Debabrata Basu

Central Glass and Ceramics Research Institute, Kolkata, Bengal, India

Are you Debabrata Basu?

Claim your profile

Publications (87)80.44 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Yttria—partially stabilized zirconia (Y—PSZ) ceramics containing 3.5, 4.0 and 5.0 mol% Y2O3 were fabricated from commercial grade zirconia powder by dry pressing and normal sintering at 1600°C. The mechanical properties and microstructures of such materials were examined. Mechanical properties, both strength and fracture toughness, deteriorated with increasing yttria content. XRD revealed the presence of both tetragonal and monoclinic phases in the sintered materials and with decreasing yttria content, the tetragonal phase increased. Vickers' microhardness values differed slightly among the three compositions.
    Transactions - Indian Ceramic Society 03/2014; 51(3):60-62. · 0.13 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In recent years polycrystalline alumina ceramics have been widely used as bioceramic implants in various orthopaedic applications in western countries. Alumina ceramics have been proved to be more biocompatible, resistant to corrosion and abrasion over conventional metals and, therefore, higher durability of the implants is envisaged.
    Transactions - Indian Ceramic Society 03/2014; 53(5):123-126. · 0.13 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Polycrystalline diamond (PCD) films have been grown over 100 mm diameter silicon (100) substrate, using microwave plasma chemical vapour deposition (MPCVD) technique. The deposition was carried out inside a 15 cm diameter quartz chamber with microwave power of 15 kW at 915 MHz frequency. Uniform substrate surface temperature of 1050°C with plasma heating was maintained with simultaneous cooling arrangement. The pressure was 110 Torr and the microwave incident power was 8.5 kW. Temperature uniformity and plasma geometry over the substrate are the key parameters for producing uniformly thick MPCVD diamond films of high quality. Thickness uniformity of as-deposited films is ±10% across 100 mm diameters with a growth rate of 1 µm.h–1. The grown PCD was characterized by X-ray diffractometry (XRD), Raman spectrometry, field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), transmission electron microscopy (TEM) and bright field imaging technique. Experimental results indicate columnar growth of a very densely crystalline PCD with (111) facets of high quality morphology.
    Transactions - Indian Ceramic Society 12/2013; 72(4):225-232. · 0.13 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Chronic osteomyelitis is a challenging setback to the orthopedic surgeons in deciding an optimal therapeutic strategy. Conversely, patients feel frustrated of the therapeutic outcomes and development of adverse drug effects, if any. Present investigation deals with extensive approach incorporating in vivo animal experimentation and human application to treat chronic osteomyelitis, using antibiotic loaded porous hydroxyapatite scaffolds. Micro- to macro-porous hydroxyapatite scaffolds impregnated with antibiotic ceftriaxone-sulbactam sodium (CFS) were fabricated and subsequently evaluated by in vivo animal model after developing osteomyelitis in rabbit tibia. Finally 10 nos. of human osteomyelitis patients involving long bone and mandible were studied for histopathology, radiology, pus culture, 3D CT etc. up to 8-18months post-operatively. It was established up to animal trial stage that 50N50H samples [with 50-55% porosity, average pore size 110μm, higher interconnectivity (10-100μm), and moderately high drug adsorption efficiency (50%)] showed efficient drug release up to 42days than parenteral group based on infection eradication and new bone formation. In vivo human bone showed gradual evidence of new bone formation and fracture union with organized callus without recurrence of infection even after 8months. This may be a new, alternative, cost effective and ideal therapeutic strategy for chronic osteomyelitis treatment in human patients.
    Materials science & engineering. C, Materials for biological applications. 10/2013; 33(7):3986-93.
