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ABSTRACT: To determine the effect of MEK inhibitor (U0126) on donor testes from ischemia-reperfusion injury after orthotopic testicular transplantation in rats.
The rats were divided into 7 groups, Group 1: normal control; Group 2: cold perfusion control; Group 3: sham operation control; Group 4: transplanted for 30 min; Group 5: transplanted for 1 week; Group 6: transplanted for 30 min with pretreatment of U0126; Group 7: transplanted for 1 week with pretreatment of U0126. The orthotopic testicular transplantation model was established with cuff. The levels of ERK1, ERK2, pERK1 and pERK2 of donor testes were evaluated; the change of histology and gonadal hormones were measured as well.
Group 1, 2 and 3 had no significant differences in all results (P>0.05). The levels of ERK1, ERK2, pERK1 and pERK2 in Group 4 were significantly increased compared with Group 1 (P<0.05), the levels of ERK1 and ERK2 in Group 6 were not different from those of Group 4 (P >0.05), but the levels of pERK1 and pERK2 in Group 6 were lower than those in Group 4 significantly(P <0.05), the histological changes in Group 6 were similar to Group 1 but milder than that in Group 4. The histological injury was more severe in Group 5 than that in Group 7, and the levels of gonadal hormones in Group 5 were lower than those in Group 7 (P <0.05) which remained at the normal levels.
U0126 has a protective effect on the donor testes in a short period through inhibiting expression of pERK1/2 activated by testicular transplantation.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 01/2009; 38(1):81-8.
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ABSTRACT: To investigate the rates of prostate cancer (PCa) in radical cystoprostatectomy (RCP) specimens for bladder cancer in mainland China. To determine the follow-up outcome of patients with two concurrent cancers and identify whether prostate-specific antigen (PSA) is a useful tool for the detection of PCa prior to surgery.
From January 2002 to January 2007, 264 male patients with bladder cancer underwent RCP at our center. All patients underwent digital rectal examination (DRE) and B ultrasound. Serum PSA levels were tested in 168 patients. None of the patients had any evidence of PCa before RCP. Entire prostates were embedded and sectioned at 5 mm intervals.
Incidental PCa was observed in 37 of 264 (14.0%) RCP specimens. Of these, 12 (32.4%) were clinically significant according to an accepted definition. The PSA levels were not significantly different between patients with PCa and those without PCa, nor between patients with significant PCa and those with insignificant PCa. Thirty-four patients with incidental PCa were followed up. During a mean follow-up period of 26 months, two patients with PSA > 4 ng/mL underwent castration. None of the patients died of PCa.
The incidence of PCa in RCP specimens in mainland China is lower than that in most developed countries. PSA cannot identify asymptomatic PCa prior to RCP. In line with published reports, incidental PCa does not impact the prognosis of bladder cancer patients undergoing RCP.
Asian Journal of Andrology 09/2008; 10(5):809-14. · 1.52 Impact Factor
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ABSTRACT: An investigation from 2006 to 2007 was made on the Pinus koraiensis seed consumption by rodents and birds in the broad-leaved P. koraiensis mixed forest and birch forest at the same altitude in Changbai Mountains. The results showed that in broad-leaved P. koraiensis mixed forest, rodents consumed more pinecone seeds than birds; while in birch forest, birds did more than rodents. In the two forests, the total number of pinecone seeds consumed by rodents was significantly higher than that consumed by birds (P < 0.01). In addition, rodents consumed more embedded seeds in broad-leaved P. koraiensis mixed forest than in birch forest, and the consumption amount in the two forests decreased with increasing embedded depth.
Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban 08/2008; 19(8):1759-63.
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ABSTRACT: In this paper, the species composition, seasonal dynamics, and spatial distribution patterns of herbs were examined in a 25 hm2 broadleaved Korean pine (Pinus koraiensis) mixed forest plot in Changbai Mountains. The results showed that the plot had a relatively high herbaceous richness, with 102 species belonging to 40 families and 84 genera, and the Shannon index, Simpson index, and Pielou index was 3.52, 0.96 and 0.75, respectively. The three indices varied dramatically with growth season, whereas the species abundance decreased linearly from early spring to autumn. The species richness and abundance showed irregular distribution, indicating that herbaceous species were microenvironment-dependent. Slope aspect had significant effects on herbaceous species richness and abundance. Northern and eastern slopes had higher species richness and abundance in early spring than southern and western slopes, whereas it was in adverse in late summer and autumn.
Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban 04/2008; 19(3):467-73.
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ABSTRACT: Based on the investigation data from a 25 hm2 broadleaved Korean pine (Pinus koraiensis) mixed forest plot in Changbai Mountains of China, the dominant species Korean pine and Tilia amurensis were chosen as research objects. One point pattern analysis method, O-ring statistics, was used to analyze the spatial patterns of the species in three vertical layers, i. e., overstory, midstory and understory layers, and the spatial associations of intra- and inter-species between different vertical layers were studied. The results showed that P. koraiensis and T. amurensis were clumped at smaller scales. Higher layers tended to be randomly or regularly distributed, while lower layers tended to be aggregated at smaller scales. The aggregation degree decreased with canopy height. P. koraiensis stems in overstory layer were significantly positively associated to the stems in midstory layer at scales < 11 m, and T. amurensis in overstory layer showed negatively correlation with that in midstory and understory layers. There was generally a positive correlation between the two species, but the association varied among different layers. No significant correlation was observed between P. koraiensis stems in overstory layer and T. amurensis in three layers. P. koraiensis stems in midstory layer showed slightly negative correlation with T. amurensis in the same layer at scales > 4 m, but no significant association to T. amurensis in understroy layer. T. amurensis in overstory layer was significantly positively associated to P. koraiensis in midstory layer at scales < 100 m.
Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban 08/2007; 18(8):1681-7.
