Juan C Rodríguez-Borregán

Publications (3)4.84 Total impact

• Article: A severe case of olanzapine overdose with analytical data.

  Salomé Ballesteros, María A Martínez, M Angeles Ballesteros, Carolina Sánchez de la Torre, Juan C Rodríguez-Borregán
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  ABSTRACT: Olanzapine is a second-generation atypical antipsychotic agent approved for the treatment of psychotic disorders and mania. While olanzapine overdoses are common, cases with whole blood concentrations are less so. We describe here a well-documented case of a pure olanzapine overdose in which whole blood concentrations were determined, and compared with other concentrations in the literature. A 58-year-old woman with a 10-year history of paranoid schizophrenia and poor therapeutic compliance was found unconscious with two empty 28-tablet vials of Zyprexa (olanzapine) 10 mg tablets. Her initial vital signs were blood pressure 110/70 mmHg, pulse rate 82 beats/minute (sinus rhythm), respirations 20 breaths/minute, and the Glasgow Coma Scale score was 7. In the Intensive Care Unit, her pulse rate was 160 beats/minute, in sinus rhythm, and QTc 0.423 seconds (normal <0.4 seconds). Relevant analytical findings were metabolic acidosis, leukocytosis, creatine phosphokinase 1992 mg/dL, and glucose 207 mg/dL. Ten hours after being found, her blood sugar was 350 mg/dL and became normal at 25 hours. The patient needed intubation and insulin. Olanzapine was detected and quantitated by gas chromatography with nitrogen-phosphorus detector and confirmed by gas chromatography-mass spectrometry using a validated analytical method. At approximately 4, 8, and 12 hours post-ingestion, whole blood concentrations of olanzapine were 0.41, 0.34, and 0.38 mg/L, respectively. This study reports an acute olanzapine monointoxication with severe toxicity and high whole blood olanzapine concentrations. Clinical and analytical data of similar samples obtained in non-fatal life-threatening cases can be very useful when interpreting postmortem cases.
  Clinical Toxicology 05/2007; 45(4):412-5. · 2.22 Impact Factor
• Article: Cardiac contusion following blunt chest trauma.

  María S Holanda, María J Domínguez, Francisco López-Espadas, Marta López, Jenaro Díaz-Regañón, Juan C Rodríguez-Borregán
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  ABSTRACT: Cardiac contusion following blunt chest trauma is not rare, and the works in the literature report incidence rates between 5 and 50%. Traffic accidents are the most frequent cause of cardiac contusion followed by violent fall impacts, aggressions and the practice of risky sports. The spectrum of post-traumatic cardiac lesions varies greatly, ranging from no symptoms to decrease in cardiac function. Cardiogenic shock is a rarely encountered manifestation of blunt cardiac contusion. We review our experience of cardiac contusion after blunt chest trauma, and we describe two very severe cases that manifested as cardiogenic shock. We emphasize an early diagnosis by continuous electrocardiographic monitoring, serial electrocardiograms, echocardiography, serum determination of biochemical cardiac markers, radionuclide imaging and coronary angiography. The treatment includes continuous monitoring of cardiac rhythm, use of inotropic drugs, insertion of a catheter in the pulmonary artery for continuous assessment of cardiac output and, in extreme cases, the insertion of a contrapulsation balloon to maintain haemodynamics until improvement of cardiac function.
  European Journal of Emergency Medicine 01/2007; 13(6):373-6. · 0.90 Impact Factor
• Article: Pneumonia due to Mycoplasma hominis in a healthy adult.

  Ana Sáez, Idoia Monteagudo, Eduardo Miñambres, Elsa Ots, Juan C Rodríguez-Borregán, Celia García
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  ABSTRACT: A case of pneumonia due to Mycoplasma hominis in a healthy adult is presented. The bacterium was diagnosed by a quantitative culture method and identification to the species level by sequence analysis of 16S rRNA gene. The objective of this presentation is to bring to attention the need to search for this opportunistic pathogen. Mycoplasma may be an important cause of bacterial pneumonia without microbiological diagnosis and its incidence may be underestimated.
  Scandinavian Journal of Infectious Diseases 02/2003; 35(4):282-4. · 1.72 Impact Factor