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Johanna T Dwyer,
Joanne Holden,
Karen Andrews,
Janet Roseland,
Cuiwei Zhao, Amy Schweitzer,
Charles R Perry,
James Harnly,
Wayne R Wolf,
Mary Frances Picciano, [......],
Elizabeth A Yetley,
Joseph M Betz,
Paul M Coates,
John A Milner,
Jackie Whitted,
Vicki Burt,
Kathy Radimer,
Jaime Wilger,
Katherine E Sharpless,
Constance J Hardy
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[hide abstract]
ABSTRACT: This article illustrates the importance of having analytical data on the vitamin and mineral contents of dietary supplements in nutrition studies, and describes efforts to develop an analytically validated dietary supplement ingredient database (DSID) by a consortium of federal agencies in the USA. Preliminary studies of multivitamin mineral supplements marketed in the USA that were analyzed as candidates for the DSID are summarized. Challenges are summarized, possible future directions are outlined, and some related programs at the Office of Dietary Supplements, National Institutes of Health are described. The DSID should be helpful to researchers in assessing relationships between intakes of vitamins and minerals and health outcomes.
Analytical and Bioanalytical Chemistry 10/2007; 389(1):37-46. · 3.78 Impact Factor
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Karen W Andrews, Amy Schweitzer,
Cuiwei Zhao,
Joanne M Holden,
Janet M Roseland,
Mary Brandt,
Johanna T Dwyer,
Mary Frances Picciano,
Leila G Saldanha,
Kenneth D Fisher,
Elizabeth Yetley,
Joseph M Betz,
Larry Douglass
[show abstract]
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ABSTRACT: As part of a study initiating the development of an analytically validated Dietary Supplement Ingredient Database (DSID) in the United States (US), a selection of dietary supplement products were analyzed for their caffeine content. Products sold as tablets, caplets, or capsules and listing at least one caffeine-containing ingredient (including botanicals such as guarana, yerba mate, kola nut, and green tea extract) on the label were selected for analysis based on market share information. Two or three lots of each product were purchased and analyzed using high-pressure liquid chromatography (HPLC). Each analytical run included one or two National Institute of Standards and Technology (NIST) Standard Reference Materials (SRMs) and two products in duplicate. Caffeine intake per serving and per day was calculated using the maximum recommendations on each product label. Laboratory analysis for 53 products showed product means ranging from 1 to 829 mg caffeine/day. For products with a label amount for comparison (n = 28), 89% (n = 25) of the products had analytically based caffeine levels/day of between -16% and +16% of the claimed levels. Lot-to-lot variability (n = 2 or 3) for caffeine in most products (72%) was less than 10%.
Analytical and Bioanalytical Chemistry 10/2007; 389(1):231-9. · 3.78 Impact Factor
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Amy Schweitzer
Journal of Perinatal Education 02/2006; 15(4):44-5.
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Johanna T. Dwyer,
Mary Frances Picciano,
Joseph M. Betz,
Kenneth D. Fisher,
Leila G. Saldanha,
Elizabeth A. Yetley,
Paul M. Coates,
John A. Milner,
Jackie Whitted,
Vicki Burt, [......],
Jaimie Wilger,
Katherine E. Sharpless,
Joanne M. Holden,
Karen Andrews,
Janet Roseland,
Cuiwei Zhao, Amy Schweitzer,
James Harnly,
Wayne R. Wolf,
Charles R. Perry
[show abstract]
[hide abstract]
ABSTRACT: Although an estimated 50% of adults in the United States consume dietary supplements, analytically substantiated data on their bioactive constituents are sparse. Several programs funded by the Office of Dietary Supplements (ODS) at the National Institutes of Health enhance dietary supplement database development and help to better describe the quantitative and qualitative contributions of dietary supplements to total dietary intakes. ODS, in collaboration with the United States Department of Agriculture, is developing a Dietary Supplement Ingredient Database (DSID) verified by chemical analysis. The products chosen initially for analytical verification are adult multivitamin-mineral supplements (MVMs). These products are widely used, analytical methods are available for determining key constituents, and a certified reference material is in development. Also MVMs have no standard scientific, regulatory, or marketplace definitions and have widely varying compositions, characteristics, and bioavailability. Furthermore, the extent to which actual amounts of vitamins and minerals in a product deviate from label values is not known. Ultimately, DSID will prove useful to professionals in permitting more accurate estimation of the contribution of dietary supplements to total dietary intakes of nutrients and better evaluation of the role of dietary supplements in promoting health and well-being. ODS is also collaborating with the National Center for Health Statistics to enhance the National Health and Nutrition Examination Survey dietary supplement label database. The newest ODS effort explores the feasibility and practicality of developing a database of all dietary supplement labels marketed in the US. This article describes these and supporting projects.
Journal of Food Composition and Analysis.
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Janet M. Roseland,
Joanne M. Holden,
Karen W. Andrews,
Cuiwei Zhao, Amy Schweitzer,
James Harnly,
Wayne R. Wolf,
Charles R. Perry,
Johanna T. Dwyer,
Mary Frances Picciano,
Joseph M. Betz,
Leila G. Saldanha,
Elizabeth A. Yetley,
Kenneth D. Fisher,
Katherine E. Sharpless
[show abstract]
[hide abstract]
ABSTRACT: The Nutrient Data Laboratory of the United States Department of Agriculture (USDA) is collaborating with the Office of Dietary Supplements (ODS), the National Center for Health Statistics (NCHS), and other government agencies to design and populate a dietary supplement ingredient database (DSID). This analytically based, publicly available database will provide reliable estimates of vitamin and mineral content of dietary supplement (DS) products. The DSID will initially be populated with multivitamin/mineral (MVM) products because they are the most commonly consumed supplements. Challenges associated with the analysis of MVMs were identified and investigated. A pilot study addressing the identification of appropriate analytical methods, sample preparation protocols, and experienced laboratories for the analysis of 12 vitamins and 11 minerals in adult MVM supplement products was completed. Preliminary studies support the development of additional analytical studies with results that can be applied to the DSID. Total intakes from foods and supplements are needed to evaluate the associations between dietary components and health. The DSID will provide better estimates of actual nutrient intake from supplements than databases that rely on label values alone.
Journal of Food Composition and Analysis.
