[show abstract][hide abstract] ABSTRACT: The development of microwave breast cancer detection and treatment techniques has been driven by reports of substantial contrast in the dielectric properties of malignant and normal breast tissues. However, definitive knowledge of the dielectric properties of normal and diseased breast tissues at microwave frequencies has been limited by gaps and discrepancies across previously published studies. To address these issues, we conducted a large-scale study to experimentally determine the ultrawideband microwave dielectric properties of a variety of normal, malignant and benign breast tissues, measured from 0.5 to 20 GHz using a precision open-ended coaxial probe. Previously, we reported the dielectric properties of normal breast tissue samples obtained from reduction surgeries. Here, we report the dielectric properties of normal (adipose, glandular and fibroconnective), malignant (invasive and non-invasive ductal and lobular carcinomas) and benign (fibroadenomas and cysts) breast tissue samples obtained from cancer surgeries. We fit a one-pole Cole-Cole model to the complex permittivity data set of each characterized sample. Our analyses show that the contrast in the microwave-frequency dielectric properties between malignant and normal adipose-dominated tissues in the breast is considerable, as large as 10:1, while the contrast in the microwave-frequency dielectric properties between malignant and normal glandular/fibroconnective tissues in the breast is no more than about 10%.
Physics in Medicine and Biology 11/2007; 52(20):6093-115. · 2.70 Impact Factor
[show abstract][hide abstract] ABSTRACT: The clinical efficacy of emerging microwave breast cancer detection and hyperthermia treatment techniques (see [X. Li et al., 2005], [M. Converse et al., 2004] and references therein) depend on the microwave dielectric properties of normal, malignant, and benign breast tissues. Knowledge of these properties has been limited by gaps and discrepancies in previously published small-scale studies reporting the dielectric properties of normal and malignant breast tissues obtained from cancer surgeries [L. Sha et al., 2002]. To address these limitations, we have conducted a large-scale joint study at the Universities of Wisconsin and Calgary to experimentally characterize the wideband dielectric properties at microwave frequencies (from 0.5 to 20 GHz) of freshly excised normal, benign, and malignant breast tissues obtained from breast reduction as well as cancer surgeries. In our presentation, we will highlight the conclusions from all aspects of our completed study. Due to space limitations in this conference paper summary, here we focus on the results of a comparison of the dielectric properties of normal breast tissues obtained from both reduction and cancer surgeries.
Antennas and Propagation Society International Symposium, 2007 IEEE; 07/2007