Ting Shen

Publications (6)11.39 Total impact

• Article: Giant cell fibroblastoma of the vulva at the site of a previous fibroepithelial stromal polyp: a case report.

  Xin Han, Ting Shen, Luis A Rojas-Espaillat, Enrique Hernandez
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  ABSTRACT: Giant cell fibroblastoma (GCF) is an unusual soft tissue tumor, occurring predominantly in infants and children, and rarely in adults. Giant cell fibroblastoma develops de novo in the dermis or subcutis with a predilection for the extremities, the abdominal and chest walls, umbilical and inguinal regions. A GCF arose at the same site (labium majus of vulva) as a previous cellular fibroepithelial stromal polyp in a 28-year-old woman. We report a case of GCF of the vulva, an unreported site.
  Journal of Lower Genital Tract Disease 05/2007; 11(2):112-7. · 1.07 Impact Factor
• Article: Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions.

  Jasvir S Khurana, Shuji Ogino, Ting Shen, Hemant Parekh, Uwe Scherbel, William DeLong, Michael D Feldman, Paul J Zhang, Hubert J Wolfe, Benjamin A Alman
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  ABSTRACT: Bone morphogenetic proteins (BMPs) are thought to be responsible for bone formation; they cause bone to form in soft tissues and are clinically used in helping fracture union or tumor reconstructions. Skeletal metastases from epithelial tumors may be either bone-forming (blastic) or non-bone-forming (lytic). We studied the expression of BMPs in a variety of primary and secondary lesions of bone (both bone-forming and non-bone-forming) to determine if there was a consistent relationship between bone formation and BMP expression. We compared a bone-forming lesion (fibrous dysplasia) with a non-bone-forming lesion (desmoid tumor), using reverse transcription-polymerase chain reaction, Northern blot analysis, and immunohistochemistry to detect BMPs. We also studied a number of non-bone-forming secondary lesions (carcinomas that formed lytic metastases to the skeleton) and found BMP production in most of these tumors. We found that BMPs were expressed in both bone-forming and non-bone-forming benign musculoskeletal lesions. In the first part of the study, BMPs were found in both fibrous dysplasia and desmoid tumors. Bone morphogenetic proteins were also expressed by several tumors. In the next part of the study (paraffin-embedded tissue), BMPs were expressed by a variety of tumors, irrespective of the radiological nature (blastic or lytic) of their metastases. We conclude that BMP production alone cannot explain bone formation, and other factors either alone or in combination may be responsible for blastic metastases to the skeleton and for bone formation by primary bone lesions, such as fibrous dysplasia.
  Archives of pathology & laboratory medicine 12/2004; 128(11):1267-69. · 2.58 Impact Factor
• Article: Premalignant lesions in the contralateral ovary of women with unilateral ovarian carcinoma.

  Tajinder B Kaur, Ting Shen, John Gaughan, James Thompson, Karen L Houck, Michael Richardson, Enrique Hernandez
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  ABSTRACT: A limited number of studies have looked at premalignant lesions of ovaries and the results are conflicting. Our goal is to identify, histologically and by immunohistochemistry, any features that may represent premalignant changes in the ovaries. Our cases included 29 patients with unilateral ovarian cancer. These were compared to 19 controls that had unilateral benign ovarian pathology and to 39 controls with bilateral normal ovaries. Tissue sections from the contralateral normal ovary were examined. Analysis of histological features and immunohistochemical staining for the apoptosis inhibitor Bcl-2, the proliferation marker Ki-67 and the tumor suppressor gene p53 was performed. Epithelial stratification, nuclear atypia, and inclusion cysts were more often seen in the cases than in the two control groups. Epithelial stratification and nuclear atypia was statistically significantly more common among the cases than the normal controls. Inclusion cysts were present in more of the cases (P = 0.017) and in higher numbers than in the normal controls. Bcl-2 overexpression was statistically more commonly seen in the cases with contralateral ovarian cancer (39%) than in the normal controls (15%), while it was present in 28% of cases with contralateral benign pathology. Epithelial alterations and Bcl-2 overexpression was seen in all three groups studied. However, the epithelial alterations and Bcl-2 overexpression was more commonly seen in the contralateral ovary of women with unilateral ovarian cancer. This suggests an association between these changes and ovarian cancer. Although it is tempting to label the above changes premalignant, women with the above changes are at possibly higher risk of developing ovarian cancer rather than having acquired an oncogenic change that would inevitably lead to ovarian cancer.
  Gynecologic Oncology 05/2004; 93(1):69-77. · 3.89 Impact Factor
• Article: A case of adenomyosis per se with a uterine weight of 475 g.

