Isabel de Camargo Costa

Publications (2)3.06 Total impact

• Article: Evaluation of humoral response to heptavalent pneumococcal conjugate vaccine in HIV-infected children.

  Isabel de Camargo Costa, Fabiana Guilardi, Mariana Acenjo Kmiliauskis, Christina Arslanian, Evandro Roberto Baldacci
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  ABSTRACT: Invasive pneumococcal disease is a major cause of death in HIV-infected children. The objective of the study was to assess the quantitative antibody response to the seven pneumococcal serotypes of heptavalent pneumococcal conjugate vaccine in a group of HIV-infected children. Study comprising 40 HIV-infected children aged between 2 and 9 years followed up in a specialized outpatient clinic in São Paulo, Brazil, between 2002 and 2003. Enzyme immunoassay (ELISA) was used to measure IgG antibody titers against pneumococcus capsule. Antibodies were measured immediately before and 1 month after the second dose of the vaccine. Two response criteria were used: IgG titers >or=1.3 microg/mL in the post-immunization serology and an increase of at least 4or=-fold in post- compared to pre-immunization serology. For the first criterion (>or=1.3 microg/mL), 26 (65%) children had serological response to the vaccine, 12 (30%) showed post-immunization IgG titers of at least 1.3 microg/mL for all seven serotypes studied. For the second criterion studied (>or=4-fold increase in post- compared to pre-immunization titers for four serotypes or more), serological response was seen in 15 (37.5%) children. Overall response to the heptavalent pneumococcal conjugate vaccine was adequate, showing a statistically significant increase in the post-immunization geometric mean titers for the seven serotypes studied.
  Revista de saude publica 09/2008; 42(5):844-50. · 1.01 Impact Factor
• Article: Reliability of information on varicella history in preschool children.

  Lúcia Ferro Bricks, Cláudio Sérgio Pannuti, Helena Keico Sato, Eneida S Ramos Vico, Adriana Melo de Faria, Vanda V A U Souza, Laura M Sumita, Isabel de Camargo Costa, Evandro Roberto Baldacci
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  ABSTRACT: To verify how reliable is the information provided by parents about the history of varicella in their children. 204 parents of previously healthy children attending two municipal day-care centers of São Paulo city were interviewed between August 2003 and September 2005. A standardized form was filled out with information regarding age, sex, history of varicella and other diseases, drug use and antecedent of immunization, After medical history, physical examination and checking of immunization records, 5 ml of blood were collected for ELISA (in house) varicella test. Exclusion criteria were: age less than 1 year or more than 60 months, previous immunization against chickenpox, presence of co-morbidities or recent use of immunosuppressive drugs. Data were filed in a data bank using the Excel 2003 Microsoft Office Program and stored in a PC computer. The exact Fisher test was employed to calculate sensibility, specificity, positive and negative predictive values of history of varicella informed by children's parents. The age of the children varied from 12 to 54 months (median, 26 months; 49 (24%) children had positive history of varicella, 155 (76%) a negative or doubtful history. The predictive positive and negative values of the information were 90% and 93%, respectively (p = 0.0001). The degree of reliability of information about history of varicella informed by parents of children attending day care centers was high and useful to establish recommendations on varicella blocking immunization in day-care centers.
  Clinics 07/2007; 62(3):309-14. · 2.06 Impact Factor