  • Samit K Nandi, Biswanath Kundu, Debabrata Basu
    [Show abstract] [Hide abstract]
    ABSTRACT: Present study aimed to investigate and compare effectiveness of porous chitosan alone and in combination with insulin like growth factor-1 (IGF-1) and bone morphogenetic protein-2 (BMP-2) in bone healing. Highly porous (85±2%) with wide distribution of macroporous (70-900μm) chitosan scaffolds were fabricated as bone substitutes by employing a simple liquid hardening method using 2% (w/v) chitosan suspension. IGF-1 and BMP-2 were infiltrated using vacuum infiltration with freeze drying method. Adsorption efficiency was found to be 87±2 and 90±2% for BMP-2 and IGF-1 respectively. After thorough material characterization (pore details, FTIR and SEM), samples were used for subsequent in vivo animal trial. Eighteen rabbit models were used to evaluate and compare control (chitosan) (group A), chitosan with IGF-1 (group B) and chitosan with BMP-2 (group C) in the repair of critical size bone defect in tibia. Radiologically, there was evidence of radiodensity in defect area from 60th day (initiated on 30th day) in groups B and C as compared to group A and attaining nearly bony density in most of the part at day 90. Histological results depicted well developed osteoblastic proliferation around haversian canal along with proliferating fibroblast, vascularization and reticular network which was more pronounced in group B followed by groups C and A. Fluorochrome labeling and SEM studies in all groups showed similar outcome. Hence, porous chitosan alone and in combination with growth factors (GFs) can be successfully used for bone defect healing with slight advantage of IGF-1 in chitosan samples.
    Materials science & engineering. C, Materials for biological applications. 04/2013; 33(3):1267-75.
  • Biswanath Kundu, Dipayan Sanyal, Debabrata Basu
    [Show abstract] [Hide abstract]
    ABSTRACT: Hydroxyapatite (HAp)-based highly porous integrated orbital implants with a property of mimicking the movements of fellow eye have been developed recently. Before designing this kind of scaffolds, vascularization and angiogenesis in the constructs need to be considered. Moreover, eye cells expressed with time on these highly porous implants may exert some compressive load whose effect both mechanically and physiologically may indicate its long-term life in vivo. In the present investigation the effect of expression of eye cell lines [rabbit corneal epithelial cell line (SIRC)] on highly porous HAp scaffolds were compared with the normal fibroblastic cells on HAp in general, in terms of in vitro dissolution studies, cell culture cytotoxicity and cell adhesion properties. Elastic properties of macro-porous HAp with a wide range of porosities have also been estimated by ultrasonic non-destructive test methods and the results were compared with its compressive properties for potential application as integrated ocular implants. Cell viability of HAp in contact with SIRC is far better than the L-929 during the initial periods (48 h) but cell adhesion behavior however showed better results in L-929 than the SIRC during the same initial time period. SIRC cells however eventually formed better adhesion properties on the surface of HAp as the days goes by than L-929. High concentration of both Ca and P in culture media might be another factor in cell growth modification. Both the ions had a counter effect on the L-929 and SIRC cells.
    Ceramics International. 04/2013; 39(3):2651–2664.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Freestanding polycrystalline diamond (PCD) coatings are of immense technological importance. PCD has been grown over silicon substrates by microwave plasma assisted chemical vapor deposition (MWPACVD) process. The coatings are grown by suitable optimisation of the growth parameters of a 915 MHz microwave reactor. Thereafter, 1:1:1 solution of hydrofluoric acid (HF), nitric acid (HNO 3) and acetic acid (CH 3 COOH) is used to etch out the silicon wafer from the backside of the coating. Hereby, freshly generated nucleation surface, could be characterised by scanning electron microscopy (SEM), atomic force microscopy (AFM), Raman spectroscopy and stylus profilometer and could be compared with the growth side. It is found that both the nucleation side and growth side are of very high quality (full width at half maxima, i.e., FWHM < 8 cm -1). The growth side is (111) textured, whereas, the nucleation side is very smooth with embedded detonation-nano-diamond (DND) agglomerates. These freestanding coatings are successfully laser cut into different geometrical shapes. They are found to be optically translucent having high refractive index. Cross-sectional microscopy of the laser cut edge reveals novel melting features of the CVD grown diamond columns. Free-standing diamond films over large area are technologically very important for many applications due to their unique mechanical, optical, electrical and thermal properties. These free-standing films, either in plate form or in foil form, have to be smooth, and chemically clean with low residual stress and considerable thickness uniformity 1-6 . They can be brazed to a supporting frame or may be free standing as per the end applications, like Gyrotron windows, supporting rods for helix transmission wave tubes (TWTs), x-ray optics, thermal management etc. (Table 1) 7-9 . The thicknesses of these free standing films may vary from few nanometres to few millimetres, depending on the end use and can be up to 300 mm in diameter. Synthesis of Freestanding Diamond Presently, the