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ABSTRACT: The present study was conducted to investigate whether typical isoprenyl compounds (TICs) can control liposomal fusion reactions through changes in the physical properties of membranes. The fusion capabilities of TIC-incorporated liposomes were characterized by measuring the <sup>13</sup>C spin-lattice relaxation times (<sup>13</sup>CT<sub>1</sub>) and the gel permeation chromatogram (GPC) patterns. The <sup>13</sup>CT<sub>1</sub> relaxivities of some of these TlC-liposomes were remarkably enhanced at 27degC. The highest <sup>13</sup>CT<sub>1</sub> value obtained was for the beta-carotene-liposome, which ruptured, and was attributed to the highest membrane fusion reactivity. The other TIC-liposomes incorporated with alpha-tocopherol, canthax- nnlhin, or coenzyme Q<sub>10</sub> also induced significant fusion and did not rupture in comparison with the beta-carotene-liposome. These results show that the incorporations of TICs into lipid bilayers are useful to control liposomal nanocarriers for suitable membrane packing and advantageous phase separation, which could affect membrane-related processes.
IEEE Transactions on NanoBioscience 10/2007; · 1.29 Impact Factor