Urology 11/2011; 78(5):1150. · 2.43 Impact Factor
ABSTRACT: To compare the prevalence, symptoms, and pathologic changes related to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with significant prostatitis-like symptoms between 2 altitude areas in northwest China.
From October 2009 to March 2010 community male residents at 3000 m (Delingha) and 400 m (Xi'An) constituted the population base for the present cross-sectional study. All participants completed a detailed questionnaire containing the National Institutes of Health Chronic Prostatitis Symptom Index, and the subjects who met our definition were invited to undergo clinical evaluation. After screening, the subjects considered to have CP/CPPS were separated into 2 groups: those with type IIIa and those with type IIIb CP/CPPS.
The prevalence of CP/CPPS with significant prostatitis-like symptoms was significantly different between the 2 groups. Moreover, the National Institutes of Health Chronic Prostatitis Symptom Index of patients with type IIIa and IIIb in 2 groups differed significantly, indicating the aggravation of symptoms of CP/CPPS at a high altitude. Additional investigations showed that reactive oxygen species were increased, accompanied by a decrease in the total antioxidant capacity in the expressed prostatic secretions of patients with type IIIa at a higher altitude. In addition, the tumor necrosis factor-α, interleukin-8, and interleukin-10 levels in the expressed prostatic secretions of patients with type IIIa in Delingha were increased compared with that in the patients with type IIIa in Xi'An. Notably, the interleukin-6 level in the expressed prostatic secretions was greater in those with type IIIa and IIIb at a higher altitude than in those with type IIIa and IIIb at a low altitude.
At a high altitude, the symptoms of CP/CPPS were aggravated. Oxidative stress and cytokines might involve in the pathologic process and the aggravation of symptoms. In addition, in a high altitude area the pathomechanisms of type IIIa and IIIb CP/CPPS differed.
Urology 11/2011; 78(5):1142-9. · 2.43 Impact Factor
ABSTRACT: To investigate the prevalence and characteristics of sexual dysfunction in patients with chronic prostatitis (CP) in the high altitude area.
A total of 637 CP patients randomly recruited from different urologic clinics were divided into 4 groups according to their living altitudes. The subjects were scored on the National Institute of the Health Chronic Prostatitis Symptom Index (NIH-CPSI), the International Index of Erectile Function-5 (IIEF-5), the Chinese Index of Sexual Function for Premature Ejaculation (C-ISFPE) and the questionnaire on ejaculatory difficulties from the University of Washington Symptom Score.
In the 637 CP patients, the overall incidences of premature ejaculation (PE), erectile dysfunction (ED) and difficult ejaculation (DE) were 28.4%, 17.6% and 23.9%, respectively, 9.9% with PE, ED and DE simultaneously. With the increase of the living altitude, the scores on IIEF-5 (P = 0.032) and C-ISFPE (P = 0. 047) were obviously decreased, and the incidences of PE (P = 0.047), ED (P = 0.046) and DE (P = 0.019) markedly elevated. Those with PE or ED experienced worse symptoms at a higher altitude (r = 0.249 or 0.267, P < 0.05). The differences were all statistically significant.
The prevalence and severity of sexual dysfunction are positively correlated with the living altitude among CP patients.
Zhonghua nan ke xue = National journal of andrology 10/2009; 15(10):886-90.
ABSTRACT: To detect the VHL gene mutations in a Chinese family with nonsyndromic pheochromocytoma.
Mutations of VHL gene were detected in a Chinese family with nonsyndromic pheochromocytoma. Five patients and fifteen relatives were involved in this study. Peripheral blood was collected and total genomic DNA was prepared for polymerase chain reaction (PCR). PCR products of all the three exons of VHL gene were purified and a direct gene sequence analysis was performed.
All the five patients presented a codon 125 from Histidine (H) to Proline (P) change at nucleotide 587 (A --> C) in exon 2. Seven members of fifteen relatives were carriers with the same VHL gene mutation. Two carriers were detected with bilateral adrenal tumors and right renal cyst respectively by ultrasonic inspection.
The novel VHL gene mutation detected in this kindred may be the causative gene. Genetic test can detect the carriers in an early period. It is recommended as a routine method of genetic test in nonsyndromic pheochromocytoma patients.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 08/2007; 24(4):365-8.