Publications (2)4.96 Total impact
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Article: Contrast-enhanced ultrasound-guided microwave tissue coagulation therapy for hepatic trauma: an experimental study.
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ABSTRACT: Nonoperative therapies for hepatic trauma have become more popular. Because there is a potential application of microwave tissue coagulation (MTC) in the minimally invasive management of hepatic trauma, this study aimed to evaluate the efficacy of contrast-enhanced ultrasound (CEUS)- guided MTC therapy for hepatic trauma. Forty hepatic lacerations were created intraoperatively in 10 heparinized porcine livers. MTC therapy was performed under CEUS guidance. Two hours after MTC, CEUS and histopathologic examination were performed to assess the effect of MTC therapy. All hepatic lacerations with active bleeding were successfully controlled with MTC therapy. The bleeding times in grade II and III lacerations (192.0 +/- 108.0 seconds, 443.4 +/- 63.5 seconds, respectively) were longer than that in grade I (48.3 +/- 33.3 seconds; p < 0.01), and blood losses (24.8 +/- 6.5 g, 47.8 +/- 10.5 g) were also higher than in grade I (6.6 +/- 4.3 g; p < 0.01). All grade I lacerations (16 of 16, 100%), 7 grade II (7 of 16, 43.8%), and 3 grade III (3 of 8, 37.5%) were not enhanced on CEUS except for the electrode track appearing as a hyperechoic strip. In 9 grade II lacerations and 8 grade III lacerations, most of treated region was unenhanced apart from a few small regular vascular enhancements at the periphery of treated region. Histopathologic examination showed that there was no hematoma in any microwave-treated region and the hepatocytes in treated region were obviously necrotic. MTC therapy is a simple and effective method and may have great potential in minimally invasive treatment of hepatic trauma.The Journal of trauma 05/2008; 64(4):1079-84. · 2.48 Impact Factor -
Article: The value of contrast-enhanced gray-scale ultrasound in the diagnosis of hepatic trauma: an animal experiment.
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ABSTRACT: Conventional ultrasonography (US) shows markedly lower sensitivity in detecting parenchymal injury and active bleeding in abdominal organs. This study was designed to evaluate the utility of contrast-enhanced US (CEUS) in the diagnosis of blunt trauma and active hemorrhage of the liver in an animal model. Sixteen blunt injuries and 40 lacerations with active hemorrhage were created in livers of 14 pigs using laparotomy. The lacerations were divided into two groups: group I, in which the velocity of the traumatized artery was >20 cm/s; and group II, in which the velocity of the traumatized artery was < or =20 cm/s. Twenty minutes after the blunt trauma and immediately after the laceration was created, conventional US and CEUS were performed to observe the sonographic characteristics of trauma. The sensitivity of CEUS in detecting blunt hepatic trauma (100%; 16 of 16) was significantly higher than that of conventional US (37.5%; 6 of 16) (p < 0.001) based on the histopathology gold standard. Active hemorrhage was clearly detected as hyperechoic enhanced linear or clumpy regions in all of the lacerations in group I (100%; 20 of 20) and in 65% (13 of 20) of the lacerations in group II on CEUS. Acoustic shadowing was observed posterior to the enhanced hemorrhagic site in 12 lacerations from group I and in five lacerations from group II. In this animal model, CEUS was found to be useful in detecting blunt trauma and active hemorrhage in the liver, which might significantly improve the efficacy of US for the diagnosis of hepatic trauma.The Journal of trauma 06/2007; 62(6):1468-72. · 2.48 Impact Factor