most sought after method to prepare free-standing diamond film is the microwave plasma chemical vapor deposition (MPCVD) technique. Diamond films are deposited on carbide-forming substrates like Si, Mo, and Ta by MPCVD. Now to make the deposited coating freestanding, films are to be separated from the substrate by chemical etching or mechanical peeling 1-6,10 . Fan et al. 10 deposited PCD by two-step microwave plasma CVD process on copper substrates to overcome film cracking due to thermal mismatch between the substrate and the film. The coating naturally peeled off during first step of cooling down from higher temperature, thus delaminating the PCD film, over which, further crack-free PCD growth occurs in the subsequent step. Further, the authors characterised both the growth side and the nucleation side of such freestanding films. Lee et al. 11 also adopted similar principle of multiple-step CVD growth. They decreased the growth temperature by 10°C each after 24 h and had thermal gradient cooling after completion of deposition and thereby avoided growth cracks in the freestanding films 11-13
    01/2013;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The tuning (optimization) of the reactor parameters is very important in order to achieve spatial temperature uniformity across the large area substrate for growing high quality and uniformly thick diamond coatings. It is also important to minimize the thermal stress, arising from temperature non-uniformity, for producing crack free large area diamond coatings. So by varying different process parameters, such as chamber pressure, microwave power, gas flow rate and cavity lengths (by changing the probe, short and stage positions), the resultant variation of substrate surface temperature can be measured. By tuning these parameters the geometry as well as the density of the plasma discharge which directly influences substrate surface temperature may be controlled. It has been shown that by suitable manipulation of the reactor parameters one could achieve at best 80 °C variation in temperature uniformity over 100 mm diameter, which indeed has resulted in a very uniformly thick (± 12.8%) high quality polycrystalline diamond (PCD) coating.
    Diamond and Related Materials 11/2012; 30:53–61. · 1.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Two different varieties of Si3N4 powders were used to prepare SiAlON ceramics. 100% β-Si3N4 was used from refractory grade powders (B1) and another purer 98% α-Si3N4 (50A) powder was used to prepare the SiAlON samples. Since SiC + SiAlON composites reportedly perform better, batches were prepared with 15% SiC addition to the refractory powders (B1) and 17.5% SiC was added to the other SiAlON composition (50A). The samples were gas pressure sintered at 1840 °C and at 22 bar with 1 h dwelling time. Thereby, we could achieve 97–98% theoretical density. The hardness was recorded 14–17 GPa while fracture toughness varied from 4.3 to 5 MPa m1/2. Fretting experiments showed initial running-in period of 300 cycles for all the tribo-couples. After which, the steady state coefficient of frictions (COF) were achieved. Steel ball of 10 mm diameter, fretting against 50A composition, showed 0.6 average steady state COF while the same composition while fretting against alumina ball of the same diameter, showed 0.57 average steady state COF. Results have been compared with SiAlON composition derived from refractory powder (B1) and found that the 50A composition performs better under identical test conditions. Moreover, cytocompatibility study also suggests that the investigated 50A composition can be used as substrate to support cell adhesion and proliferation of L929 mouse fibroblast cell lines whereas B1 composition derived from refractory powders are toxic in nature.
    Ceramics International. 09/2012; 38(7):5757–5767.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Several synthetic alloplastic materials have been used in the past as an implant in infrabony defects with a goal to reconstruct the lost part of attachment apparatus via new osseous tissue formation. The present study was undertaken to evaluate and compare clinico-radiographically, the effect of bioactive glass (BG), hydroxyapatite (HA), and BG-HA composite bone graft particles in the treatment of human infra-bony periodontal defects. Indigenous synthetic HA, BG, and BG-HA composite bone graft materials were developed in the laboratory. Twenty eight infrabony periodontal defects were equally distributed (i.e., seven defects) into four groups. The defects were treated separately with three types of graft materials and non-grafted manner (open flap debridement alone, control) to evaluate both the soft and hard tissue responses after six months of surgery. Evaluation was done by studying different parameters such as plaque index, gingival index, relative attachment level, probing pocket depth, and radiographic bone fill in Intra Oral Peri-Apical radiograph. The healing of defects was uneventful and free of any biological complications. The gain in relative attachment level, reduction of probing pocket depth, and bone fill was statistically significant in all four groups. BG and BG-HA synthetic bone graft implanted sites showed significant bone fill (P<0.05) than hydroxyapatite and unimplanted control sites. The performance of BG and its composite was better compared to HA and open flap debridement alone for the reconstruction of infrabony defects. The BG-HA composite particles may effectively be used as an alternative bone graft material for infrabony defects.
