Sophie Guillard

Centre Hospitalier Universitaire de Nantes, Naoned, Pays de la Loire, France

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Publications (2)2.7 Total impact

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    ABSTRACT: The aneurysmal bone cyst is a rare tumor. Its treatment is complex when localized to the lumbar spine, with neurological, mechanical, and tumoral complications. The aim of this study is to describe these tumors, their treatment, and their long-term evolution, as well as to define an appropriate therapeutic strategy. Four of the five cysts had anterior and posterior extension. Three patients had neurological symptoms at diagnosis and two of them presented with pathological fracture. Surgical treatment was performed by intralesional resection. Long-term progress was always favorable, without recurrence or functional limitation. Two patients had a stable, mild spine deformity.
    Journal of pediatric orthopaedics. Part B / European Paediatric Orthopaedic Society, Pediatric Orthopaedic Society of North America 12/2011; 21(3):269-75. DOI:10.1097/BPB.0b013e32834f16b5 · 0.66 Impact Factor
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    ABSTRACT: Enchondromas are common intraosseous usually benign cartilaginous tumors that develop in close proximity to growth plate cartilage. Genochondromatosis is a familial skeletal condition with autosomal dominant inheritance pattern. Genochondromatosis type I is a skeletal disorder characterized by symmetrical chondromatosis with characteristic localization: clavicle, upper end of humerus, and lower end of femur. The condition shows a benign course and is clearly different from metachondromatosis, generalized enchondromatosis, and spondyloenchondrodysplasia. In contrast, genochondromatosis type II is characterized by normal clavicles, but metaphyseal involvement of the hands, feet, knees, and wrists. To date, one family has been described with two affected individuals and possibly a second one with seven affected individuals. We report here on a boy with radiographic features of genochondromatosis type II. This report confirms that this disorder represents a separate clinical entity distinguishable for genochondromatosis type I. In addition, this report confirms the benign course of this rare disorder and will help accurate genetic counseling.
    American Journal of Medical Genetics Part A 08/2007; 143A(16):1919-21. DOI:10.1002/ajmg.a.31854 · 2.05 Impact Factor