Sulian Zheng

Publications (2)5.67 Total impact

• Article: Metal ion mediated synthesis of molecularly imprinted polymers targeting tetracyclines in aqueous samples.

  Guorun Qu, Sulian Zheng, Yumin Liu, Wei Xie, Aibo Wu, Dabing Zhang
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  ABSTRACT: Molecularly imprinted polymers (MIPs) prepared in water-containing systems are more appropriate as adsorption materials in analyte extraction from biological samples. However, water as a polar solvent involved in the synthesis of MIPs frequently disrupts non-covalent interactions, and causes non-specific binding. In this study Fe(2+) was used as mediator to prepare MIPs, targeting tetracyclines (TCs) of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC), with TC as template molecule and methacrylic acid (MAA) as functional monomer. The subsequent binding assay indicated that Fe(2+) was responsible for substantially improved specific binding in recognition of TCs by decreasing the non-specific binding. Spectrophotometric analysis suggested the existence of the strong interactions among TC, metal ions and MAA in the mixture of methanol and water. Moreover, mass spectrometric measurements verified that Fe(2+) could bridge between TC and MAA to form a ternary complex of one TC, one Fe(2+) and four MAAs with a mass of 844.857. Furthermore, combined with molecularly imprinted solid-phase extraction (MISPE) for sample pretreatment, HPLC-UV analysis data revealed good performance of the obtained MIPs as adsorbents. The recoveries of TC, OTC and CTC in urine samples were 80.1-91.6%, 78.4-89.3% and 78.2-86.2%, respectively. This research strategy provides an example for preparation of desirable water-compatible MIPs extracting target drugs from aqueous samples by introducing metal ion as mediator into conventional polymerization system.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 09/2009; 877(27):3187-93. · 2.78 Impact Factor
• Article: Newly Combined Method of Molecularly Imprinted SolidPhase Extraction with ELISA for Rapid Detection of Clenbuterol in Animal-Tissue Samples

  Sulian Zheng, Suquan Song, Huo Lan, Guorun Qu, Rongxiu Li, Aibo Wu, Dabing Zhang
  Analytical Letters - ANAL LETT. 01/2009; 42(3):600-614.
• Article: Molecularly imprinted polymer microspheres for solid-phase extraction of chloramphenicol residues in foods.

  Xizhi Shi, Aibo Wu, Sulian Zheng, Rongxiu Li, Dabing Zhang
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  ABSTRACT: Preparation of molecularly imprinted polymer microspheres (MIPMs) for chloramphenicol (CAP) by aqueous suspension polymerization is reported for the first time in this study. The resulting MIPMs had the ability to specifically adsorb CAP, and the molecularly imprinted solid phase extraction (MISPE) based on the MIPMs was shown to be applicable for clean-up and preconcentration of trace CAP in milk and shrimp samples with high recoveries of 92.7% and 84.9%, respectively. Combined with MISPE, the conventional HPLC-UV analysis sensitivity for CAP in foods could be significantly increased.
  Journal of Chromatography B 06/2007; 850(1-2):24-30. · 2.89 Impact Factor