areas of enhancement were determined. Delayed-enhancement MRI with BMS-753951 caused strong enhancement of the aortic, pulmonary artery, and injured coronary artery walls, whereas Gd-DTPA did not. Delayed-enhancement MRI of the stented coronary artery with BMS-753951 yielded a 3-fold higher contrast-to-noise-ratio when compared with the balloon-injured and control coronary artery (21±6 versus 7±3 versus 6±4; P<0.001). The area of enhancement correlated well with the area of remodeling obtained from histological data (R(2)=0.86, P<0.05).
We demonstrate the noninvasive detection and quantification of vascular remodeling in an animal model of coronary vessel wall injury using an elastin-specific MR contrast agent. This novel approach may be useful for the assessment of coronary vessel wall remodeling in patients with suspected coronary artery disease. Further studies in atherosclerotic animal models and degenerative ECM disease are now warranted.
Circulation Cardiovascular Imaging 03/2011; 4(2):147-55. · 5.94 Impact Factor
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ABSTRACT: First-pass contrast-enhanced myocardial perfusion MRI in rodents has so far not been possible due to the temporal and spatial resolution requirements. We developed a new first-pass perfusion MR method for rodent imaging on a clinical 3.0-T scanner (Philips Healthcare, Best, The Netherlands) that employed 10-fold k-space and time domain undersampling with constrained image reconstruction, using temporal basis sets (k-t principle component analysis) to achieve a spatial resolution of 0.2 × 0.2 × 1.5mm(3) and an acquisition window of 43 msec. The method was successfully tested in five healthy and four infarcted mice (C57BL/6J) at heart rates of 495.1 ± 45.8 beats/min. Signal-intensity-time profiles showed a percentage myocardial signal increase of 141.3 ± 38.9% in normal mice, compared with 44.7 ± 32.4% in infarcted segments. Mean myocardial blood flow by Fermi function for constrained deconvolution in control mice was 7.3 ± 1.5 mL/g/min, comparable to published literature, with no significant differences between three myocardial segments. In infarcted segments, myocardial blood flow was significantly reduced to 1.2 ± 0.8 mL/g/min (P < 0.01). This is the first report of first-pass myocardial perfusion MR in a mouse model on a clinical 3-T MR scanner and using a k-t undersampling method. Data were acquired on a 3-T scanner, using an approach similar to clinical acquisition protocols, thus facilitating translation of imaging findings between rodent and human studies.
Magnetic Resonance in Medicine 10/2010; 64(6):1592-8. · 2.96 Impact Factor
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Journal of Cardiovascular Magnetic Resonance. 01/2010;
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Journal of Cardiovascular Magnetic Resonance. 01/2010;
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Christian Jansen,
Divaka Perera, Marcus Makowski,
Andrea Wiethoff,
Andreas Schuster,
Timothy Lockie,
Reza Razavi,
Gerald Greil,
Eike Nagel,
Simon Redwood,
Rene Botnar
Journal of Cardiovascular Magnetic Resonance. 01/2010;
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Christian Jansen,
Divaka Perera, Marcus Makowski,
Andrea Wiethoff,
Kalpa Desilva,
Amedeo Chiribiri,
Andreas Indermuehle,
Reza Razavi,
Gerald Greil,
Eike Nagel,
Simon Redwood,
Rene Botnar
Journal of Cardiovascular Magnetic Resonance. 01/2010;
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Marcus Makowski,
Andrea Wiethoff,
Vicky Parish,
Aaron Bell,
Rene Botnar,
Christian Jansen,
Sergio Uribe,
Martin Rohrer,
Reza Razavi,
Tobias Schaeffter,
Gerald Greil
Journal of Cardiovascular Magnetic Resonance. 01/2009;
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Gerald Greil, Marcus Makowski,
Andrea Wiethoff,
Vicky Parish,
Sergio Uribe,
Christian Jansen,
Aaron Bell,
Phillip Beerbaum,
Martin Rohrer,
Rene Botnar,
Reza Razavi,
Tobias Schaeffter
Journal of Cardiovascular Magnetic Resonance. 01/2009;
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Matthias Sausbier,
Usamah Abdullah,
Ulrike Sausbier,
Yi-Liu Liao,
Hong Zhao, Marcus Makowski,
Susanne Feil,
Robert Feil,
Franz Hofmann,
Alfred Nordheim,
René Botnar,
Peter Ruth
BMC Pharmacology. 01/2009;
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von Bary Christian,
Anne Preissel,
Susanne Wagner, Marcus Makowski,
Alexandra Keithahn,
Elmar Spuentrup,
Albert Schoemig,
Simon Robinson,
Joel Lazewatsky,
Markus Schwaiger,
Joerg Hausleiter,
Matthias Taupitz,
René Botnar
Journal of Cardiovascular Magnetic Resonance. 01/2008;
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Journal of Cardiovascular Magnetic Resonance. 01/2008;
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Journal of Cardiovascular Magnetic Resonance. 01/2008;
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Journal of Cardiovascular Magnetic Resonance. 01/2008;