    Journal of Indian Society of Periodontology 04/2012; 16(2):241-6.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON–SiC composites with varying amount of SiC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives.
    Materials Science and Engineering C 04/2012; 32(3):464-469. · 2.40 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Present investigation deals with in vitro and in vivo experimentation to treat chronic osteomyelitis, using pure β-tri calcium phosphate porous scaffolds. A novel approach was given to treat such infections using the scaffolds and drug combinations consisting of ideal antibiotics. In vitro studies include variation of porosity with interconnectivity, pore-drug interfacial studies by SEM-EDAX and drug elution studies both in contact with PBS and SBF at ca. 37°C. In vivo trials were based on experimental osteomyelitis in rabbit model in tibia by Staphylococcus aureus. Characterizations included histopathology, radiology and estimation of drug in both bone and serum for 42 days by HPLC and subsequent bone–biomaterial interface by SEM. Samples having 60–65% porosity with average pore size ca. 55μm and higher interconnectivity (22–113μm), high adsorption efficiency (ca. 79%) of drug showed prolonged, sustained release of the drugs considered being sufficient to treat chronic osteomyelitis with desirable bone formation.
    Ceramics International - CERAM INT. 03/2012;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Mg–Al layered double hydroxide nanopowders were synthesised by a facile coprecipitation technique at different pH conditions. LDH nanoparticles of higher aspect ratio with an average particle size of 26nm were obtained at pH 9 whereas a pH of 11.3 resulted in LDH nanoparticles of average size 50nm with lower aspect ratio and narrower size distribution. LDH–MTX organo–inorganic nanohybrid was produced with an average particle size of 53nm after intercalation of MTX into the interlayer space of LDH, as evident from the shift of (003) peak in X-ray diffraction. This was corroborated by the transmission electron micrograph, which showed an increase in average interlayer spacing from 8.00Å in pristine LDH to 21.4Å in LDH–MTX nanohybrid. Thermogravimetric analyses showed ∼33.2wt% MTX loading in the LDH structure. The MTX release profile from Mg–Al LDH–MTX nanohybrid in phosphate buffer saline at pH 7.4 follows Ritger–Peppas kinetics model which demonstrates that the release kinetics is diffusion controlled. An attempt has been made to explain the above observations based on the effect of electrical double layer repulsions on the growth of LDH nuclei, primarily considering significance of the particle morphology in drug delivery application.
    Ceramics International - CERAM INT. 03/2012;
  • [Show abstract] [Hide abstract]
    ABSTRACT: The present study aims to develop suitable advanced potting material for modern high performance dispenser cathodes for high power microwave tube through refinement of the alumina microstructure by using suitable dopant. Calcium Oxide was selected as a dopant material and the resultant materials were characterized by X-ray diffraction studies and the microstructure monitored by SEM study and EDX analysis. The shrinkage, thermal and electrical properties of the resultant material was evaluated to establish its suitability to function as an advanced potting material
    Materials Science and Engineering B-advanced Functional Solid-state Materials. 02/2012;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Active metal brazing of alumina with alumina, graphite and monel 404 superalloy was performed at 910°C for 5min using TICUSIL (68.8Ag–26.7Cu–4.5Ti in wt.%) as the braze alloy in vacuum of 5×10−6mbar. The brazed joints were characterized by X-ray diffraction, scanning electron microscopy, energy dispersive X-ray analysis, nanohardness and Young's modulus measurements by depth sensitive indentation technique. X-ray diffractrometry showed that the Ti-based compounds were formed at the substrate–filler alloy interfaces of the brazed joints as reaction products. The cross sectional microstructures of the brazed joints were observed by scanning electron microscopy. The energy dispersive X-ray analysis determined the elemental compositions at the selective points of the joint cross section, which supported the X-ray diffraction results. The nanohardness and Young's modulus of the substrate–filler alloy interface showed no abrupt change, which suggests reliable joint performance in service.
    Ceramics International - CERAM INT. 01/2012;
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: In situ synthesized TiB–TiN-reinforced Ti6Al4V alloy composite coatings were laser deposited on commercially pure Ti using premixed Ti6Al4V and BN powder. The amount of TiB/TiN was found to increase with increasing BN concentration and laser energy input. Due to the increase in the BN content from 5 to 15 wt.%, the top surface hardness and Young’s modulus increased from 543 to 877 HV and from 170 to 204 GPa, respectively, while the thickness of the coating varied from 467 to 1236 μm.
