C. Taubner
Technische Universität Braunschweig, Braunschweig, Lower Saxony, Germany

Are you C. Taubner?

Claim your profile

Publications (2)0 Total impact

  • Conference Proceeding: Modelling and Simulation of the TLR4 Pathway with Coloured Petri Nets
    C. Taubner, B. Mathiak, A. Kupfer, N. Fleischer, S. Eckstein
    [show abstract] [hide abstract]
    ABSTRACT: This paper demonstrates the first steps of an automation process to develop models of signal transduction pathways using discrete modelling languages. The whole approach consists of modelling, validation, animation, linking databases to simulation tools and also the qualitative analysis of the data. In this paper, we detail the modelling and simulation of the TLR4 pathway with a coloured petri net simulation tool and the validation of this model against the semantic and mechanistic map from a biological database. These graphical maps contain all necessary reactions as a figure. We start with an UML class diagram to understand the static structure of molecules involved in the TLR4 pathway. Afterwards we model and simulate each "pathway step reaction" - one after another - to get the behaviour of the final system. The result is a model of the pathway which can be used in simulations, derived solely from basic chemical reactions in the database. Also, it is a lesson on critical points where human decision-making is needed, because not all the required information is stored directly in the database
    Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE; 10/2006
  • Source
    Conference Proceeding: Discrete Modelling of the Ethylene-Pathway
    C. Taubner, T. Merker
    [show abstract] [hide abstract]
    ABSTRACT: Arabidopsis thaliana is a small flowering plant that is widely used as a model organism in plant biology. We describe here the Ethylene-Response Pathway (Ethylene- Pathway) whose is belong to the signal transduction pathways. The knowledge of the signaling pathways are still incomplete and discrete modelling has been shown to help a better understanding of the underlying mechanisms. In this paper we provide a brief introduction to the Ethylene- Pathway and describe two approaches - UML-Statecharts and Life Sequence Charts (LSC) - in discrete modelling of the signaling pathway.
    Data Engineering Workshops, 2005. 21st International Conference on; 05/2005

Institutions

  • 2005–2006
    • Technische Universität Braunschweig
      Braunschweig, Lower Saxony, Germany
Browse more researchers