M Morsink

Publications (3)4.47 Total impact

• Article: Wel een schakeljaar in de basisopleiding geneeskunde

  W. P. J. van Oosterhout, M. Morsink
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  ABSTRACT: Binnen een aantal medische opleidingen wordt op dit moment geëxperimenteerd met het zogenaamde schakeljaar. Het schakeljaar – als laatste jaar van de basisopleiding geneeskunde – biedt mogelijkheden tot een efficiëntere aansluiting van de basisopleiding op de specialistische vervolgopleiding. Enerzijds heeft het het karakter van een studieperiode, anderzijds bereidt het voor op een medisch-specialistische vervolgopleiding. De werkervaring en de competenties die de zogenoemde semi-arts verwerft, leiden tot een soepeler overgang van coassistent naar arts en tot een mogelijke verkorting van de vervolgopleiding. Ook wanneer de opleidingsduur niet werkelijk wordt verkort, heeft het schakeljaar nut als oriëntatie-, verdiepings- en profileringsfase met een grotere kans op toelating tot een vervolgopleiding.
  05/2012; 26(4):148-149.
• Article: [A 'connecting year' is useful in the medical curriculum].

  W P J van Oosterhout, M Morsink
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  ABSTRACT: The 'schakeljaar' (connecting year) is the final year of the medical curriculum in which both education and the preparation for clinical activity as a resident are important features. Thus, a smooth transition from medical study to residency is guaranteed. However, a few criteria must be met. Firstly, sufficient knowledge, skills and clinical independence must have been accumulated during the preceding years. Secondly, intensive supervision during the connecting year is indispensable for professional and personal development. Thirdly, a connecting year spent in a certain specialty should not interfere with the choice for residency in another specialty. The students ofthe Dutch Medical Association support a rapid and nationwide introduction ofa connecting year in all eight medical faculties.
  Nederlands tijdschrift voor geneeskunde 10/2007; 151(35):1950.
• Article: Effects of urinary and recombinant gonadotrophins on gene expression profiles during the murine peri-implantation period.

  R M Sibug, N Datson, A M I Tijssen, M Morsink, J de Koning, E R de Kloet, F M Helmerhorst
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  ABSTRACT: Controlled ovarian stimulation (COS) with urinary gonadotrophins but not recombinant gonadotrophins, adversely affect the implantation process. In this study, we investigated the effects of urinary and recombinant gonadotrophins on gene expression profiles at implantation sites during the mouse peri-implantation period and the possible molecular mechanisms involved in the detrimental effects of urinary gonadotrophins using microarray technology. Adult female CD1 mice were treated with (i) urinary human FSH (hFSH) and urinary HCG, (ii) recombinant hFSH and recombinant human LH or (iii) saline. Gene expression profiling with GeneChip mouse genome 430 2.0 arrays, containing 45 101 probe sets, was performed using implantation sites on embryonic day 5. Data were statistically analysed using Significance Analysis of Microarrays. Ten genes from the microarray analysis were selected for validation using quantitative RT-PCR (qRT-PCR). A parallel group of pregnant mice was allowed to give birth to study the effect of gonadotrophins on resorption. Urinary gonadotrophins differentially up-regulated the expression of 30 genes, increased resorption and reduced litter size, whereas recombinant gonadotrophins did not. Nine of the 10 genes were confirmed by qRT-PCR. Urinary gonadotrophins, but not recombinant gonadotrophins, exerted differential effects on gene expression during the murine peri-implantation period. These findings might contribute to improve protocols for COS, leading to higher successful pregnancy rates.
  Human Reproduction 02/2007; 22(1):75-82. · 4.47 Impact Factor