    Scripta Materialia 01/2012; 66(8):578 - 581. · 2.82 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: The use of different bioactive materials as coating on dental implant to restore tooth function is a growing trend in modern Dentistry. In the present study, hydroxyapatite and the bioactive glass-coated implants were evaluated for their behavior in osseous tissue following implantation in 14 patients. Bioactive glass and hydroxyapatite formulated and prepared for coating on Ti-6Al-4V alloy. Hydroxyapatite coating was applied on the implant surface by air plasma spray technique and bioactive glass coating was applied by vitreous enameling technique. Their outcome was assessed after 6 months in vivo study in human. Hydroxyapatite and bioactive glass coating materials were nontoxic and biocompatible. Uneventful healing was observed with both types of implants. The results showed bioactive glass is a good alternative coating material for dental implant.
    Journal of Indian Society of Periodontology 07/2011; 15(3):215-20.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The present communication reports an interesting observation on stepwise development of crystallinity along with change in elemental composition of the HAp crystals, precipitated on SS 316L substrates (4mm×5mm×1mm) by biomimetic route. The SS 316L substrates were incubated up to 6 days in simulated body fluid (SBF) at 37°C with a periodic replacement of freshly prepared SBF at 48h intervals. X ray diffraction (XRD) analysis of coated substrates revealed phase pure hydroxyapatite (HAp) as the only phase present in the coating. Transmission electron microscopy (TEM) images of the coating showed a gradual transformation of core shell type spherical HAp crystal into elongated forms over a period of 6 days of incubation of SS 316L substrate in SBF. The elemental composition of the deposited HAp phase was also changed with increase in exposure time of SS 316L to SBF as indicated by the energy dispersive spectra (EDS) of coated substrates.
    Journal of the Taiwan Institute of Chemical Engineers 06/2011; 42(4):682-687. · 2.08 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Current trends in clinical dental implant therapy include modification of titanium surfaces for the purpose of improving osseointegration by different additive (bioactive coatings) and subtractive processes (acid etching, grit-blasting). The aim of this study was to evaluate and compare the behaviour of hydroxyapatite and the newly developed bioactive glass coated implants (62 implants) in osseous tissue following implantation in 31 patients. Bioactive glass and hydroxyapatite was suitably coated on titanium alloy. Hydroxyapatite coating was applied on the implant surface by air microplasma spray technique and bioactive glass coating was applied by vitreous enamelling technique. The outcome was assessed up to 12 months after prosthetic loading using different clinical and radiological parameters. Hydroxyapatite and bioactive glass coating materials were non-toxic and biocompatible. Overall results showed that bioactive glass coated implants were as equally successful as hydroxyapatite in achieving osseointegration and supporting final restorations. The newly developed bioactive glass is a good alternative coating material for dental implants.
    Australian Dental Journal 03/2011; 56(1):68-75. · 1.37 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Multiwall carbon nanotube (CNT) reinforced Cu–10Snalloycomposites were fabricated using high power lasers. Microstructural observations showed that CNTs were retained in the composite matrix after laser processing. The addition of CNTs showed improvement in strain hardening, mechanical and thermal properties of Cu–10Snalloy. Composites with 12 vol.% CNTs showed more than 80% increase in the Young's modulus and 40% increase in the thermal conductivity of Cu–10Snalloy. Yield strength estimates using a model based on strengthening mechanisms in metal matrix nanocomposites and thermal conductivities derived from the Maxwell–Garnett effective medium theory were found to be in good agreement with our experimental data.
    Materials Science and Engineering: A. 01/2011; 528:6727-6732.

Publication Stats

370 Citations
80.44 Total Impact Points

Institutions

  • 1991–2014
    • Central Glass and Ceramics Research Institute
      Kolkata, Bengal, India
  • 2008–2013
    • West Bengal University of Animal and Fishery Sciences
      • Department of Veterinary Surgery and Radiology
      Calcutta, Bengal, India
  • 2011–2012
    • Dr. R. Ahmed Dental College and Hospital
      Kolkata, Bengal, India
  • 1996–2008
    • Jadavpur University
      • Department of Metallurgical and Material Engineering
      Calcutta, Bengal, India