  Ozgur H Harmanli, Ting Shen, Shaobo Zhu, Ashwin J Chatwani
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  ABSTRACT: Adenomyosis alone usually does not cause significant uterine enlargement. A 49-year-old woman underwent vaginal hysterectomy and pelvic reconstructive surgery for pelvic organ prolapse. Incidentally, she was found to have adenomyosis with a 475-gram uterus without any other uterine histopathologic finding. To our knowledge, this is the largest uterus with adenomyosis alone ever reported. Extreme enlargement of the uterus is possible due to adenomyosis alone.
  Gynecologic and Obstetric Investigation 02/2004; 58(4):216-8. · 1.28 Impact Factor
• Article: Fine-needle aspiration cytology of intra-abdominal wall extraskeletal myxoid chondrosarcoma: a case report and review of the literature.

  Farah Gaudier, Jasvir S Khurana, Sanjiv Dewan, Ting Shen
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  ABSTRACT: Extraskeletal myxoid chondrosarcoma is a rare soft tissue tumor. Most of the reported cases that were diagnosed by fine-needle aspiration were taken from the extremities, where the tumor is often found. Problems can occur when the site is unusual and cellular differentiation is not distinct. We present a case in which the tumor was located in the intra-abdominal wall, an unusual location. Cytologic features and immunocytochemistry are helpful in distinguishing this tumor from others that share similar myxoid background.
  Archives of pathology & laboratory medicine 10/2003; 127(9):1211-3. · 2.58 Impact Factor
• Article: Loop Electroexcision Procedure with the Fischer Excisor Versus the Utah Loop in a Residency Training Program

  Andrew P. Rosen, Enrique Hernandez, Ting Shen, John P. Gaughan
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  ABSTRACT: Objective: To compare the histopathologic quality of surgical specimens produced by two electrosurgical excision instruments when used by obstetrics and gynecology residents under supervision. Methods: A prospective study design was approved by the institutional review board of Temple University Health Science Campus, Philadelphia, PA. All patients who required a Loop Electroexcision Procedure (LEEP) were eligible for the study. A total of 45 patients were enrolled from December 1999 to December 2000. Twenty-two were randomized to the Fischer Excisor and 23 to the Utah Loop. The surgical procedure was performed in a routine fashion by either a fourth-year or second-year gynecology resident under the supervision of a gynecologic oncologist. The specimens were initially evaluated by Temple University Hospital Pathology Department and a histopathologic diagnosis was rendered. Each specimen was evaluated by one of the investigators masked as to which type of instrument was used. The specimens were analyzed for fragmentation, margin quality, epithelial thermal artifact, and depth of thermal damage from the excision margin. A thermal damage score was assigned to each specimen based on the microscopic depth in microns (μm) of thermal damage from the excision margin and also on the degree of epithelial thermal artifact. The overall histologic quality of the squamous epithelium margins was assessed using the resulting sum of the specimen's scores for epithelial thermal artifact and depth of damage. Lastly, after each electrosurgical procedure, the gynecology resident that performed the procedure completed a survey to critique the control, maneuverability, and comfort OF the instrument used. Results: The specimens obtained using the Fischer Excisor had significantly less thermal damage from the margins than the Utah Loop specimens. The mean thermal damage distance with the Fischer instrument was 481.94 μm (± 246.29) versus 789.76 μm (± 713.45) with the Utah Loop (P = 0.0035). The Fischer Excisor produced a median of one tissue fragment per case whereas the Utah Loop produced a median of two (P = 0.4213). The median number of passes needed to complete the procedure with the Fischer Excisor was one, whereas it was twowith the Utah Loop (mean 1.0 vs. 1.74, P = 0.00038). The overall histologic quality score was better for the specimens obtained with the Fischer Excisor than for those obtained with the Utah Loop. The Fischer Excisor displayed statistically significant better evaluations by the residents for its comfort of use, control, and maneuverability than the Utah Loop. The residents had performed an average of seven LEEPs with the Utah Loop and three with the Fischer before the study case (P = 0.0272). Conclusion: In a training program, the Fischer Excisor requires less practice to master and provides specimens with less thermal damage than the Utah Loop.
  Journal of Pelvic Medicine and Surgery 10/2001; 7(6):330-334.