Publications (5)22.38 Total impact
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Article: Metallic taste after coronary artery stent implantation.
International journal of cardiology 11/2011; 158(2):e30-1. · 7.08 Impact Factor -
Article: Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results from the ARMYDA-6 MI (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Myocardial Infarction) randomized study.
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ABSTRACT: The purpose of this study was to compare 600- and 300-mg clopidogrel loading doses in patients with ST-segment elevation myocardial infarction (STEMI). Given the high thrombotic risk of patients with STEMI, greater platelet inhibition may improve outcome in those patients receiving percutaneous coronary intervention (PCI). Although observational data suggest that pretreatment with a 600-mg clopidogrel loading dose may be more effective than the 300-mg regimen in primary PCI, this hypothesis has never been tested in a randomized study. A total of 201 patients undergoing primary PCI for STEMI randomly received a 600-mg (n = 103) or 300-mg (n = 98) clopidogrel loading dose before the procedure. The primary endpoint was the evaluation of the infarct size, defined as the area under the curve of cardiac markers. Infarct size was significantly lower in the high-dose regimen: median creatine kinase-myocardial band 2,070 ng/ml (interquartile range [IQR]: 815 to 2,847 ng/ml) versus 3,049 ng/ml (IQR: 1,050 to 7,031 ng/ml) in the 300-mg group, p = 0.0001; troponin-I 255 ng/ml (IQR: 130 to 461 ng/ml) versus 380 ng/ml (IQR: 134 to 1,406 ng/ml), p < 0.0001. In the 600-mg arm, Thrombolysis In Myocardial Infarction flow grade <3 after PCI was less frequent (5.8% vs. 16.3%, p = 0.031), left ventricular ejection fraction at discharge was improved (52.1 ± 9.5% vs. 48.8 ± 11.3%, p = 0.026), 30-day major adverse cardiovascular events were fewer (5.8% vs. 15%, p = 0.049), and bleeding/entry site complications were not increased (secondary endpoints). In STEMI patients, pre-treatment with a 600-mg clopidogrel loading dose before primary PCI was associated with a reduction of the infarct size compared with a 300-mg loading dose, as well as with improvement of angiographic results, residual cardiac function, and 30-day major adverse cardiovascular events; further studies are warranted to evaluate impact of such strategy on survival.Journal of the American College of Cardiology 10/2011; 58(15):1592-9. · 14.16 Impact Factor -
Article: [Secondary prevention of patients with ischaemic heart disease--the reduction of LDL cholesterol level and the regression of atherosclerosis].
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ABSTRACT: The authors review the options of secondary medical prevention in patients with ischaemic heart disease, stressing the need and safety of using statins. The beneficial effect of statin therapy on cardiovascular morbidity and mortality and the clinical benefit of the greatest possible reduction in LDL cholesterol level are presented. The atherosclerotic plaque regression achieved by a high-intensity statin therapy in the ASTEROID trial is also briefly reviewed.Lege artis medicinae: új magyar orvosi hírmondó 11/2007; 17(10):675-9. -
Article: Arrhythmias of a sudden traumatic death.
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ABSTRACT: A 73-year-old man was treated because of his paroxysmal palpitations became persistent. At the time of hospital admission atrial flutter was found. Antiarrhythmic drug treatment was unsuccessful therefore electrical cardioversion was indicated which restored his sinus rhythm. After one year of uneventful follow up Holter monitoring was indicated again. When the machine was hooked up sinus rhythm was observed. After 53 minutes a tram knocked down the patient, and he died immediately. During autopsy brain laceration, multiple cranial fractions, mediastinal hemorrhage were found. The Holter recording time was 66 minutes. Before the accident sinus rhythm was recorded. At the time of accident an electrical noise was found, followed by long sinus arrest, atrial fibrillation, nodal escape rhythm, sinus bradycardia, ventricular flutter, tachycardia, fibrillation and "dying heart" rhythm. According to our knowledge this is the first Holter monitoring observation during a sudden traumatic death.Journal of Electrocardiology 08/2004; 37(3):227-30. · 1.14 Impact Factor -
Article: [Evaluation of fitness to drive--conclusions after a case report].
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ABSTRACT: Health evaluation of candidates applying driving license is general practitioner's duty, in the case of driving private cars. In Hungary no generally accepted guideline available on the evaluation process, the necessary examinations etc. A patient with a III degree A-V block was treated by the authors after suffering a serious syncope, with brain contusion, however he was regarded fit to drive by his GP, after the serious accident. The patient after the brain trauma was treated in two different institutions, however no ECG record was found, when the authors asked it to find out the time of the A-V block. Finally the patients was treated with temporary and later on with permanent pace-maker. During the half year follow up the patient was symptom less. The authors summarize the possible mechanism of syncope, and the criteria the evaluation of patients with heart diseases. In conclusion the authors emphasize the need for a generally accepted Hungarian guideline in the evaluation process of candidates applying driving license.Orvosi Hetilap 01/2003; 143(50):2781-4.
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2007
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Semmelweis University
Budapest, Budapest fovaros, Hungary
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